Learning-related synaptic plasticity: LTP and LTD
Abstract
The past several years have seen studies of synaptic plasticity in both invertebrate and vertebrate nervous systems come of age and lead to important new findings. In particular, current evidence points to a possible presynaptic site for long-term potentiation and the involvement of a retrograde messenger from the postsynaptic neuron. Recent advances in both cerebellar and cortical forms of long-term depression are also discussed.
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Synaptic plasticity during aversive learning, such as fear conditioning in the hippocampus and amygdala, is thought to be controlled by LTP.
“Synaptic plasticity during aversive learning e.g. in fear conditioning in the hippocampus and the amygdala is thought to be controlled by LTP (Ehrlich et al., 2009;Siegelbaum and Kandel, 1991).”
From Serotonin and neuroplasticity – Links between molecular, functional and structural pathophysiology in depression (2017) · cites this paper as Siegelbaum and Kandel, 1991
Cites
Edwards, F. A., Konnerth, A., & Sakmann, B. (1990) · The Journal of Physiology · doi:10.1113/jphysiol.1990.sp018289 · Cited by 535 · see citing works
Noradrenergic enhancement of long-term potentiation at mossy fiber synapses in the hippocampus
Hopkins, W. F., & Johnston, D. (1988) · Journal of Neurophysiology · doi:10.1152/jn.1988.59.2.667 · Cited by 310 · see citing works
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Bi, G.-Q., & Poo, M.-M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-24-10464.1998 · Cited by 4,744 · see citing works
Spike Timing–Dependent Plasticity: A Hebbian Learning Rule
Caporale, N., & Dan, Y. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125639 · Cited by 1,997 · see citing works
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070 · see citing works
Kraus, C., Castrén, E., Kasper, S., & Lanzenberger, R. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.03.007 · Cited by 457 · see citing works
Functional network reorganization during learning in a brain-computer interface paradigm
Jarosiewicz, B., Chase, S. M., Fraser, G. W., Velliste, M., Kass, R. E., & Schwartz, A. B. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808113105 · Cited by 302 · see citing works
Cavanaugh, J. E., Ham, J., Hetman, M., Poser, S., Yan, C., & Xia, Z. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00434.2001 · Cited by 196 · see citing works
Type I Adenylyl Cyclase Mutant Mice Have Impaired Mossy Fiber Long-Term Potentiation
Villacres, E. C., Wong, S. T., Chavkin, C., & Storm, D. R. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03186.1998 · Cited by 187 · see citing works
“…mossy fiber LTP; cAMP; Ca21; neuroplasticity; hippocampus Long-term potentiation (LTP) in the hippocampus is a form of synaptic plasticity that may be an appropriate electrophysiological model for learning and memory (for review, see Siegelbaum and Kandel, 1991; Thompson, 1992; Malenka, 1994).”
BackgroundProcedural Learning and the Development and Stability of Character
Grigsby, J., & Hartlaub, G. H. (1994) · Perceptual and Motor Skills · doi:10.2466/pms.1994.79.1.355 · Cited by 38 · see citing works
- Authors
- Siegelbaum, S. A., & Kandel, E. R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 1991-06
- Volume
- 1
- Issue
- 1
- Pages
- 113-120
- ISSN
- 0959-4388 (ISSN-L)
- OpenAlex
- W2071406073
- Cited by
- 168
- References
- 2
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 7 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 8 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 9 · 2013: 10 · 2012: 5
- FWCI
- 1.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic plasticity, long-term potentiation, long-term depression, presynaptic plasticity, retrograde signaling, cerebellar long-term depression, learning
- MeSH terms
- Animals, Humans, Learning, Neural Pathways, Neuronal Plasticity, Synapses
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