DNA damage and the DNA-activated protein kinase
Abstract
DNA-activated protein kinase (DNA-PK) is a nuclear serine/threonine protein kinase that is activated in vitro by DNA fragments. The cellular targets of DNA-PK are nuclear, DNA-binding, regulatory proteins including Sp1, Fos, Jun, Myc, the tumor suppressor protein p53, and RNA polymerase II. These characteristics suggest a role for DNA-PK in coordinating nuclear processes and as a modulator of checkpoint mechanisms activated by DNA damage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
That study concluded increased TMAO excretion could be due to tubulointerstitial distortions.
“The study concluded that this increased excretion of TMAO could be due to tubulointerstitial distortions (4).”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [4]
An NMR-based metabolomics study found urinary TMAO associated with tubulointerstitial lesions in 77 glomerulonephritis patients.
“An NMR-based metabolomics study observed an association between urinary TMAO concentrations and tubulointerstitial lesions in patients (n = 77) with glomerulonephritis.”
From Trimethylamine <i>N</i> -Oxide, the Microbiome, and Heart and Kidney Disease (2017) · cites this paper as [4]
The citation lists haven’t been fetched yet
References 26 · Cited by 235
- Authors
- Anderson, C. W.
- Affiliations
- Brookhaven National Laboratory (US)
- Corresponding author
- Anderson, Carl W.
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1993-11
- Volume
- 18
- Issue
- 11
- Pages
- 433-437
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2029280671
- Cited by
- 235
- References
- 26
- Citations by year
- 2023: 3 · 2022: 2 · 2021: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 5 · 2012: 2
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Department of Energy
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Keywords
- DNA-dependent protein kinase, DNA damage, DNA damage response, p53, Sp1, FOS, c-Jun, c-Myc, RNA polymerase II, serine/threonine kinase, nuclear proteins
- MeSH terms
- Amino Acid Sequence, Animals, DNA Damage, DNA-Binding Proteins, Humans, Molecular Sequence Data, Nuclear Proteins, Peptides, Phosphorylation, Substrate Specificity, Protein Serine-Threonine Kinases, DNA-Activated Protein Kinase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
