The WW domain: a signalling site in dystrophin?
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WW domains bind to proteins containing a minimal consensus sequence of XPPXY.
“WW domains are small modules of 35 to 40 amino acids that are characterized by four well conserved aromatic residues of which two are tryptophans, that bind to proteins containing a minimal consensus sequence of XPPXY (Bork and Sudol, 1994; Chen and Sudol, 1995).”
From LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) · cites this paper as Bork and Sudol, 1994
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Sudol, M., Bork, P., Einbond, A., Kastury, K., Druck, T., Negrini, M., Huebner, K., & Lehman, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.24.14733 · Cited by 342 · see citing works
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Jasenosky, L. D., Neumann, G., Lukashevich, I., & Kawaoka, Y. (2001) · Journal of Virology · doi:10.1128/jvi.75.11.5205-5214.2001 · Cited by 286 · see citing works
Demirov, D. G., Orenstein, J. M., & Freed, E. O. (2002) · Journal of Virology · doi:10.1128/jvi.76.1.105-117.2002 · Cited by 201 · see citing works
Modularity in the Hippo signaling pathway
Sudol, M., & Harvey, K. F. (2010) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.05.010 · Cited by 149 · see citing works
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Wackerhage, H., Del Re, D. P., Judson, R. N., Sudol, M., & Sadoshima, J. (2014) · Science Signaling · doi:10.1126/scisignal.2005096 · Cited by 92 · see citing works
Self-citationLabel-free quantitative proteomic analysis of the YAP/TAZ interactome
Kohli, P., Bartram, M. P., Habbig, S., Pahmeyer, C., Lamkemeyer, T., Benzing, T., Schermer, B., & Rinschen, M. M. (2014) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00339.2013 · Cited by 61 · see citing works
Ranganathan, S., Noyes, N. C., Migliorini, M., Winkles, J. A., Battey, F. D., Hyman, B. T., Smith, E., Yepes, M., Mikhailenko, I., & Strickland, D. K. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5065-10.2011 · Cited by 49 · see citing works
“WW domains are small modules of 35 to 40 amino acids that are characterized by four well conserved aromatic residues of which two are tryptophans, that bind to proteins containing a minimal consensus sequence of XPPXY (Bork and Sudol, 1994; Chen and Sudol, 1995).”
Background
- Authors
- Bork, P., & Sudol, M.
- Affiliations
- Rockefeller University (US)
- ORCID
- Sudol, Marius
- Venue
- Trends in Biochemical Sciences
- Publisher
- Elsevier BV
- Published
- 1994-12
- Volume
- 19
- Issue
- 12
- Pages
- 531-533
- ISSN
- 0968-0004 (ISSN-L)
- OpenAlex
- W2049480511
- Cited by
- 388
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 1 · 2023: 5 · 2022: 5 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 11 · 2016: 7 · 2015: 14 · 2014: 16 · 2013: 15 · 2012: 16
- FWCI
- 7.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Trends in Biochemical Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › 14-3-3 protein interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Structure and Dynamics
- Keywords
- WW domain, dystrophin, Nedd4-2, HECT ubiquitin ligase, 14-3-3 proteins, protein-protein interaction, protein conformational change, ubiquitination, signal transduction, protein mobility, catalytic domain
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Humans, Molecular Sequence Data, Repetitive Sequences, Nucleic Acid, Saccharomyces cerevisiae, Tryptophan, Signal Transduction, Dystrophin, Sequence Alignment, Conserved Sequence, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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