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Activity of thiols as singlet molecular oxygen quenchers
Abstract
Singlet molecular oxygen O2(1 delta g) arising from the thermodissociation of the endoperoxide of 3,3'-(1,4-naphthylidene) dipropionate (NDPO2) was used to assess the quenching ability of various thiols and related compounds in sodium phosphate buffer in D2O at 37 degrees C. The overall quenching ability decreases in the sequence ergothioneine, methionine, cysteine, beta,beta-dimethyl cysteine (penicillamine), mercaptopropionylglycine, mesna, glutathione (GSH), dithiothreitol, N-acetyl cysteine and captopril. Cystine, glutathione disulphide, dimesna, methionine sulphone and methionine sulphoxide have no quenching effect. Comparison of the rate constants for physical (kq) with chemical (kr) quenching by thiols indicates that chemical reactivity accounts fully for their ability to quench O2(1 delta g), and pD dependence indicates that the thiolate anion reacts with O2(1 delta g). Loss of thiol groups, as exemplified by GSH, is not affected by the free radical scavengers superoxide dismutase and mannitol. However, sodium azide, a scavenger of O2(1 delta g), completely prevents NDPO2-induced thiol depletion. Depletion of GSH by NDPO2 is accompanied by the formation of its disulphide, sulphinate, sulphonate, sulphoxide and other products.
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“Although the literature is somewhat scattered and heterogeneous, it seems clear that as well as hydroxyl radicals(228–232), ERG can also react with and detoxify, or prevent the formation of, singlet oxygen(233–242), ozone(243), superoxide(231,241,244–246), peroxide(32,124,247,248), hypochlorite(32,232,249) and peroxynitrite(224,231,250,251).”
From The biology of ergothioneine, an antioxidant nutraceutical (2020) · cites this paper as [234]
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Cites
Meister, A., & Anderson, M. E. (1983) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.52.070183.003431 · Cited by 5,694
MORON, M., DePierre, J. W., & Mannervik, B. (1979) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(79)90289-7 · Cited by 4,251
Lycopene as the most efficient biological carotenoid singlet oxygen quencher
Mascio, P. D., Kaiser, S., & Sies, H. (1989) · Archives of Biochemistry and Biophysics · doi:10.1016/0003-9861(89)90467-0 · Cited by 2,238
Self-citationBiochemistry of Oxidative Stress
Sies, H. (1986) · Angewandte Chemie International Edition in English · doi:10.1002/anie.198610581 · Cited by 1,316
Self-citationReed, D. J., Babson, J. R., Beatty, P. W., Brodie, A. E., Ellis, W. W., & Potter, D. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90118-9 · Cited by 1,178
Chemistry of singlet oxygen. X. Carotenoid quenching parallels biological protection
Foote, C. S., Chang, Y. C., & Denny, R. W. (1970) · Journal of the American Chemical Society · doi:10.1021/ja00720a036 · Cited by 418
Solvent Deuterium Isotope Effects on Acid-Base Equilibria
Salomaa, P., Schaleger, L. L., & Long, F. A. (1964) · Journal of the American Chemical Society · doi:10.1021/ja01055a001 · Cited by 300
Singlet oxygen production by biological systems
Kanofsky, J. R. (1989) · Chemico-Biological Interactions · doi:10.1016/0009-2797(89)90059-8 · Cited by 259
Wefers, H., & Sies, H. (1983) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1983.tb07791.x · Cited by 229
Self-citation[59] Glutathione disulfide (GSSG) efflux from cells and tissues
Sies, H., & Akerboom, T. P. M. (1984) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(84)05062-x · Cited by 197
Self-citation
Cited by
Sorted by citations
Items 101–176 of 176
Comparison of methods for extraction of organic N monomers from soil microbial biomass
Warren, C. R. (2014) · Soil Biology and Biochemistry · doi:10.1016/j.soilbio.2014.11.005 · Cited by 24
Supported photosensitizers for the visible light activation of phenols towards oxygen
Pepe, E., Abbas, O., Rébufa, C., Simon, M., Lacombe, S., & Julliard, M. (2004) · Journal of Photochemistry and Photobiology A Chemistry · doi:10.1016/j.jphotochem.2004.06.019 · Cited by 24
W�hrle, D., Wendt, A., Weitemeyer, A., Stark, J., Spiller, W., Schneider, G., M�ller, S., Michelsen, U., Kliesch, H., Heuermann, A., et al. (1994) · Russian Chemical Bulletin · doi:10.1007/bf00700152 · Cited by 24
Greenwell, R. S., Nam, T., & Donohue, T. J. (2011) · Journal of Molecular Biology · doi:10.1016/j.jmb.2011.01.055 · Cited by 23
The influence of lipoic acid on adriamycin-induced hyperlipidemic nephrotoxicity in rats
Malarkodi, K. P., Balachandar, A. V., & Varalakshmi, P. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024175325850 · Cited by 23
Nishimura, H., Yasui, H., & Sakurai, H. (2006) · Experimental Dermatology · doi:10.1111/j.1600-0625.2006.00484.x · Cited by 22
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Thakur, A. K., & Rao, C. M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002688 · Cited by 21
Wada, K., Kamisaki, Y., Nakamoto, K., & Itoh, T. (1996) · European Journal of Pharmacology · doi:10.1016/0014-2999(95)00717-2 · Cited by 21
Antioxidant DL-alpha lipoic acid as an attenuator of adriamycin induced hepatotoxicity in rat model.
Anandakumar, P. P., Malarkodi, S. P., Sivaprasad, T. R., & Saravanan, G. D. (2007) · PubMed · Cited by 20
Transformation and detoxification of fluoroquinolone antibiotics by singlet oxygen: A review
Sadek, A. H. S., Xu, A., Hassan, G. K., Zhao, L., & Zhang, Y. (2025) · Separation and Purification Technology · doi:10.1016/j.seppur.2025.135279 · Cited by 18
Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe
Murotomi, K., Umeno, A., Sugino, S., & Yoshida, Y. (2020) · Scientific Reports · doi:10.1038/s41598-020-67155-7 · Cited by 18
Oxygen Metabolism in Chloroplast
Ivanov, B. N., Kozuleva, M. A., & Borisova‐Mubarakshina, M. M. (2012) · InTech eBooks · doi:10.5772/27922 · Cited by 17
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Lebrun, V., Tron, A., Scarpantonio, L., Lebrun, C., Ravanat, J., Latour, J., McClenaghan, N. D., & Sénèque, O. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201405333 · Cited by 17
Red light-activated phosphorothioate oligodeoxyribonucleotides
Rotaru, A., Kovács, J., & Mokhir, A. A. (2008) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2008.06.079 · Cited by 17
Daimon, T., Hirakawa, T., & Nosaka, Y. (2008) · Electrochemistry · doi:10.5796/electrochemistry.76.136 · Cited by 17
Mitochondrial Permeability Transition Induced by Chemically Generated Singlet Oxygen
Cosso, R. G., Turim, J., Nantes, I. L., Almeida, A. M., Mascio, P. D., & Vercesi, A. E. (2002) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1016075218162 · Cited by 17
Sinbandhit-Tricot, S., Cillard, J., Chevanne, M., Morel, I., Cillard, P., & Sergent, O. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00108-4 · Cited by 17
The Blood Fibrinolysis/Deep-Sea Analogy
Stief, T. W. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00213-9 · Cited by 17
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Zhao, W., Dong, S.-L., Sun, L., Wang, Q., & Gai, H. (2014) · Chemistry - An Asian Journal · doi:10.1002/asia.201402453 · Cited by 16
Blázquez‐Castro, A., Breitenbach, T., & Ogilby, P. R. (2018) · Photochemical & Photobiological Sciences · doi:10.1039/c8pp00338f · Cited by 16
Photocleavage of plasmid DNA by the prophyrin meso-tetrakis[4-(carboxymethyleneoxy)phenyl]porphyrin
Chatterjee, S. R., Shetty, S. J., Devasagayam, T. P. A., & Srivastava, T. S. (1997) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(97)00094-8 · Cited by 16
Self-citationGagandeep, Dhiman, M., Mendiz, E., Rao, A. R., & Kale, R. K. (2005) · Human & Experimental Toxicology · doi:10.1191/0960327105ht526oa · Cited by 15
ORTWERTH, B. J., Coots, A., James, H. L., & Linetsky, M. D. (1998) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1997.0549 · Cited by 15
Chatterjee, S., Biswas, G., Chandra, S., Saha, G., & Acharya, K. (2014) · Cited by 14
A straightforward preparation of a polystyrene thiol resin
Becht, J., Wagner, A., & Mioskowski, C. (2004) · Tetrahedron Letters · doi:10.1016/j.tetlet.2004.07.147 · Cited by 14
Zhi, W., Zou, J., Li, S., He, L., Li, Q., Zhou, Z., Huang, Y.-H., Zhi-min, Y., & Ma, J. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.157548 · Cited by 13
Sarma, L. (1996) · International Journal of Radiation Biology · doi:10.1080/095530096145643 · Cited by 13
Deadwyler, G., Sima, P. D., Fu, Y., & Kanofsky, J. R. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb01939.x · Cited by 13
Concept and Evolution of the Atherton-Todd Reaction
Fang, S., Liu, Z., Su, Z., & Wang, T. (2025) · ACS Catalysis · doi:10.1021/acscatal.5c02396 · Cited by 12
Garlic Extract Ameliorates Renal and Cardiopulmonary Injury in the Rats with Chronic Renal Failure
Deniz, M., Şener, G., Ercan, F., & Yeğen, B. Ç. (2011) · Renal Failure · doi:10.3109/0886022x.2011.589952 · Cited by 12
Sobek, J., & Schlapbach, R. (2020) · Molecules · doi:10.3390/molecules25225369 · Cited by 13
Davies, M. J. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100052 · Cited by 11
Díaz‐Uribe, C., Vallejo, W., la Hoz, T. D., Flórez, J., Muñoz-Acevedo, A., Zárate, X., & Schott, E. (2021) · Chemical Papers · doi:10.1007/s11696-021-01825-2 · Cited by 11
Lebrun, V., Tron, A., Lebrun, C., Latour, J., McClenaghan, N. D., & Sénèque, O. (2015) · Chemistry - A European Journal · doi:10.1002/chem.201501749 · Cited by 13
[21] Biological singlet oxygen quenchers assessed by monomol light emission
Briviba, K., & Sies, H. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)19023-8 · Cited by 11
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Peng, T., Kan, J., Lun, J., & Hu, Z. (2018) · Journal of Fish Diseases · doi:10.1111/jfd.12926 · Cited by 10
Chabert, V., Lebrun, V., Lebrun, C., Latour, J., & Sénèque, O. (2019) · Chemical Science · doi:10.1039/c9sc00341j · Cited by 11
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Blázquez‐Castro, A., Westberg, M., Bregnhøj, M., Breitenbach, T., Mogensen, D. J., Etzerodt, M., & Ogilby, P. R. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-818606-0.00019-5 · Cited by 10
Mogensen, D. J., Westberg, M., Breitenbach, T., Etzerodt, M., & Ogilby, P. R. (2021) · Photochemistry and Photobiology · doi:10.1111/php.13440 · Cited by 9
Uchida, A., Onoue, S., Ohtake, H., Seto, Y., Teramatsu, T., Terajima, T., & Oguchi, T. (2015) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.24689 · Cited by 9
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Pecci, L., Montefoschi, G., Antonucci, A. M., Costa, M., & Cavallini, D. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)03063-2 · Cited by 8
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Varalakshmi, P., Sandhya, S., & Malarkodi, K. P. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1024141128546 · Cited by 8
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Zheng, L., & Greenberg, M. M. (2020) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.0c01095 · Cited by 7
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Tank, R., Pathak, U., Singh, A., Gupta, A. K., & Gupta, D. C. (2009) · Reactive and Functional Polymers · doi:10.1016/j.reactfunctpolym.2008.12.022 · Cited by 7
Gao, Q., Hägglund, P., Gamon, L. F., & Davies, M. J. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.04.011 · Cited by 6
Ahn, J., & Chung, P. (2012) · General Physiology and Biophysics · doi:10.4149/gpb_2012_040 · Cited by 6
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Packer, L. (1996) · AOCS Publishing eBooks · doi:10.1201/9781439832059.ch23 · Cited by 6
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Peres, P. S., Valerio, A., Cadena, S. M. S. C., Winnischofer, S. M. B., Scalfo, A. C., Mascio, P. D., & Martinez, G. R. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.09.020 · Cited by 5
Calvo, G. H., Céspedes, M. A., Casas, A. G., Venosa, G. M. D., & Sáenz, D. A. (2022) · Nitric Oxide · doi:10.1016/j.niox.2022.06.006 · Cited by 5
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Goyal, M., Kumari, A., Kumari, A., Sharma, H., Vasmatkar, P., & Gupta, N. S. (2023) · Springer eBooks · doi:10.1007/978-981-99-1858-4_6 · Cited by 4
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von Montfort, C. (2004) · Univ. Duesseldorf: Duesseldorfer Dokumenten- und Publikationsserver
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Wang, C., Zhang, H., Zhang, T., Zou, X., Wang, H., Rosenberger, J. E., Vannam, R., Trout, W., Jia, X., Li, Z., et al. (2021) · ChemRxiv · doi:10.26434/chemrxiv.13513215
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Zhao, S., Li, J., Duan, S., Liu, C., Wang, H., Lu, J., Zhao, N., Sheng, X., Wu, Y., Li, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26074137
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Metadata
- Authors
- Devasagayam, T. P. A., Sundquist, A. R., Di Mascio, P., Kaiser, S., & Sies, H.
- Affiliations
- Heinrich Heine University Düsseldorf (DE)
- Corresponding author
- Sies, Helmut
- ORCID
- Sies, Helmut
- Venue
- Journal of Photochemistry and Photobiology B: Biology
- Publisher
- Elsevier BV
- Published
- 1991-04
- Volume
- 9
- Issue
- 1
- Pages
- 105-116
- ISSN
- 1011-1344 (ISSN-L)
- OpenAlex
- W1997822338
- Cited by
- 175
- References
- 34
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 8 · 2020: 9 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 10 · 2013: 6 · 2012: 6
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Photochemistry and Photobiology B Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Physical Sciences › Chemistry › Organic Chemistry › Free Radicals and Antioxidants
- Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
- Keywords
- singlet oxygen, glutathione depletion, glutathione disulfide, chemical quenching, physical quenching, thiolate anion, sodium azide, superoxide dismutase, mannitol, mesna, N-acetylcysteine, cysteine, methionine, ergothioneine, D-penicillamine, dithiothreitol, captopril
- MeSH terms
- Glutathione, Oxidation-Reduction, Oxygen, Photochemistry, Sulfhydryl Compounds, Singlet Oxygen
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