Effects of weightlessness on bone mass and osteoclast number in pregnant rats after a five-day spaceflight (COSMOS 1514)
Abstract
Five pregnant growing rats were orbited for 5 days aboard the Soviet COSMOS 1514 biologic satellite. The bone effects of weightlessness were studied and compared to those of five pregnant rats kept in vivarium and five pregnant conditioned rats. Bone histomorphometric studies were performed to investigate the early effects of weightlessness in loaded (tibia-femur) and unloaded (thoracic and lumbar vertebrae) bones. A short exposure to weightlessness does not induce any change in bone mass and inner structure in either type of bone. In unloaded bones, the number of osteoclasts per square millimeter of the trabecular surface significantly increased when measured after histochemical demonstration of tartrate-resistant acid phosphatase. It is likely that a stimulation of bone resorption activity occurs in the trabeculae of unloaded bones during the early phase of a spaceflight. In tibia, osteoid seam thickness and total osteoclastic resorption surfaces at the endosteal level were not modified.
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Five days of spaceflight aboard the COSMOS 1514 biologic satellite increased the number of TRAP-positive osteoclasts per mm2 of thoracic and lumbar vertebrae.
“Using similar methods, the same investigators had previously shown that 5 days of spaceflight aboard the COSMOS 1514 biologic satellite increased the number of TRAP-positive osteoclasts per mm2 of thoracic and lumbar vertebrae [58]”
From Osteoclasts and Microgravity (2020) · cites this paper as [58]
Conditions of microgravity and simulated microgravity decrease osteoblastogenesis and osteoblast secretion of OPG.
“decrease osteoblastogenesis and osteoblast secretion of OPG”
From Osteoclasts and Microgravity (2020) · cites this paper as [58]
Conditions of microgravity and simulated microgravity decrease the mineral content and cortical and trabecular microstructures of bone.
“conditions of microgravity and simulated microgravity decrease the mineral content and cortical and trabecular microstructures of bone”
From Osteoclasts and Microgravity (2020) · cites this paper as [58]
Conditions of microgravity and simulated microgravity increase osteoclast secretion of sclerostin.
“increase osteoclast secretion of sclerostin”
From Osteoclasts and Microgravity (2020) · cites this paper as [58]
Conditions of microgravity and simulated microgravity increase osteoclast differentiation, fusion, and expression of regulatory and osteoclast-specific genes.
“increase osteoclast differentiation, fusion, and expression of regulatory and osteoclast-specific genes”
From Osteoclasts and Microgravity (2020) · cites this paper as [58]
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Smith, J. K. (2020) · Life · doi:10.3390/life10090207 · Cited by 52 · see citing works
- Authors
- Vico, L., Chappard, D., Alexandre, C., Palle, S., Minaire, P., Riffat, G., Novikov, V. E., & Bakulin, A. V.
- Affiliations
- Université Jean Monnet (FR)
- Corresponding author
- Vico, L.
- ORCID
- Venue
- Bone
- Publisher
- Elsevier BV
- Published
- 1987-01
- Volume
- 8
- Issue
- 2
- Pages
- 95-103
- ISSN
- 1873-2763 (ISSN-L)
- 8756-3282
- OpenAlex
- W2014949982
- Cited by
- 69
- References
- 0
- Citations by year
- 2026: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 3 · 2016: 1 · 2015: 4 · 2014: 1 · 2012: 1
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bone (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Keywords
- microgravity, bone mass, osteoclasts, bone resorption, pregnancy, spaceflight, bone histomorphometry, trabecular bone, osteoid seams, tartrate-resistant acid phosphatase, rats
- MeSH terms
- Acid Phosphatase, Animals, Bone and Bones, Bone Resorption, Cell Count, Female, Osteoblasts, Osteoclasts, Pregnancy, Rats, Inbred Strains, Space Flight, Weightlessness, Rats
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