Therapeutic Applications of Iminosugars: Current Perspectives and Future Opportunities

TGF-β SIGNAL TRANSDUCTION

Massagué, J. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.753 · Cited by 7,571

Biological roles of oligosaccharides: all of the theories are correct

Varki, A. P. (1993) · Glycobiology · doi:10.1093/glycob/3.2.97 · Cited by 5,229

Glycosylation in Cellular Mechanisms of Health and Disease

Ohtsubo, K., & Marth, J. D. (2006) · Cell · doi:10.1016/j.cell.2006.08.019 · Cited by 2,818

Glycobiology: Toward Understanding the Function of Sugars

Dwek, R. A. (1996) · Chemical Reviews · doi:10.1021/cr940283b · Cited by 2,800

Essentials of Glycobiology

Varki, A. P., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Bertozzi, C. R., Hart, G. W., & Etzler, M. E. (1999) · Cited by 2,384

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

Buée, L., Bussière, T., Buée‐Scherrer, V., Delacourte, A., & Hof, P. R. (2000) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00019-9 · Cited by 2,142

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

Sidransky, E., Nalls, M. A., Aasly, J. O., Aharon-Peretz, J., Annesi, G., Barbosa, E. R., Bar-Shira, A., Berg, D., Bras, J., Brice, A., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0901281 · Cited by 2,135

Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds

Spiro, R. G. (2002) · Glycobiology · doi:10.1093/glycob/12.4.43r · Cited by 1,414

GLYCOBIOLOGY

Rademacher, T. W., Parekh, R. B., & Dwek, R. A. (1988) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.57.070188.004033 · Cited by 1,144

Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.

Hakomori, S. (1996) · PubMed · Cited by 987

Iminosugars as Therapeutic Agents: Recent Advances and Promising Trends

Nash, R. J., Kato, A., Yu, C.-Y., & Fleet, G. W. J. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.117 · Cited by 302

Carbohydrate based Potential Chemotherapeutic Agents: Recent Developments and their Scope in Future Drug Discovery

Tiwari, V. K., Mishra, R. C., Sharma, A., & Tripathi, R. P. (2012) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/138955712803832654 · Cited by 97

The Multivalent Effect in Glycosidase Inhibition: Probing the Influence of Valency, Peripheral Ligand Structure, and Topology with Cyclodextrin‐Based Iminosugar Click Clusters

Decroocq, C., Joosten, A. Y. P., Sergent, R., Barragán, T. M., Mellet, C. O., & Compain, P. (2013) · ChemBioChem · doi:10.1002/cbic.201300283 · Cited by 61

Looking-Glass Synergistic Pharmacological Chaperones: DGJ and L-DGJ from the Enantiomers of Tagatose

Jenkinson, S. F., Fleet, G. W. J., Nash, R. J., Koike, Y., Adachi, I., Yoshihara, A., Morimoto, K., Izumori, K., & Kato, A. (2011) · Organic Letters · doi:10.1021/ol201552q · Cited by 56

Access to l - and d -Iminosugar C-Glycosides from a d -gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

Mondon, M., Fontelle, N., Désiré, J., Lecornué, F., Guillard, J., Marrot, J., & Blériot, Y. (2012) · Organic Letters · doi:10.1021/ol203385w · Cited by 47

Carbohydrate-Based Therapeutics

Mishra, S., Upadhaya, K., Mishra, K. B., Shukla, A. K., Tripathi, R. P., & Tiwari, V. K. (2016) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63601-0.00010-7 · Cited by 47

Recent developments in targeting protein misfolding diseases

Denny, R. A., Gavrin, L. K., & Saiah, E. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.01.089 · Cited by 48

Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design

Hevey, R. (2019) · Biomimetics · doi:10.3390/biomimetics4030053 · Cited by 44

Polyhydroxyamino‐Piperidine‐Type Iminosugars and Pipecolic Acid Analogues from a D ‐Mannose‐Derived Aldehyde

Matassini, C., Mirabella, S., Ferhati, X., Faggi, C., Robina, I., Goti, A., Moreno‐Clavijo, E., Moreno‐Vargas, A. J., & Cardona, F. (2014) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201402427 · Cited by 40

Inhibition of Nonmammalian Glycosidases by Azetidine Iminosugars Derived from Stable 3,5-Di-O-triflates of Pentoses

Lenagh‐Snow, G. M. J., Araújo, N., Jenkinson, S. F., Rutherford, C., Nakagawa, S., Kato, A., Yu, C., Weymouth‐Wilson, A. C., & Fleet, G. W. J. (2011) · Organic Letters · doi:10.1021/ol2024482 · Cited by 40

Synthesis and Evaluation of Eight- and Four-Membered Iminosugar Analogues as Inhibitors of Testicular Ceramide-Specific Glucosyltransferase, Testicular β-Glucosidase 2, and Other Glycosidases

Lee, J. C., Francis, S., Dutta, D., Gupta, V. G., Yang, Y., Zhu, J.-Y., Tash, J. S., Schönbrunn, E., & Georg, G. I. (2012) · The Journal of Organic Chemistry · doi:10.1021/jo202054g · Cited by 38

Synthesis and Glycosidase Inhibition Studies of 5‐Methyl‐Substituted Tetrahydroxyindolizidines and ‐pyrrolizidines Related to Natural Hyacinthacines B

Martella, D., Cardona, F., Parmeggiani, C., Franco, F., Tamayo, J. A., Robina, I., Moreno‐Clavijo, E., Moreno‐Vargas, A. J., & Goti, A. (2013) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201300103 · Cited by 35

Square sugars: challenges and synthetic strategies

Hazelard, D., & Compain, P. (2017) · Organic & Biomolecular Chemistry · doi:10.1039/c7ob00386b · Cited by 35

One-Pot Synthesis of Structurally Diverse Iminosugar-Based Hybrid Molecules

Prasad, S. S., Narra, R. R., & Baskaran, S. (2018) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.8b00748 · Cited by 36

Iminosugar C-Glycoside Analogues of α- d -GlcNAc-1-Phosphate: Synthesis and Bacterial Transglycosylase Inhibition

Hsu, C.-H., Schelwies, M., Enck, S., Huang, L., Huang, S., Chang, Y., Cheng, T.-J. R., Cheng, W., & Wong, C. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo501340s · Cited by 33

N- and C-alkylation of seven-membered iminosugars generates potent glucocerebrosidase inhibitors and F508del-CFTR correctors

Désiré, J., Mondon, M., Fontelle, N., Nakagawa, S., Hirokami, Y., Adachi, I., Iwaki, R., Fleet, G. W. J., Alonzi, D. S., Twigg, G., et al. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00325j · Cited by 30

Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors

Arora, I., Kashyap, V. K., Singh, A., Dasgupta, A., Kumar, B. N., & Shaw, A. K. (2014) · Organic & Biomolecular Chemistry · doi:10.1039/c4ob00486h · Cited by 29

Design, synthesis and photochemical properties of the first examples of iminosugar clusters based on fluorescent cores

Lepage, M. L., Mirloup, A., Ripoll, M., Stauffert, F., Bodlenner, A., Ziessel, R. F., & Compain, P. (2015) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.11.74 · Cited by 26

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Blériot, Y., Trần, A. T., Prencipe, G., Jagadeesh, Y., Auberger, N., Zhu, S., Gauthier, C., Zhang, Y., Désiré, J., Adachi, I., et al. (2014) · Organic Letters · doi:10.1021/ol502929h · Cited by 26

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Azad, C. S., & Saxena, A. K. (2015) · Organic Chemistry Frontiers · doi:10.1039/c5qo00019j · Cited by 25

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Kumar, K. S. A., Rathee, J. S., Subramanian, M., & Chattopadhyay, S. (2013) · The Journal of Organic Chemistry · doi:10.1021/jo400448p · Cited by 23

Piperidine Azasugars Bearing Lipophilic Chains: Stereoselective Synthesis and Biological Activity as Inhibitors of Glucocerebrosidase (GCase)

Clemente, F., Matassini, C., Giachetti, S., Goti, A., Morrone, A., Martínez‐Bailén, M., Orta, S., Merino, P., & Cardona, F. (2021) · The Journal of Organic Chemistry · doi:10.1021/acs.joc.1c01308 · Cited by 22

Synthesis of three branched iminosugars [(3R,4R,5S)-3-(hydroxymethyl)piperidine-3,4,5-triol, (3R,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol and (3S,4R,5R)-3-(hydroxymethyl)piperidine-3,4,5-triol] and a branched trihydroxynipecotic acid [(3R,4R,5R)-3,4,5-trihydroxypiperidine-3-carboxylic acid] from sugar lactones with a carbon substituent at C-2

Simone, M. I., Soengas, R. G., Jenkinson, S. F., Evinson, E. L., Nash, R. J., & Fleet, G. W. J. (2012) · Tetrahedron Asymmetry · doi:10.1016/j.tetasy.2012.03.007 · Cited by 21

Design, synthesis and glycosidase inhibition studies of novel triazole fused iminocyclitol-δ-lactams

Santhanam, V., Pant, P., Jayaram, B., & Ramesh, N. G. (2019) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob03084g · Cited by 20

Gold nanoparticles are suitable cores for building tunable iminosugar multivalency

Matassini, C., Marradi, M., Cardona, F., Parmeggiani, C., Robina, I., Moreno‐Vargas, A. J., Penadés, S., & Goti, A. (2015) · RSC Advances · doi:10.1039/c5ra22152h · Cited by 20

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20

Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies

Gavale, K. S., Chavan, S. R., Khan, A., Joshi, R. S., & Dhavale, D. D. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob00668f · Cited by 19

Synthesis, Conformational Analysis, and Complexation Study of an Iminosugar-Aza-Crown, a Sweet Chiral Cyclam Analog

Bordes, A., Poveda, A. M., Troadec, T., Franconetti, A., Ardá, A., Perrin, F., Ménand, M., Sollogoub, M., Guillard, J., Désiré, J., et al. (2020) · Organic Letters · doi:10.1021/acs.orglett.0c00503 · Cited by 19

Iminosugars: Therapeutic Applications and Synthetic Considerations

Horne, G. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_50 · Cited by 20

Asymmetric Syntheses of (−)-3-epi-Fagomine, (2R,3S,4R)-Dihydroxypipecolic Acid, and Several Polyhydroxylated Homopipecolic Acids

Csatayová, K., Davies, S. G., Fletcher, A. M., Ford, J. G., Klauber, D. J., Roberts, P. M., & Thomson, J. E. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo501952t · Cited by 17

One-pot strategy: A highly economical tool in organic synthesis and medicinal chemistry

Yadav, R. N., Srivastava, A. K., & Banik, B. K. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817592-7.00010-1 · Cited by 19

Synthesis of a new class of iminosugars based on constrained azaspirocyclic scaffolds by way of catalytic C–H amination

Nocquet, P., Hensienne, R., Wencel‐Delord, J., Wimmer, E., Hazelard, D., & Compain, P. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01254f · Cited by 17

Stable analogues of nojirimycin – synthesis and biological evaluation of nojiristegine and manno-nojiristegine

Viuff, A. H., Besenbacher, L. M., Kamori, A., Jensen, M. T., Kilian, M., Kato, A., & Jensen, H. H. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01281c · Cited by 16

Synthesis and glycosidase inhibition potency of all- trans substituted 1- C -perfluoroalkyl iminosugars

Massicot, F., Plantier‐Royon, R., Vasse, J., & Behr, J. (2018) · Carbohydrate Research · doi:10.1016/j.carres.2018.05.004 · Cited by 16

Stereocontrolled synthesis of polyhydroxylated bicyclic azetidines as a new class of iminosugars

Malinowski, M., Hensienne, R., Kern, N., Tardieu, D., Bodlenner, A., Hazelard, D., & Compain, P. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob01065j · Cited by 15

Structure–Activity Studies of N‐Butyl‐1‐deoxynojirimycin (NB‐DNJ) Analogues: Discovery of Potent and Selective Aminocyclopentitol Inhibitors of GBA1 and GBA2

Gu, X., Gupta, V. G., Yang, Y., Zhu, J., Carlson, E. J., Kingsley, C. N., Tash, J. S., Schönbrunn, E., Hawkinson, J. E., & Georg, G. I. (2017) · ChemMedChem · doi:10.1002/cmdc.201700558 · Cited by 15

Cell viability assay as a tool to study activity and inhibition of hepatitis C p7 channels

Breitinger, U., Farag, N. S., Ali, N. K. M., Ahmed, M., El-Azizi, M., & Breitinger, H. (2021) · Journal of General Virology · doi:10.1099/jgv.0.001571 · Cited by 14

Stereospecific Cyclization Strategies for α,ε-Dihydroxy-β-amino Esters: Asymmetric Syntheses of Imino and Amino Sugars

Davies, S. G., Foster, E. M., Lee, J. A., Roberts, P. M., & Thomson, J. E. (2014) · The Journal of Organic Chemistry · doi:10.1021/jo5018298 · Cited by 14

Diversity‐Oriented Synthesis and Biological Evaluation of Iminosugars from Unprotected 2‐Deoxy‐ d ‐ribose

Malinowski, M., Rowicki, T., Guzik, P., Wielechowska, M., Sobiepanek, A., & Sas, W. (2016) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201600459 · Cited by 14

N‐Thiocarbonyl Iminosugars: Synthesis and Evaluation of Castanospermine Analogues Bearing Oxazole‐2(3H)‐thione Moieties

Silva, S., Sánchez‐Fernández, E. M., Mellet, C. O., Tatibouët, A., Rauter, A. P., & Rollin, P. (2013) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201300720 · Cited by 14

[1,4]-sigmatropic rearrangement of chiral nitrones and their utilization in the synthesis of new iminosugars

Malinowski, M., Rowicki, T., Guzik, P., Gryszel, M., Łapczyński, S., Wielechowska, M., Czerwińska, K., Madura, I. D., & Sas, W. (2015) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob01432h · Cited by 14

Synthesis of branched seven-membered 1-N-iminosugars and their evaluation as glycosidase inhibitors

Li, H., Zhang, Y., Favre, S., Vogel, P., Sollogoub, M., & Blériot, Y. (2011) · Carbohydrate Research · doi:10.1016/j.carres.2011.10.039 · Cited by 14

Conformationally constrained fused bicyclic iminosugars: synthetic challenges and opportunities

Hensienne, R., Hazelard, D., & Compain, P. (2019) · ARKIVOC · doi:10.24820/ark.5550190.p010.872 · Cited by 13

Aglycone mimics for tuning of glycosidase inhibition: design, synthesis and biological evaluation of bicyclic pyrrolidotriazole iminosugars

Arora, I., Sharma, S. K., & Shaw, A. K. (2016) · RSC Advances · doi:10.1039/c5ra26005a · Cited by 12

Pushing the limits of catalytic C–H amination in polyoxygenated cyclobutanes

Nocquet, P., Hensienne, R., Wencel‐Delord, J., Laigre, E., Sidelarbi, K., Becq, F., Norez, C., Hazelard, D., & Compain, P. (2016) · Organic & Biomolecular Chemistry · doi:10.1039/c5ob02602d · Cited by 12

2‐Acetamido‐2‐deoxy‐ l ‐iminosugar C‐Alkyl and C‐Aryl Glycosides: Synthesis and Glycosidase Inhibition

Fontelle, N., Yamamoto, A., Ardá, A., Jiménez‐Barbero, J., Kato, A., Désiré, J., & Blériot, Y. (2018) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201800678 · Cited by 12

Skeletal rearrangement of seven-membered iminosugars: Synthesis of (−)-adenophorine, (−)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors

Mondon, M., Lecornué, F., Guillard, J., Nakagawa, S., Kato, A., & Blériot, Y. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.035 · Cited by 12

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Kothari, S. C., Saravana, M., Muthusamy, S., Mozingo, A., & Soni, M. G. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.10.014 · Cited by 11

Synthesis, α-mannosidase inhibition studies and molecular modeling of 1,4-imino-ᴅ-lyxitols and their C-5-altered N -arylalkyl derivatives

Kalník, M., Šesták, S., Kóňa, J., Bella, M., & Poláková, M. (2023) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.19.24 · Cited by 10

Selective Golgi α-mannosidase II inhibitors: N -alkyl substituted pyrrolidines with a basic functional group

Klunda, T., Hricovíni, M., Šesták, S., Kóňa, J., & Poláková, M. (2021) · New Journal of Chemistry · doi:10.1039/d1nj01176f · Cited by 10

Stereoselective synthesis and biological evaluation of d-fagomine, d-3-epi-fagomine and d-3,4-epi-fagomine analogs from d-glyceraldehyde acetonide as a common building block

Díez, J. A., Galvez, J. A., Diaz-De-Villegas, M. D., Badorrey, R., BARTHOLOMEW, B. A., & Nash, R. J. (2012) · Organic & Biomolecular Chemistry · doi:10.1039/c2ob26732b · Cited by 10

(3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose

Martínez, R. F., Araújo, N., Jenkinson, S. F., Nakagawa, S., Kato, A., & Fleet, G. W. J. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.03.004 · Cited by 10

A novel rare sugar inhibitor of murine herpes simplex keratitis

Muniruzzaman, S., McIntosh, M., Hossain, A., Izumori, K., & Bhattacharjee, P. S. (2016) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2016.05.004 · Cited by 10

Improvement of a gas chromatographic method for the analysis of iminosugars and other bioactive carbohydrates

Rodríguez-Sánchez, S., Soria, A. C., Ruiz‐Matute, A. I., & Sanz, M. L. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.03.013 · Cited by 9

Synthesis and biological evaluation of α-1-C-4′-arylbutyl-l-arabinoiminofuranoses, a new class of α-glucosidase inhibitors

Natori, Y., Sakuma, T., Yoshimura, Y., Kinami, K., Hirokami, Y., Sato, K., Adachi, I., Kato, A., & Takahata, H. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.06.001 · Cited by 9

ASYMMETRIC SYNTHESIS OF 1-ALKYL-2-DEOXYIMINOFURANOSES VIA THE IRIDIUM-CATALYZED INTRAMOLECULAR CYCLIZATION OF AN ALLYLIC CARBONATE

Takahata, H., Natori, Y., Kikuchi, S., Yoshimura, Y., Kato, A., & Adachi, I. (2012) · Heterocycles · doi:10.3987/com-12-s(n)99 · Cited by 9

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Debbah, Z., Marrot, J., Auberger, N., Désiré, J., & Blériot, Y. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c01560 · Cited by 9

Contributing to the Study of Enzymatic and Chemical Glycosyl Transfer Through the Observation and Mimicry of Glycosyl Cations

Blériot, Y. (2020) · Synthesis · doi:10.1055/s-0040-1706073 · Cited by 8

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Dashnyam, P., Lin, H., Chen, C.-Y., Gao, S., Yeh, L.-F., Hsieh, W., Tu, Z., & Lin, C. (2020) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01918 · Cited by 8

Conformationally Restricted Oxazolidin‐2‐one Fused Bicyclic Iminosugars as Potential Glycosidase Inhibitors

Domingues, M. A. D. G., Jaszczyk, J., Ismael, M. I., Figueiredo, J. A., Daniellou, R., Lafite, P., Schuler, M., & Tatibouët, A. (2020) · European Journal of Organic Chemistry · doi:10.1002/ejoc.202001053 · Cited by 8

Molecular networking-guided investigation of the secondary metabolome of four Morus species and their in vivo neuroprotective potential for the mitigation of Alzheimer's disease

Hegazi, N. M., Mohamed, T. A., Salama, A., Hamed, A. R., Saad, H. H., Saleh, I. A., Reda, E. H., El‐Sayed, A. A., Ibrahim, M. A. A., Paré, P. W., et al. (2024) · Food & Function · doi:10.1039/d3fo05711a · Cited by 7

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Compain, P. (2023) · Synlett · doi:10.1055/s-0042-1751449 · Cited by 7

Ketenimine mediated synthesis of lactam iminosugars: development of one-pot process via tandem hydrative amidation of amino-alkynes and intramolecular transamidation

Arora, I., & Shaw, A. K. (2016) · Tetrahedron · doi:10.1016/j.tet.2016.07.036 · Cited by 7

Chiron approach strategy to the bicyclic oxazolidinylpiperidine: a building block for preparing mono- and bi-cyclic iminosugars

Kalamkar, N. B., & Dhavale, D. D. (2011) · Tetrahedron Letters · doi:10.1016/j.tetlet.2011.09.039 · Cited by 6

Spiro Iminosugars: Structural Diversity and Synthetic Strategies

Hazelard, D., Hensienne, R., Behr, J., & Compain, P. (2019) · Topics in heterocyclic chemistry · doi:10.1007/7081_2019_29 · Cited by 5

The Antibacterial and Immunomodulatory Effects of Carbohydrate Fractions of the Seaweed Gracilaria persica

Khosravi, M., Gharibi, D., Kaviani, F., & Mohammadidust, M. (2018) · Journal of Medical Microbiology and Infectious Diseases · doi:10.29252/jommid.6.2.3.57 · Cited by 4

Design, synthesis, and preliminary immunopotentiating activity of new analogues of nojirimycin

Thangarasu, A. K., Sambyal, S., Kumar, H. M. S., & Lankalapalli, R. S. (2021) · Carbohydrate Research · doi:10.1016/j.carres.2021.108479 · Cited by 5

Catalytic asymmetric synthesis of stereoisomers of 1-C-n-butyl-LABs for the SAR study of α-glucosidase inhibition

Natori, Y., Sakuma, T., Watanabe, H., Wakamatsu, H., Kato, A., Adachi, I., Takahata, H., & Yoshimura, Y. (2019) · Tetrahedron · doi:10.1016/j.tet.2019.04.003 · Cited by 4

Bi(OTf)3-mediated intramolecular epoxide opening for bicyclic azepane synthesis

Zhu, S., Trần, A. T., Hirokami, Y., Gontard, G., Khaled, O., Zhang, Y., Kato, A., Blériot, Y., & Sollogoub, M. (2019) · Journal of Carbohydrate Chemistry · doi:10.1080/07328303.2019.1581887 · Cited by 3

Synthetic 1‐Deoxynojirimycin N‐Substituted Peptides Offer Prolonged Disruption to N‐Linked Glycan Processing

Aguilar, A. L., Escribano, J., Wentworth, P., & Butters, T. D. (2014) · ChemMedChem · doi:10.1002/cmdc.201402186 · Cited by 3

Synthesis of L-Iminofuranoses and Their Biological Evaluations

Natori, Y. (2020) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.20-00194 · Cited by 3

The Ugi–Joullié three-component reaction (UJ-3CR) and related reactions: recent developments, mechanistic aspects and synthesis of natural products and bioactive compounds

D'emilio, N. A. L., Armero, P. K. P., Salgado, A. R. M., Simonetti, S. O., Bracca, A. B. J., Larghi, E. L., & Kaufman, T. S. (2026) · Organic & Biomolecular Chemistry · doi:10.1039/d5ob02009c · Cited by 2

Stereoselective Synthesis of Heavily Hydroxylated Azepane Iminosugars via Osmium-Catalyzed Tethered Aminohydroxylation

Martínez‐Bailén, M., Matassini, C., Clemente, F., Faggi, C., Goti, A., & Cardona, F. (2023) · Organic Letters · doi:10.1021/acs.orglett.3c02087 · Cited by 2

Recent synthetic strategies to access diverse iminosugars

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Alkylation studies of a polyhydroxylated-cyano-piperidine scaffold

Dilmaç, A. M., Tite, T., Tsimilaza, A., Lemoine, P., Boutefnouchet, S., Michel, S., & Lallemand, M. (2014) · ARKIVOC · doi:10.3998/ark.5550190.p008.243 · Cited by 2

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Sumit, S., & Aidhen, I. S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91729-2.00011-2 · Cited by 2

Total synthesis of N-butyl-1-deoxynojirimycin

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An Improved Synthetic Method for N-Butyl-1-Deoxynojirimycin

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Vergara-Arenas, B. I. (2019) · doi:10.24275/uami.ms35t8841

Endophytic fungi and age-related diseases: Potential for geriatric therapeutics

Karmakar, R., Kumar, S., Tripathi, V. S., Sharma, P. K., Kumar, R., & Sharma, R. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-31484-1.00014-1

Addition of Lithiated 1,3-Dithiane and Nitronate to Sugar-Derived Imines: Synthesis of Homoiminosugars and Pipecolic Acid Analogues

Tran, T. V., Marrot, J., Yamamoto, S., Yoshimura, K., Gillaizeau, I., Nicolas, C., Désiré, J., Kato, A., Auberger, N., & Blériot, Y. (2025) · Organic Letters · doi:10.1021/acs.orglett.5c01061

Pharmaceutical aspects of conventional and recent developments for the treatment of metabolic diseases and disorders

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Petasis-mediated exo-iminoglycals synthesis from glyconolactams allows access to unprecedented 1-spirocyclopropyl deoxynojirimycin

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Merieux, G. (2019) · doi:10.70675/cac6c93czac01z4b62z90b3zae5d367c0a5f

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Pichon, M. M. (2018) · doi:10.70675/188598bez81f6z474az82a2zb1174d769b09

BindingDB Entry 50043216: Skeletal rearrangement of seven-membered iminosugars: synthesis of (-)-adenophorine, (-)-1-epi-adenophorine and derivatives and evaluation as glycosidase inhibitors.

BindingDB (2014) · UC San Diego · doi:10.7270/q2gq7053

BindingDB Entry 50007650: Substituent Position of Iminocyclitols Determines the Potency and Selectivity for Gut Microbial Xenobiotic-Reactivating Enzymes.

BindingDB (2021) · UC San Diego · doi:10.7270/q2cj8htj

BindingDB Entry 50043215: (3R,4S,5R,6R,7S)-3,4,5,7-Tetrahydroxyconidine, an azetidine analogue of 6,7-diepicastanospermine and a conformationally constrained d-deoxyaltronojirimycin, from l-arabinose.

BindingDB (2014) · UC San Diego · doi:10.7270/q2mg7qxg

BindingDB Entry 50045168: Synthesis and biological evaluation ofa-1-C-4'-arylbutyl-L-arabinoiminofuranoses, a new class ofa-glucosidase inhibitors.

BindingDB (2016) · UC San Diego · doi:10.7270/q2t43vrs

Iminosugars: Therapeutic Applications and Synthetic Considerations

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Iminosugars

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Recent synthetic strategies to access diverse iminosugars

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The synthesis and biology of iminosugars and their precursors

Ayers, B. J., & Ayers, B. (2014) · Oxford University Research Archive (ORA) (University of Oxford) · doi:10.5287/ora-eqedyk11r

Iminosugars past, present and future: Medicines for tomorrow

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