Immune and Neuroimmune Alterations in Mood Disorders and Schizophrenia
Abstract
A large number of publications over the past 20 years have indicated that immune system function is altered in schizophrenia and mood disorder patients. This chapter reviews the evidence, which suggests that a proinflammatory state of the cytokine network induces psychopathologic symptoms and may be involved in the pathogenesis and pathophysiology of these major mental illnesses. The authors also present recent data, which relates immune activation to present theories on the influence of activated immune cells in altering brain function. They also focus on the role of the environment in immune activation and on the role of the microbiome and gut flora. Increased understanding of such factors could help in the development of novel treatment strategies and improved clinical management of mental disorders.
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In previous studies, lymphocyte number has been found to be reduced or similar in BD patients compared to healthy subjects.
“In previous studies, the lymphocyte number has been found to be reduced or similar in BD patients compared to healthy subjects [17,44,45].”
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References 120 · Cited by 71
- Authors
- Drexhage, R. C., Weigelt, K., van Beveren, N., Cohen, D., Versnel, M. A., Nolen, W. A., & Drexhage, H. A.
- Affiliations
- Erasmus MC (NL)
- University Medical Center Groningen (NL)
- Venue
- International Review of Neurobiology
- Publisher
- Elsevier
- Published
- 2011
- Volume
- 101
- Pages
- 169-201
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W1529651858
- Cited by
- 71
- References
- 120
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 7 · 2012: 2
- FWCI
- 8.20
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuroimmunology, schizophrenia, mood disorders, inflammatory cytokines, immune activation, psychopathology, environmental factors, gut microbiota
- MeSH terms
- Humans, Immunity, Innate, Inflammation, Schizophrenia, Neuroimmunomodulation, Mood Disorders, Adaptive Immunity
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