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Human iPSC Models in Drug Discovery: Opportunities and Challenges
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Human stem cell-derived neurons allow access to physiologically relevant cell types and protein complexes, offering the advantage of modeling pathogenic tau species without the need for overexpression of heterologous genes, in the context of the patient genomic background.
“Human stem cell-derived neurons allow access to physiologically relevant cell types and protein complexes, offering the advantage of modeling pathogenic tau species without the need for overexpression of heterologous genes, in the context of the patient genomic background”
From Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models (2019) · cites this paper as Silva et al., 2017
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References 257 · Cited by 6
Research works printed but not linked: 2
- Mattis, 2015, Modeling Huntingtons Disease With Patient-Derived Neurons, Brain Res.
- Martinez, R.; Hsu, S.; Ezerskiy, L. A.; Shu, H. J.; Mennerick, S.; Goate, A. M.; Karch, C. M. Efficient Production, Banking and Terminal Differentiation of Neural Progenitor Cells From Human Induced Pluripotent Stem Cells. (in press).
Metadata
- Authors
- Silva, M. C., Cross, A., Brandon, N. J., & Haggarty, S. J.
- Affiliations
- Harvard University (US)
- AstraZeneca (United States) (US)
- Venue
- Comprehensive Medicinal Chemistry III
- Publisher
- Elsevier
- Published
- 2017
- Pages
- 48-73
- OpenAlex
- W2551793832
- Cited by
- 6
- References
- 257
- Citations by year
- 2024: 1 · 2022: 1 · 2020: 1 · 2019: 2 · 2017: 1
- FWCI
- 1.23
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Elsevier eBooks (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › CRISPR and Genetic Engineering
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- human induced pluripotent stem cells, iPSC-derived disease models, drug discovery, high-throughput phenotypic screening, CRISPR/Cas9 genome editing, biomarker discovery, central nervous system disorders, organoids, drug toxicity testing, precision medicine, patient stratification, drug response signatures
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