The DOI matches its Crossref record; 84 of the 84 references it cites were found in a registry or an index.
Thermoregulation in Parkinson disease
Abstract
Autonomic dysfunction in Parkinson disease encompasses thermoregulatory symptoms and was first noted by Gowers in the late 19th century when he described abnormal temperature sensation and sweating in Parkinson disease patients. These thermoregulatory symptoms became more recognized in the postlevodopa era when Parkinson disease patients were more readily tested with objective autonomic function tests. Objective thermoregulatory testing in Parkinson disease reveals deficits of sweating and vasomotor tone which often correlate with the severity of other autonomic deficits. Tests of thermoregulatory function can also be used to differentiate Parkinson disease from other neurodegenerative disorders. The pathophysiology of thermoregulatory dysfunction in Parkinson disease encompasses both central and peripheral mechanisms; involvement of the brainstem and hypothalamus with alpha-synuclein pathology is well recognized with increasing evidence of peripheral neuropathy in Parkinson disease that influences thermoregulation. Medications used to treat Parkinson disease also affect thermoregulatory symptoms. Disorders of thermoregulation significantly affect the quality of life for patients and their caregivers and can be severe and even life threatening, such as in the parkinsonism-hyperpyrexia syndrome.
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In the citing paper
“In Parkinson’s, the peripheral temperature trace is likely altered by episodic hyperhidrosis39 particularly in the dysautonomic subtype42.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [39]
In the citing paper
“However, both of these diseases are marked by impaired thermoregulation39,40, linked in Parkinson’s to alpha-synuclein pathology in the CNS40 and in Raynaud’s to sympathetic nervous system and α2C adrenoreceptor dysregulation in the small blood vessels of the digits41.”
From Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank (2023) · cites this paper as [39]
Citations
Cites
1 retracted
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Skin blood flow in adult human thermoregulation: How it works, when it does not, and why
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Evidence that incidental Lewy body disease is pre-symptomatic Parkinson’s disease
Dickson, D. W., Fujishiro, H., DelleDonne, A., Menke, J., Ahmed, Z., Klos, K. J., Josephs, K. A., Frigerio, R., Burnett, M., Parisi, J. E., et al. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0345-7 · Cited by 364
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Skin nerve α-synuclein deposits
Donadio, V. A., Incensi, A., Leta, V., Giannoccaro, M. P., Scaglione, C. L. M., Martinelli, P., Capellari, S., Avoni, P., Baruzzi, A., & Liguori, R. (2014) · Neurology · doi:10.1212/wnl.0000000000000316 · Cited by 301
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Sorted by citations
Diurnal rhythms of wrist temperature are associated with future disease risk in the UK Biobank
Brooks, T. G., Lahens, N. F., Grant, G. R., Sheline, Y. I., FitzGerald, G. A., & Skarke, C. (2023) · Nature Communications · doi:10.1038/s41467-023-40977-5 · Cited by 57
van Wamelen, D. J., Leta, V., Podlewska, A. M., Wan, Y.-M., Krbot, K., Jaakkola, E., Martinez-Martin, P., Rizos, A., Parry, M., Metta, V., et al. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09325-w · Cited by 39
Heart Matters: Cardiac Dysfunction and Other Autonomic Changes in Parkinson’s Disease
Gonçalves, V. C., Cuenca-Bermejo, L., Fernandez-Villalba, E., Martin-Balbuena, S., da Silva Fernandes, M. J., Scorza, C. A., & Herrero, M.-T. (2022) · The Neuroscientist · doi:10.1177/1073858421990000 · Cited by 37
Metadata
- Authors
- Coon, E. A., & Low, P. A.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Elizabeth A. Coon
- Venue
- Handbook of Clinical Neurology
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 157
- Pages
- 715-725
- ISSN
- 0072-9752 (ISSN-L)
- OpenAlex
- W2900983333
- Cited by
- 51
- References
- 84
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 8 · 2023: 8 · 2022: 7 · 2021: 4 · 2020: 7 · 2019: 3
- FWCI
- 11.49
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Handbook of clinical neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
- Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
- Keywords
- Parkinson's disease, thermoregulation, autonomic dysfunction, sweating, vascular tone, alpha-synuclein pathology, peripheral neuropathy, hypothalamus, brainstem, levodopa, quality of life
- MeSH terms
- Body Temperature Regulation, Humans, Parkinson Disease
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