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Cited by 32Thermal Regulation in MedicineThermoregulation and physiological responsesTraumatic Brain Injury and Neurovascular Disturbances

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Thermoregulation in brain injury

Ram Gowda, Matthew Jaffa, Neeraj Badjatia·2018·Handbook of Clinical Neurology
DOI 10.1016/b978-0-444-64074-1.00049-5
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Abstract

Different mechanisms explain thermoregulatory dysfunction following ischemic stroke, hemorrhagic stroke, and traumatic brain injury. Temperature instability following brain injury likely involves hypothalamic injury, pathologic changes in cerebral blood flow, metabolic derangement, and a neurogenic inflammatory response. Although targeted temperature management (TTM) exerts pleiotropic effects, the heterogeneity of brain injury has hindered identification of patient subsets most likely to benefit from TTM. Early optimism about TTM's role in brain injury has been tempered by the failure of successive clinical trials to show improved patient outcomes. However, given the deleterious effects of fever, aggressive fever management is still warranted in the critically ill neurologic patient.

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References 52 · Cited by 32

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Metadata

Authors
Gowda, R., Jaffa, M., & Badjatia, N.
Affiliations
University of Maryland, Baltimore (US)
Corresponding author
Neeraj Badjatia
ORCID
Venue
Handbook of Clinical Neurology
Publisher
Elsevier
Published
2018
Volume
157
Pages
789-797
ISSN
0072-9752 (ISSN-L)
DOI
10.1016/b978-0-444-64074-1.00049-5
OpenAlex
W2901561568
Cited by
32
References
52
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 1
FWCI
9.28
Type
book chapter
Language
en
Open access
closed
Licence
Locations
  • Handbook of clinical neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Thermal Regulation in Medicine
  • Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
  • Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords
thermoregulation, brain injury, ischemic stroke, hemorrhagic stroke, traumatic brain injury, hypothalamic injury, cerebral blood flow, neurogenic inflammation, targeted temperature management, fever management, hypothermia
MeSH terms
Animals, Body Temperature Regulation, Brain Injuries, Humans, Hypothermia, Induced

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