Cited by 71Cancer, Hypoxia, and MetabolismCancer Cells and MetastasisAngiogenesis and VEGF in Cancer

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Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

Lisha Xiang, Gregg L. Semenza·2019·Advances in Cancer Research

DOI 10.1016/bs.acr.2018.11.001

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Abstract

Clinical studies have revealed that breast cancers contain regions of intratumoral hypoxia (reduced oxygen availability), which activates hypoxia-inducible factors (HIFs). The relationship between intratumoral hypoxia, distant metastasis and cancer mortality has been well established. A major mechanism by which intratumoral hypoxia contributes to disease progression is through induction of the breast cancer stem cell (BCSC) phenotype. BCSCs are a small subpopulation of cells with the capability for self-renewal. BCSCs have been implicated in resistance to chemotherapy, disease recurrence, and metastasis. In this review, we will discuss our current understanding of the molecular mechanisms underlying HIF-dependent induction of the BCSC phenotype in response to hypoxia or chemotherapy.

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Quinlan, K. G. R., Nardini, M., Verger, A., Francescato, P., Yaswen, P., Corda, D., Bolognesi, M., & Crossley, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00680-06 · Cited by 102
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Cowger, J. J. M., Zhao, Q., Isovic, M., & Torchia, J. (2006) · Oncogene · doi:10.1038/sj.onc.1210126 · Cited by 101
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Tang, B., Qi, G., Tang, F., Yuan, S., Wang, Z., Liang, X., Li, B., Yu, S., Liu, J., Huang, Q., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3029 · Cited by 89
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Lee, H.-Y., Choi, K. Y., Oh, H., Park, Y.-K., & Park, H. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.2250 · Cited by 86
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Cheloni, G., Tanturli, M., Tusa, I., DeSouza, N. H., Shan, Y., Gozzini, A., Mazurier, F., Rovida, E., Li, S., & Sbarba, P. D. (2017) · Blood · doi:10.1182/blood-2016-10-745588 · Cited by 84
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Cavadas, M. A. S., Mesnieres, M., Crifò, B., Manresa, M. C., Selfridge, A. C., Keogh, C. E., Fábián, Z., Scholz, C. C., Nolan, K. A., Rocha, L. M. A., et al. (2016) · Scientific Reports · doi:10.1038/srep31355 · Cited by 81
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Danielsen, J. M. R., Knudsen, L. M., Dahl, I. M. S., Lodahl, M., & Rasmussen, T. (2007) · British Journal of Haematology · doi:10.1111/j.1365-2141.2007.06729.x · Cited by 81
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Tong, W., Tong, G., & Liu, Y. (2018) · International Journal of Oncology · doi:10.3892/ijo.2018.4417 · Cited by 78
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Cao, Y., Lin, S., Wang, Y., Chin, Y. E., Kang, L., & Mi, J. (2017) · Theranostics · doi:10.7150/thno.18992 · Cited by 76
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Krohn, A., Song, Y., Muehlberg, F. L., Droll, L. H., Beckmann, C., & Alt, E. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.005 · Cited by 75
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Xiang, L., Gilkes, D. M., Hu, H., Luo, W., Bullen, J. W., Liang, H., & Semenza, G. L. (2015) · Oncotarget · doi:10.18632/oncotarget.4190 · Cited by 73
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Banck, M. S., Li, S., Nishio, H., Wang, C., Beutler, A. S., & Walsh, M. J. (2009) · Epigenetics · doi:10.4161/epi.4.2.7953 · Cited by 72
ZNF217, a candidate breast cancer oncogene amplified at 20q13, regulates expression of the ErbB3 receptor tyrosine kinase in breast cancer cells
Krig, S. R., Miller, J. K., Frietze, S. E., Beckett, L. A., Neve, R. M., Farnham, P., Yaswen, P., & Sweeney, C. A. (2010) · Oncogene · doi:10.1038/onc.2010.289 · Cited by 71
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Hou, P., Li, Y.-H., Lin, S., Lin, S.-C., Lee, J., Lin, B.-W., Liou, J., Chang, J., Kuo, C., Liu, Y.-M., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2990 · Cited by 71
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Newman, B. W., Liu, Y., Lee, H.-F., Sun, D., & Wang, Y. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3600 · Cited by 68
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Behling, K. C., Tang, A., Freydin, B., Chervoneva, I., Kadakia, S., Schwartz, G. F., Rui, H., & Witkiewicz, A. K. (2010) · Breast Cancer Research and Treatment · doi:10.1007/s10549-010-1254-8 · Cited by 23
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Cho, K. H., Yu, S., Cho, D. Y., Park, C. G., & Lee, H. Y. (2015) · BMC Cancer · doi:10.1186/s12885-015-1864-y · Cited by 23
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Guo, L., Zheng, P., Fan, H., Wang, H., Xu, W., & Zhou, W. (2017) · Bioscience Reports · doi:10.1042/bsr20171137 · Cited by 22
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DeCastro, A., Cherukuri, P., Balboni, A., & DiRenzo, J. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0194 · Cited by 20
Histone demethylase JMJD2C: epigenetic regulators in tumors
Zhang, C., Wang, Z., Ji, Q., & Li, Q. (2017) · Oncotarget · doi:10.18632/oncotarget.19176 · Cited by 13
Hypoxia mediated expression of stem cell markers in VHL-associated hemangioblastomas
Ponnaluri, V. K. C., Vavilala, D. T., Prakash, S., & Mukherji, M. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.07.028 · Cited by 10
Addendum: A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages
Lu, H., Clauser, K. R., Tam, W. L., Fröse, J., Ye, X., Eaton, E. N., Reinhardt, F., Donnenberg, V. S., Bhargava, R., Carr, S. A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3281 · Cited by 9

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Authors: Xiang, L., & Semenza, G. L.
Affiliations: Sichuan University (CN)
Johns Hopkins University (US)
Corresponding author: Gregg L. Semenza
ORCID: Lisha Xiang
Gregg L. Semenza
Venue: Advances in Cancer Research
Publisher: Elsevier
Published: 2019
Volume: 141
Pages: 175-212
ISSN: 0065-230X (ISSN-L)
DOI: 10.1016/bs.acr.2018.11.001
OpenAlex: W2904539422
Cited by: 71
References: 256
Citations by year: 2026: 2 · 2025: 8 · 2024: 10 · 2023: 8 · 2022: 12 · 2021: 14 · 2020: 12 · 2019: 5
FWCI: 9.82
Type: book chapter
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Advances in cancer research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: hypoxia-inducible factor, breast cancer stem cells, intratumoral hypoxia, chemoresistance, self-renewal, metastasis, recurrence, HIF signaling
MeSH terms: Animals, Breast Neoplasms, Female, Humans, Neoplastic Stem Cells, Cell Hypoxia, Cell Line, Tumor, Hypoxia-Inducible Factor 1, alpha Subunit

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Hypoxia-inducible factors promote breast cancer stem cell specification and maintenance in response to hypoxia or cytotoxic chemotherapy

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