Gut-to-Brain Axis in Autism Spectrum Disorders
Abstract
Autism spectrum disorders (ASDs) are neurodevelopmental disorders, which occur in early childhood and persist into adulthood. Although the etiology of these disorders is largely unknown, genetic and environmental factors are thought to interplay in the development of ASD. Intestinal microbial dysbiosis, in prenatal and postnatal phases, is an important example of these environmental factors, and gastrointestinal problems including adverse reactions to foods are often reported in these children. In this review, we address the clinical and preclinical findings on the role of the intestinal microbiome in ASD and suggest possible underlying mechanisms. Furthermore, opportunities for (nutritional) interventions in ASD are provided.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysbiosis can decrease the number of amino acids absorbed from the diet and reduce the availability of tryptophan, a precursor for serotonin, creating a vicious cycle.
“On the other hand, dysbiosis can decrease the number of amino acids that are absorbed from the diet and reduce the availability of tryptophan [201], that is a precursor for a number of metabolites as serotonin, thus creating a vicious cycle.”
From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [201]
The citation lists haven’t been fetched yet
References 132 · Cited by 47
- Authors
- Kraneveld, A. D., Szklany, K., de Theije, C. G. M., & Garssen, J.
- Affiliations
- Utrecht University (NL)
- Corresponding author
- Kraneveld, A.D.
- Venue
- International review of neurobiology
- Publisher
- Elsevier
- Published
- 2016
- Volume
- 131
- Pages
- 263-287
- ISSN
- 0074-7742 (ISSN-L)
- OpenAlex
- W2767316205
- Cited by
- 47
- References
- 132
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 7 · 2023: 2 · 2022: 6 · 2021: 6 · 2020: 5 · 2019: 9 · 2017: 7
- FWCI
- 6.58
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- International review of neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, gut-brain axis, gut microbiota, dysbiosis, environmental risk factors, food sensitivity, gastrointestinal symptoms, dietary intervention, neurodevelopmental disorders
- MeSH terms
- Autism Spectrum Disorder, Brain, Humans, Gastrointestinal Tract, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
