Transgenerational epigenetics of traumatic stress
Abstract
Traumatic stress is a type of environmental experience that can modify behavior, cognition and physiological functions such as metabolism, in mammals. Many of the effects of traumatic stress can be transmitted to subsequent generations even when individuals from these generations are not exposed to any traumatic stressor. This book chapter discusses the concept of epigenetic/non-genomic inheritance of such traits involving the germline in mammals. It includes a comprehensive review of animal and human studies on inter- and transgenerational inheritance of the effects of traumatic stress, some of the epigenetic changes in the germline currently known to be associated with traumatic stress, and possible mechanisms for their induction and maintenance during development and adulthood. We also describe some experimental interventions that attempted to prevent the transmission of these effects, and consider the evolutionary importance of transgenerational inheritance and future outlook of the field.
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It has yet to be conclusively established if and how stress-induced epigenetic alterations can be passed on to subsequent generations.
“it has yet to be conclusively established ifand how -stress-induced epigenetic alterations can be passed on to subsequent generations (Jawaid, Roszkowski, & Mansuy, 2018;Youssef, Lockwood, Su, Hao, & Rutten, 2018).”
From The applied implications of epigenetics in anxiety, affective and stress-related disorders - A review and synthesis on psychosocial stress, psychotherapy and prevention (2020) · cites this paper as Jawaid, Roszkowski, & Mansuy, 2018
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References 125 · Cited by 134
- Authors
- Jawaid, A., Roszkowski, M., & Mansuy, I. M.
- Affiliations
- University of Zurich (CH)
- Corresponding author
- Mansuy, Isabelle M.
- Venue
- Progress in Molecular Biology and Translational Science
- Publisher
- Elsevier
- Published
- 2018
- Volume
- 158
- Pages
- 273-298
- ISSN
- 1877-1173 (ISSN-L)
- OpenAlex
- W2808079233
- Cited by
- 134
- References
- 125
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 17 · 2023: 41 · 2022: 14 · 2021: 16 · 2020: 14 · 2019: 9 · 2018: 1
- FWCI
- 13.44
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Progress in molecular biology and translational science (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Keywords
- transgenerational epigenetic inheritance, traumatic stress, epigenetic inheritance, intergenerational transmission, epigenetic interventions, mammalian development
- MeSH terms
- Animals, Disease Models, Animal, Germ Cells, Humans, DNA Methylation, Inheritance Patterns, Stress Disorders, Traumatic, Epigenesis, Genetic
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