Coordinate transcriptional regulation of bile acid homeostasis and drug metabolism

Eloranta, Jyrki J., Kullak-Ublick, Gerd A.·2005·Archives of Biochemistry and Biophysics

Cited by (263)

Items 101–200 of 263

  1. Augmented particle trapping and attenuated inflammation in the liver by protective vaccination against Plasmodium chabaudi malaria
    Jürgen Krücken, Denis Delić, Heike Pauen, Anna Wojtalla, Manal F. El‐Khadragy, Mohamed A. Dkhil, Horst Mossmann, Frank Thomas Wunderlich · 2009 · Malaria Journal
  2. Circadian Rhythms in Liver Physiology and Liver Diseases
    Xin Tong, Lei Yin · 2013 · Comprehensive physiology
  3. Design, synthesis, and evaluation of non-steroidal farnesoid X receptor (FXR) antagonist
    Masahiko Kainuma, Makoto Makishima, Yuichi Hashimoto, Hiroyuki Miyachi · 2007 · Bioorganic & Medicinal Chemistry
  4. Bile Acids, Nuclear Receptors and Cytochrome P450
    Jan Juřica, Gabriela Dovrtělová, Kristýna Nosková, Ondřej Zendulka · 2016 · Physiological Research
  5. Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation
    Gao, Yue, Fan, Shicheng, Li, Hua, Jiang, Yiming, Yao, Xinpeng, Zhu, Shuguang, Yang, Xiao, Wang, Ruimin, Tian, Jianing, Gonzalez, Frank J. et al. · 2021 · Acta Pharmaceutica Sinica B
  6. Mitochondrial genome depletion dysregulates bile acid‐ and paracetamol‐induced expression of the transporters Mdr1, Mrp1 and Mrp4 in liver cells
    María J. Perez, Ester Gonzalez‐Sanchez, Alejandra González‐Loyola, José M. González-Buitrago, JJG Marin · 2010 · British Journal of Pharmacology
  7. Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: Role of the farnesoid X receptor
    Gabriele Campana, Patrizia Pasini, Aldo Roda, Santi Mario Spampinato · 2005 · Biochemical Pharmacology
  8. Differential regulation of constitutive androstane receptor expression by hepatocyte nuclear factor4α isoforms†
    Jean‐Marc Pascussi, Agnès Robert, A Moreau, Jeanne Ramos, Paulette Bioulac‐Sage, Francis Navarro, Pierre Blanc, Eric Assénat, Patrick Maurel, Marie‐José Vilarem · 2007 · Hepatology
  9. Constitutive androstane receptor (CAR) is a xenosensor and target for therapy
    Ekaterina Kachaylo, Vladimir O. Pustylnyak, V. V. Lyakhovich, Lyudmila F Gulyaeva · 2011 · Biochemistry (Moscow)
  10. Conversion of chenodeoxycholic acid to cholic acid by human CYP8B1
    Linbing Fan, Jan Felix Joseph, Pradeepraj Durairaj, Maria Kristina Parr, Matthias Bureik · 2018 · Biological Chemistry
  11. Novel ι-Carrageenan Tetrasaccharide Alleviates Liver Lipid Accumulation via the Bile Acid–FXR–SHP/PXR Pathway to Regulate Cholesterol Conversion and Fatty Acid Metabolism in Insulin-Resistant Mice
    Yanqi Li, Yingying Tian, Weizhen Cai, Qinghui Wang, Yaoguang Chang, Y. Sun, Ping Dong, Jingfeng Wang · 2021 · Journal of Agricultural and Food Chemistry
  12. Pharmacogenetics of Drug Transporters in the Enterohepatic Circulation
    Bruno Stieger, Peter J. Meier · 2011 · Pharmacogenomics
  13. Chenodeoxycholic Acid-mediated Activation of the Farnesoid X Receptor Negatively Regulates Hydroxysteroid Sulfotransferase
    Masaaki Miyata, Yoshiki Matsuda, Hiroyuki Tsuchiya, Hirotaka Kitada, Takanori Akase, Miki Shimada, Kiyoshi Nagata, Frank J. Gonzalez, Yasushi Yamazoe · 2006 · Drug Metabolism and Pharmacokinetics
  14. Hepatobiliary transporters in drug-induced cholestasis: a perspective on the current identifying tools
    Manuela de Lima Toccafondo Vieira, Carlos Alberto Tagliati · 2014 · Expert Opinion on Drug Metabolism & Toxicology
  15. Hepatoprotection of auraptene from the peels of citrus fruits against 17α-ethinylestradiol-induced cholestasis in mice by activating farnesoid X receptor
    Junqiao Wang, Ting Fu, Renchao Dong, Changyuan Wang, Kexin Liu, Huijun Sun, Xiaokui Huo, Xiaodong Ma, Xiaobo Yang, Qiang Meng · 2019 · Food & Function
  16. (Far) Outside the box: Genomic approach to acute porphyria
    Stig Thunell · 2006 · Physiological Research
  17. Role of Pituitary Hormones on 17α-Ethinylestradiol-Induced Cholestasis in Rat
    Luis Alberto Henríquez‐Hernández, Amilcar Flores‐Morales, Ruymán Santana‐Farré, Magnus Axelson, Peter Nilsson, Gunnar Norstedt, Leandro Fernández‐Pérez · 2006 · Journal of Pharmacology and Experimental Therapeutics
  18. Molecular bases of the fetal liver–placenta–maternal liver excretory pathway for cholephilic compounds
    José J.G. Marı́n, Rocı́o I.R. Macı́as, Óscar Briz, María J. Perez, Alba G. Blazquez, Marco A. Arrese, Maria Angeles Serrano · 2008 · Liver International
  19. Microarray-based compendium of hepatic gene expression profiles for prototypical ADME gene-inducing compounds in rats and micein vivo
    J. Greg Slatter, Olivia Cheng, Paul D. Cornwell, Andrea de Souza, John C Rockett, Thomas H. Rushmore, Dylan P. Hartley, Raymond Evers, Yudong D. He, Xudong Dai et al. · 2006 · Xenobiotica
  20. Coordinated Regulation of Dimethylarginine Dimethylaminohydrolase-1 and Cationic Amino Acid Transporter-1 by Farnesoid X Receptor in Mouse Liver and Kidney and Its Implication in the Control of Blood Levels of Asymmetric Dimethylarginine
    Jiang Li, Annette Scierka Wilson, Xiang Gao, Ramalinga Kuruba, Youhua Liu, Samuel Mark Poloyac, Bruce R. Pitt, Wen Xie, Song Li · 2009 · Journal of Pharmacology and Experimental Therapeutics
  21. The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4
    Xiaoxia Gao, Cen Xie, Yuanyuan Wang, Yuhong Luo, Tomoki Yagai, Dongxue Sun, Xuemei Qin, Kristopher W. Krausz, Frank J. Gonzalez · 2016 · Biochemical Pharmacology
  22. Expression of HNF4alpha in the human and rat choroid plexus – Implications for drug transport across the blood-cerebrospinal-fluid (CSF) barrier
    Monika Niehof, Jürgen T. Borlak · 2009 · BMC Molecular Biology
  23. Protective effects of SRT1720 via the HNF1α/FXR signalling pathway and anti-inflammatory mechanisms in mice with estrogen-induced cholestatic liver injury
    Linxi Yu, Xiaoxin Liu, Xiaojiaoyang Li, Zihang Yuan, Hang Yang, Luyong Zhang, Zhenzhou Jiang · 2016 · Toxicology Letters
  24. Metabolic Profiling of the Novel Hypoxia-Inducible Factor 2α Inhibitor PT2385 In Vivo and In Vitro
    Cen Xie, Xiaoxia Gao, Dongxue Sun, You-Bo Zhang, Kristopher W. Krausz, Xuemei Qin, Frank J. Gonzalez · 2018 · Drug Metabolism and Disposition
  25. Medical Treatment of Primary Sclerosing Cholangitis: A Role for Novel Bile Acids and other (post-)Transcriptional Modulators?
    Ulrich H. Beuers, Gerd Achim Kullak-Ublick, Thomas Pusl, Erik A. Rauws, Christian Rust · 2008 · Clinical Reviews in Allergy & Immunology
  26. SEURAT-1 liver gold reference compounds: a mechanism-based review
    Paul Jennings, Michael Schwarz, Brigitte Landesmann, Silvia Maggioni, Μαρίνα Γούμενου, David Bower, Martin Oliver Leonard, Jeffrey S. Wiseman · 2014 · Archives of Toxicology
  27. Cytochrome P450 and gene activation—from pharmacology to cholesterol elimination and regression of atherosclerosis
    Pauli V. Luoma · 2008 · European Journal of Clinical Pharmacology
  28. Lipid sensing and lipid sensors
    Elena Scotti, Federica Gilardi, Cristina Godio, Elise Gers, Jelena Krneta, Nico Mitro, Emma De Fabiani, Donatella Caruso, Maurizio Crestani · 2007 · Cellular and Molecular Life Sciences
  29. Compendium of gene expression profiles comprising a baseline model of the human liver drug metabolism transcriptome
    J. Greg Slatter, Ian E. Templeton, John C. Castle, Amit Kulkarni, Thomas H. Rushmore, Karen M. Richards, Yudong D. He, Xudong Dai, Olivia Cheng, Michelle J. Caguyong et al. · 2006 · Xenobiotica
  30. Nuclear hormone receptor-dependent regulation of hepatic transporters and their role in the adaptive response in cholestasis
    Simone H. Stahl, Mark R. Davies, David I. Cook, M. J. Graham · 2008 · Xenobiotica
  31. Oyster (Crassostrea gigas) Polysaccharide Ameliorates High-Fat-Diet-Induced Oxidative Stress and Inflammation in the Liver via the Bile Acid-FXR-AMPKα Pathway.
    Yu-Yang Ma, Xue Liu, De-Fu Liu, Zihao Yin, Xinyi Yang, M. Zeng · 2022 · Journal of Agricultural and Food Chemistry
  32. Cytochrome P450 — physiological key factor against cholesterol accumulation and the atherosclerotic vascular process
    P. Luoma · 2007 · Annals medicus
  33. Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease
    Elena‐Raluca Nicoli, Nada Al Eisa, Celine V. M. Cluzeau, Christopher A. Wassif, James Gray, Kathryn R. Burkert, David Aitchison Smith, Lauren Morris, Stephanie M. Cologna, Cody J. Peer et al. · 2016 · PLoS ONE
  34. Analysis of ileal sodium/bile acid cotransporter and related nuclear receptor genes in a family with multiple cases of idiopathic bile acid malabsorption
    Marco Montagnani · 2006 · World Journal of Gastroenterology
  35. Modulation of sinusoidal and canalicular elimination of bilirubin‐glucuronides by rifampicin and other cholestatic drugs in a sandwich culture of rat hepatocytes
    György Lengyel, Zsuzsa Veres, Regina Tugyi, Laszlo Vereczkey, Tünde Molnár, Hristos Glavinas, Péter Krajcsi, Katalin Jemnitz · 2007 · Hepatology Research
  36. Building a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70
    Yongtao Li, Wenwei Lin, William C. Wright, Sergio C. Chai, Jing Wu, Taosheng Chen · 2021 · Journal of Medicinal Chemistry
  37. Vitamine D : Métabolisme, régulation et maladies associées
    E. Tissandié, Yann Guéguen, Jean‐Marc A. Lobaccaro, J. Aigueperse, Maâmar Souidi · 2006 · médecine/sciences
  38. Clinical Hepatotoxicity. Regulation and Treatment with Inducers of Transport and Cofactors
    Hanns–Ulrich Marschall, Martin Wagner, Gernot Zollner, Michael A Trauner · 2007 · Molecular Pharmaceutics
  39. Knockdown of ATP8B1 expression leads to specific downregulation of the bile acid sensor FXR in HepG2 cells: effect of the FXR agonist GW4064
    Pilar Martínez-Fernández, Loreto Hierro, Paloma Jara, Luis Álvarez · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  40. Gut Microbiota in the Regulation of Intestinal Drug Transporters: Molecular Mechanisms and Pharmacokinetic Implications
    Patryk Rzeczycki, Oliwia Pęciak, Martyna Plust, Marek Droździk · 2025 · International Journal of Molecular Sciences
  41. Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor
    Yuichiro Kanno, Tomofumi Yatsu, Naoya Yamashita, Shuai Zhao, Wei Li, Miyuki Imai, Manami Kashima, Yoshio Inouye, Kiyomitsu Nemoto, Kazuo Koike · 2017 · Phytomedicine
  42. Medium-Chain Fatty Acids Enhanced the Excretion of Fecal Cholesterol and Cholic Acid in C57BL/6J Mice Fed a Cholesterol-Rich Diet
    Qing Xu, Changyong XUE, Zhang Yong, Yinghua Liu, Jin Wang, Xiaoming Yu, Xinsheng Zhang, Rongxin Zhang, Xueyan Yang, Changjiang Guo · 2013 · Bioscience Biotechnology and Biochemistry
  43. Association of genes involved in bile acid synthesis with the progression of primary biliary cirrhosis in Japanese patients
    Tatsuo Inamine, Shingo Higa, Fumie Noguchi, Shinji Kondo, Katsuhisa Omagari, Hiroshi Yatsuhashi, Kazuhiro Tsukamoto, Minoru Nakamura · 2013 · Journal of Gastroenterology
  44. Regulation of the gene encoding the intestinal bile acid transporter ASBT by the caudal-type homeobox proteins CDX1 and CDX2
    Li Ma, Moritz Jüttner, Gerd Achim Kullak-Ublick, Jyrki J. Eloranta · 2011 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  45. Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity
    Masaaki Miyata, Hirotaka Watase, Wataru Hori, Masayuki Shimada, Kiyoshi Nagata, Frank J. Gonzalez, Yasushi Yamazoe · 2006 · Xenobiotica
  46. Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential
    Mélanie Verreault, Jenny Kaeding, Patrick Caron, Jocelyn Trottier, Laurent Grosse, Élise Houssin, Sophie Pâquet, Martin Perreault, Olivier Barbier · 2009 · Drug Metabolism Reviews
  47. Human and Murine Hepatic Sterol-12-α-Hydroxylase and Other Xenobiotic Metabolism mRNA Are Upregulated by Soy Isoflavones
    Yilan Li, Orsolya Mezei, Neil F. Shay · 2007 · Journal of Nutrition
  48. Nuclear Receptor Co-regulators
    David Michael Lonard, Bert W. O’Malley · 2013 · Elsevier eBooks
  49. Gene expression profiling of rat liver reveals a mechanistic basis for ritonavir-induced hyperlipidemia
    Pek Yee Lum, Yudong D. He, J. Greg Slatter, Jeffrey F. Waring, Nicollete Zelinsky, Guy Cavet, Xudong Dai, Olivia Fong, Rebecca J. Gum, Lixia Jin et al. · 2007 · Genomics
  50. Regulation of the human lipoprotein lipase gene by the forkhead box transcription factor FOXA2/HNF-3β in hepatic cells
    Maria Kanaki, Dimitris Kardassis · 2017 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  51. Expression, localization, and inducibility by bile acids of hepatobiliary transporters in the new polarized rat hepatic cell lines, Can 3−1 and Can 10
    Doris Cassio, Rocı́o I.R. Macı́as, Brigitte Grosse, José J.G. Marı́n, María Jesús Monte · 2007 · Cell and Tissue Research
  52. The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors
    Jean‐François Landrier, Charles Thomas, Jacques Grober, Isabelle Zaghini, Valérie Petit, Hélène Poirier, Isabelle Niot, Philippe Besnard · 2005 · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  53. Bile acids inhibit duodenal secretin expression via orphan nuclear receptor small heterodimer partner (SHP)
    Ian P. Y. Lam, Leo T. O. Lee, Hueng-Sik Choi, Gianfranco D. Alpini, Bkc Chow · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  54. Cancer Stem Cells: Emergent Nature of Tumor Emergency
    Yaroslav R. Efremov, Anastasia S. Proskurina, Ekaterina A. Potter, Е. В. Долгова, O. V. Efremova, Oleg Svyatoslavovich Taranov, Aleksandr Ostanin, Elena Removna Chernykh, Nikolay Alexandrovich Kolchanov, Sergey S. Bogachev · 2018 · Frontiers in Genetics
  55. Ameliorative potential of Adhatoda vasica against anti-tubercular drugs induced hepatic impairments in female Wistar rats in relation to oxidative stress and xeno-metabolism
    Varsha Sharma, Rajwinder Kaur, Vijay Lakshmi Sharma · 2020 · Journal of Ethnopharmacology
  56. Bile acid-induced expression of farnesoid X receptor as the basis for superiority of internal biliary drainage in experimental biliary obstruction
    Lili Wu, Wen Li, Zikai Wang, Zuohui Yuan, Qurratulain Hyder · 2013 · Scandinavian Journal of Gastroenterology
  57. Transcriptomic Analysis of Hepatic Cells in Multicellular Organotypic Liver Models
    Allison N. Tegge, Richard Rosario Rodrigues, Adam L. Larkin, Lucas T. Vu, T. M. Murali, Padmavathy Rajagopalan · 2018 · Scientific Reports
  58. Advantages of cell-based high-volume screening assays to assess nuclear receptor activation during drug discovery
    Marija Pinne, Judy L. Raucy · 2014 · Expert Opinion on Drug Discovery
  59. Review article: nuclear receptors and liver disease – current understanding and new therapeutic implications
    Diaa Elfaki, Einar Stefan Bjornsson, Keith D. Lindor · 2009 · Alimentary Pharmacology & Therapeutics
  60. In vitro anti-oxidant and cytotoxic analysis of Pogostemon mollis Benth
    Elizabeth George, Kasipandi Muniyandi, Vekataramana Mudili, Kalagatur Naveen Kumar, Joseph Anthuvan Allen, Parimelazhagan Thangaraj, N. Gopalan · 2016 · Bangladesh Journal of Pharmacology
  61. Importance of detoxifying enzymes in differentiating fibrotic development between SHRSP5/Dmcr and SHRSP rats
    Hisao Naito, Xiaofang Jia, Husna Yetti, Yukie Yanagiba, Hazuki Tamada, Kazuya Kitamori, Yumi Hayashi, Dong Wang, Masashi Kato, Akira Ishii et al. · 2016 · Environmental Health and Preventive Medicine
  62. Some molecular targets for antihyperlipidemic drug research
    Nikhilesh Arya, Mangesh D. Kharjul, Chamanlal J. Shishoo, Vishnu N. Thakare, Kishor S. Jain · 2014 · European Journal of Medicinal Chemistry
  63. Hepatocyte nuclear factor-4α and bile acids regulate human concentrative nucleoside transporter-1 gene expression
    Kerstin Klein, Gerd Achim Kullak-Ublick, Martin Wagner, Michael A Trauner, Jyrki J. Eloranta · 2009 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  64. The many facets of bile acids in the physiology and pathophysiology of the human liver
    Christoph G. W. Gertzen, Holger Gohlke, Dieter Häussinger, Diran Agaid Herebian, Verena Keitel, Ralf Kubitz, Ertan Mayatepek, Lutz Schmitt · 2021 · Biological Chemistry
  65. Upregulation of decorin by FXR in vascular smooth muscle cells
    Fengtian He, Qiuhong Zhang, Ramalinga Kuruba, Xiang Gao, Li Jiang, Yong Li, Wei Gong, Yu Jiang, Wen Xie, Song Li · 2008 · Biochemical and Biophysical Research Communications
  66. Black Raspberry Polyphenols Shape Metabolic Dysregulation and Perturbation in Gut Microbiota to Promote Lipid Metabolism and Liver Regeneration
    Ting Xiao, Feilong Huang, Zhenghong Guo, Xingyan Cheng, Jinchang Duan, Weiyan Dai, Bo Yang, Yi‐Quan Zhang, Ling Tao, Xiangchun Shen · 2025 · Journal of Agricultural and Food Chemistry
  67. Cytosol-nucleus traffic and colocalization with FXR of conjugated bile acids in rat hepatocytes
    María Jesús Monte, Ruben Rosales, Rocı́o I.R. Macı́as, Valeria Iannota, Almudena Martinez‐Fernandez, Marta R. Romero, Alan F. Hofmann, José J.G. Marı́n · 2008 · American Journal of Physiology-Gastrointestinal and Liver Physiology
  68. Mechanism of bile acid-regulated glucose and lipid metabolism in duodenal-jejunal bypass.
    Jie Chai, Lei Zou, Xirui Li, Dali Han, Shan Wang, Sanyuan Hu, Jie Guan · 2015 · PubMed Central
  69. The Biliary System, Second Edition
    David Q.‐H. Wang, Brent A. Neuschwander‐Tetri, Piero Portincasa · 2016 · Colloquium Series on Integrated Systems Physiology From Molecule to Function
  70. 11β-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice
    Carlos A. Penno, Stuart Morgan, Adam J. Rose, Stephan Herzig, Gareth Geoffrey Lavery, Alex Odermatt · 2014 · Molecular Metabolism
  71. A Study on Pharmacokinetics of Bosentan with Systems Modeling, Part 2: Prospectively Predicting Systemic and Liver Exposure in Healthy Subjects
    Rui Li, Emi Kimoto, Mark Niosi, David A. Tess, Jian Lin, Larry M. Tremaine, Li Di · 2018 · Drug Metabolism and Disposition
  72. Advances in predicting CYP-mediated drug interactions in the drug discovery setting
    Jan L. Wahlstrom, Dan A. Rock, J. Greg Slatter, Larry C. Wienkers · 2006 · Expert Opinion on Drug Discovery
  73. Advances in understanding the regulatory mechanism of organic solute transporter α-β
    Zhen-Ning Lu, Hongwei He, Na Zhang · 2022 · Life Sciences
  74. Novel mechanism of transcriptional repression of the human ATP binding cassette transporter A1 gene in hepatic cells by the winged helix/forkhead box transcription factor A2
    Efstathia Thymiakou, Dimitris Kardassis · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
  75. Modulation of gene expression in endothelial cells by hyperlipaemic postprandial serum from healthy volunteers
    Nicolas Dejeans, Jeanette A.M. Maier, Igor Tauveron, Dragan Milenković, Andrzej Mazur · 2010 · Genes & Nutrition
  76. Gene co-expression network analysis identifies porcine genes associated with variation in metabolizing fenbendazole and flunixin meglumine in the liver
    Jeremy Howard, M.S. Ashwell, Ronald E. Baynes, James D. Brooks, James L. Yeatts, Christian Maltecca · 2017 · Scientific Reports
  77. The effect of pancreatic and biliary depletion on the in vivo pharmacokinetics of digoxin in pigs
    Christer Tannergren, Lena Evilevitch, Stefan Grzegorz Pierzynowski, JOSE LUIS VALVERDE PIEDRA, Björn R. Weström, Kennedy Honey Erlwanger, Marcin R. Tatara, Hans Lennernäs · 2006 · European Journal of Pharmaceutical Sciences
  78. FXR Friend-ChIPs in the Enterohepatic System
    Vik Meadows, Zhenning Yang, Veronia Basaly, Grace Liejun Guo · 2023 · Seminars in Liver Disease
  79. Circadian Rhythms in Liver Physiology and Liver Diseases
    Xin Tong, L. Yin · 2013 · Comprehensive Physiology
  80. Mechanistic Exploration of Aristolochic Acid I-Induced Hepatocellular Carcinoma: Insights from Network Toxicology, Machine Learning, Molecular Docking, and Molecular Dynamics Simulation
    Tiantaixi Tu, Tongtong Zheng, Hangqi Lin, Pei-Feng Cheng, Yang Ye, Bolin Liu, Xinwang Ying, Qingfeng Xie · 2025 · Toxins
  81. The Biliary System
    David Q.‐H. Wang, Brent A. Neuschwander‐Tetri, Piero Portincasa · 2012 · Colloquium Series on Integrated Systems Physiology From Molecule to Function
  82. How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion
    José J.G. Marı́n · 2008 · World Journal of Gastroenterology
  83. Tanshinone ⅡA may alleviate rifampin-induced cholestasis by regulating the expression and function of NTCP
    Yujie Yang, Liu Liu, Min Xu, Xi Zhang, Ling Wang, Qiang He, Min Xu, Xian Li Jiang · 2020 · Human & Experimental Toxicology
  84. Farnesoid X Receptor-Mediated Bile Acids Regulation in Cholestasis
    Thamer Abdulla Mohammed, Munaf Hashim Zalzala · 2024 · Indian Journal of Clinical Biochemistry
  85. Molecular mechanisms of transporter regulation and their impairment in intrahepatic cholestasis
    Xiping Li, Yue Xin Zu, Guodong Li, Dong Xiang, Chengliang Zhang, Dong Liu · 2022 · Acta Materia Medica
  86. Organic Cation Transporters
    Thomas Jacob Urban, Kathleen M. Giacomini · 2006
  87. Bile acid profiles and messenger RNA expression of bile acid-related genes in the liver of dairy cows with high versus normal body condition
    Lena Dicks, Katharina Schuh-von Graevenitz, Cornelia P. Prehn, H. Sadri, Morteza Hosseini Ghaffari, Susanne Häussler · 2024 · Journal of Dairy Science
  88. Cold exposure accelerates lysine catabolism to promote cold acclimation via remodeling hepatic histone crotonylation
    Chong Xue, Sijin Zhu, Li Yang, Xiaoming Chen, Liang Lu, Peng Su, Qian Zhang, Xinqin Liu, Ruili Guan, Zongcai Liu et al. · 2024 · Environment International
  89. Down-regulation of bile acid synthesis and a metabolic co-activator under hypoxic conditions – implications in obstructive sleep apnea
    Paul Richard Johnson · 2008 · Medical Hypotheses
  90. Impact of Physiological Determinants: Flow, Binding, Transporters and Enzymes on Organ and Total Body Clearances
    K. Sandy Pang, Huadong Sun, Edwin C.Y. Chow · 2009 · Springer eBooks
  91. Molecular characterization of farnesoid X receptor alpha in Megalobrama amblycephala and its potential roles in high-carbohydrate diet-induced alterations of bile acid metabolism
    Yaping Ge, Wei‐Liang Chen, Miao Sun, Ling Zhang, Wenbin Liu, Xiang‐Fei Li · 2022 · The Journal of Steroid Biochemistry and Molecular Biology
  92. Molecular mechanism for the involvement of nuclear receptor FXR in HBV-associated hepatocellular carcinoma
    Yongdong Niu, Wen Xie, Wenxin Qin · 2011 · Acta Pharmaceutica Sinica B
  93. Metabolism
    Guenther H. Boden, Erez F. Scapa, Keishi Kanno, David E. Cohen, Margaret E. Brosnan, John T. Brosnan, Dominique Pessayre, Namita Roy‐Chowdhury, Yang Lu, Jayanta Roy‐Chowdhury et al. · 2007 · Wiley eBooks
  94. Mechanisms of Bile Formation and Cholestasis
    Saul J. Karpen · 2007 · Cambridge University Press eBooks
  95. Molecular regulation of PGC-1α: from protein-protein interactions and post-translational modifications to pharmacological modulation
    William Q. Rios, Carlos M. Silva, Rita M. Ferreira, José R. B. Gomes · 2026 · Journal of Molecular Medicine
  96. Exploring potential plasma drug targets for cholelithiasis through multiancestry Mendelian randomization
    Xiaoduo Liu, Lubo Shi, Shutian Zhang, Anni Zhou · 2024 · International Journal of Surgery
  97. Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells
    Choy-Hoong Chew, Di-Lin Ng, Shin-Wei Tie, Pei-Chin Ong, Wyi-Sian Lim, Tengku Sifzizul Tengku Muhammad, Quok-Cheong Choo · 2011 · Electronic Journal of Biotechnology
  98. Drug Transporters
    Richard H. Ho, Richard B. Kim · 2009 · Humana Press eBooks
  99. Primary prevention with over-the-counter statins: A cautionary tale
    Frank F. Davidoff · 2005 · Clinical Pharmacology & Therapeutics
  100. Spectral Characterization and Antimicrobial Activity of Chenodeoxycholic Acid Complexes with Zn(II), Mg(II), and Ca(II) Ions
    Abdulrahman Abdulaziz Almehizia, Ahmed Mohamed Naglah, Mohamed Abdulrahman Al-Omar, M. A. Bhat, Fhdah S. Alanazi, Fatimah A. Alotaibi, Asma S. Al‐Wasidi, Moamen Salah El-Deen Refat, Abdel Majid A. Adam · 2023 · Crystals