Peroxynitrite-mediated lipid oxidation and nitration: mechanisms and consequences
Abstract
Lipid oxidation and nitration represents a novel area of research of relevance in the understanding of inflammatory processes. Peroxynitrite, the product of the diffusion-limited reaction between nitric oxide and superoxide anion, mediates oxidative modifications in lipid systems including cell membranes and lipoproteins. In this review, we discuss the mechanisms of lipid oxidation and nitration by peroxynitrite as well as the influence of physiological molecules and cell targets to redirect peroxynitrite reactivity. We also provide evidence to support that oxidation/nitration of lipids results in the formation of novel signaling modulators of key lipid-metabolizing enzymes.
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Fatty acid nitroalkenes are detectable clinically and in rodent models as free, esterified and protein-adducted species.
“Fatty acid nitroalkenes are detectable clinically and in rodent models as free, esterified and protein-adducted species [14], but have not been reported in plants.”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [14]
Fatty acid nitroalkenes have not been reported in plants prior to this study.
“Fatty acid nitroalkenes are detectable clinically and in rodent models as free, esterified and protein-adducted species [14], but have not been reported in plants.”
From Olives and olive oil are sources of electrophilic fatty acid nitroalkenes (2014) · cites this paper as [14]
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References 76 · Cited by 105
- Authors
- Rubbo, H., Trostchansky, A., & O’Donnell, V. B.
- Affiliations
- Universidad de la República de Uruguay (UY)
- University of Wales (GB)
- Corresponding author
- Rubbo, Homero
- O’Donnell, Valerie B.
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 484
- Issue
- 2
- Pages
- 167-172
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2048108632
- Cited by
- 105
- References
- 76
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 1 · 2022: 5 · 2021: 2 · 2020: 7 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 8 · 2015: 7 · 2014: 5 · 2013: 16 · 2012: 7
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- peroxynitrite, lipid oxidation, nitric oxide, superoxide, plasma membrane, lipoproteins, inflammation, lipid-metabolizing enzymes
- MeSH terms
- Carbon Dioxide, Fatty Acids, Lipoxygenase, Nitrates, Nitric Oxide, Oxidation-Reduction, Superoxides, Eicosanoids, Peroxynitrous Acid, Lipid Metabolism, Cyclooxygenase 1
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