CoChat
Sign Up
Cited by 100Ion Transport and Channel RegulationCaveolin-1 and cellular processesAdvancements in Transdermal Drug Delivery

The DOI matches its Crossref record.

Aquaporin-3 in keratinocytes and skin: Its role and interaction with phospholipase D2

Open access
Qin, Haixia, Zheng, Xiangjian, Zhong, Xiaofeng, Shetty, Anita K., Elias, Peter M., Bollag, Wendy B.·2011·Archives of Biochemistry and Biophysics
DOI 10.1016/j.abb.2011.01.014PMC PMC3061340
Open this paper in CoChat — free account

Abstract

Aquaporin 3 (AQP3) is an aquaglyceroporin that transports water and glycerol and is expressed in the epidermis, among other epithelial tissues. We have recently shown that there is an association between this glycerol channel and phospholipase D2 (PLD2) in caveolin-rich membrane microdomains. While PLD2 is able to hydrolyze membrane phospholipids to generate phosphatidic acid, this enzyme also catalyzes, in the presence of primary alcohols, a transphosphatidylation reaction to produce a phosphatidylalcohol. We have proposed that AQP3 associated with PLD2 provides the physiological primary alcohol glycerol to PLD2 for use in the transphosphatidylation reaction to generate phosphatidylglycerol (PG). Further, we have proposed that PG functions as a signaling molecule to mediate early epidermal keratinocyte differentiation, and manipulation of this signaling module inhibits keratinocyte proliferation and enhances differentiation. In contrast, other investigators have suggested a proliferative role for AQP3 in keratinocytes. In addition, AQP3 knockout mice exhibit an epidermal phenotype, characterized by dry skin, decreased elasticity and delayed barrier repair and wound healing, which can be corrected by glycerol but not other humectants. AQP3 levels have also been found to be altered in human skin diseases. In this article the evidence supporting a role for AQP3 in the epidermis will be discussed.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.abb.2011.01.014

Cites

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Aquaporin 3 regulates water transport across the lipid bilayer in keratinocytes and fibroblasts and therefore improves skin health.

    “Aquaporin 3 regulates water transport across the lipid bilayer in keratinocytes and fibroblasts and therefore improves skin health [136]”

    From The Roles of Vitamin C in Skin Health. (2017) · cites this paper as [136]

    The Possible mechanisms section says AQP3 transports water and glycerol in the epidermis and is important to keratinocyte biology and skin function. The paper does not establish this role in fibroblasts. Evidence in vivo also suggests that glycerol transport, rather than water transport alone, accounts for the skin abnormalities observed in AQP3-deficient mice; the claimed water-transport explanation for improved skin health is therefore too specific. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 66

  1. Yamaji, 2006, Cryobiology, 53, 258, 10.1016/j.cryobiol.2006.06.008 · DOI
  2. Verkman, 2000, Am. J. Physiol. Renal Physiol., 278, F13, 10.1152/ajprenal.2000.278.1.F13 · DOI
  3. Borgnia, 1999, Annu. Rev. Biochem., 68, 425, 10.1146/annurev.biochem.68.1.425 · DOI
  4. Ecelbarger, 1995, Am. J. Physiol., 269, F663
  5. Yang, 1997, J. Biol. Chem., 272, 16140, 10.1074/jbc.272.26.16140 · DOI
  6. Echevarria, 1996, J. Biol. Chem., 271, 25079, 10.1074/jbc.271.41.25079 · DOI
  7. Matsuzaki, 1999, J. Histochem. Cytochem., 47, 1275, 10.1177/002215549904701007 · DOI
  8. Sougrat, 2002, J. Invest. Dermatol., 118, 678, 10.1046/j.1523-1747.2002.01710.x · DOI
  9. Yuspa, 1989, J. Cell Biol., 109, 1207, 10.1083/jcb.109.3.1207 · DOI
  10. Menon, 1992, Cell Tissue Res., 270, 503, 10.1007/BF00645052 · DOI
  11. Hennings, 1980, Cell, 19, 245, 10.1016/0092-8674(80)90406-7 · DOI
  12. Menon, 1991, Arch. Dermatol., 127, 57, 10.1001/archderm.1991.01680010067010 · DOI
  13. Menon, 1985, J. Invest. Dermatol., 84, 508, 10.1111/1523-1747.ep12273485 · DOI
  14. Elias, 2002, J. Invest. Dermatol., 119, 1128, 10.1046/j.1523-1747.2002.19512.x · DOI
  15. Pillai, 1991, J. Cell Physiol., 146, 94, 10.1002/jcp.1041460113 · DOI
  16. Oda, 2000, J. Biol. Chem., 275, 1183, 10.1074/jbc.275.2.1183 · DOI
  17. Oda, 1998, J. Biol. Chem., 273, 23344, 10.1074/jbc.273.36.23344 · DOI
  18. Bikle, 1996, J. Clin. Invest., 97, 1085, 10.1172/JCI118501 · DOI
  19. Jaken, 1988, Carcinogenesis, 9, 1033, 10.1093/carcin/9.6.1033 · DOI
  20. Xie, 1999, J. Biol. Chem., 274, 20421, 10.1074/jbc.274.29.20421 · DOI
  21. Tu, 2001, J. Biol. Chem., 276, 41079, 10.1074/jbc.M107122200 · DOI
  22. Zheng, 2003, Biochim. Biophys. Acta, 1643, 25, 10.1016/j.bbamcr.2003.08.006 · DOI
  23. Nemeth-Cahalan, 2000, J. Biol. Chem., 275, 6777, 10.1074/jbc.275.10.6777 · DOI
  24. Bustamante, 2008, J. Am. Soc. Nephrol., 19, 109, 10.1681/ASN.2007010092 · DOI
  25. Zheng, 2003, J. Invest. Dermatol., 121, 1487, 10.1111/j.1523-1747.2003.12614.x · DOI
  26. Boury-Jamot, 2006, Biochim. Biophys. Acta, 1758, 1034, 10.1016/j.bbamem.2006.06.013 · DOI
  27. Gundry, 2009, Mol. Cell Proteomics, 8, 2555, 10.1074/mcp.M900195-MCP200 · DOI
  28. Hendriks, 2004, J. Biol. Chem., 279, 2975, 10.1074/jbc.M310767200 · DOI
  29. Calamita, 2001, Biol. Reprod., 64, 1660, 10.1095/biolreprod64.6.1660 · DOI
  30. Sugiyama, 2001, Biochim. Biophys. Acta, 1522, 82, 10.1016/S0167-4781(01)00320-7 · DOI
  31. Hara-Chikuma, 2008, J. Mol. Med., 86, 221, 10.1007/s00109-007-0272-4 · DOI
  32. Kim, 2010, J. Invest. Dermatol., 130, 2231, 10.1038/jid.2010.99 · DOI
  33. Bollag, 2007, J. Invest. Dermatol., 127, 2823, 10.1038/sj.jid.5700692 · DOI
  34. Calautti, 2005, J. Biol. Chem., 2890, 32856, 10.1074/jbc.M506119200 · DOI
  35. Thrash, 2006, J. Biol. Chem., 281, 12155, 10.1074/jbc.M512116200 · DOI
  36. Ma, 2002, J. Biol. Chem., 277, 17147, 10.1074/jbc.M200925200 · DOI
  37. Hara, 2002, J. Biol. Chem., 277, 46616, 10.1074/jbc.M209003200 · DOI
  38. Hara, 2003, Proc. Natl. Acad. Sci. USA, 100, 7360, 10.1073/pnas.1230416100 · DOI
  39. Goldsmith, 2003, J. Invest. Dermatol., 120, iv, 10.1038/sj.jid.5601788 · DOI
  40. Hara-Chikuma, 2009, Arch. Dermatol. Res., 301, 245, 10.1007/s00403-009-0927-9 · DOI
  41. Fluhr, 2008, Br. J. Dermatol., 159, 23, 10.1111/j.1365-2133.2008.08643.x · DOI
  42. Brisson, 2001, BioEssays, 23, 534, 10.1002/bies.1073 · DOI
  43. Hara-Chikuma, 2008, Mol. Cell Biol., 28, 326, 10.1128/MCB.01482-07 · DOI
  44. Fluhr, 2003, J. Invest. Dermatol., 120, 728, 10.1046/j.1523-1747.2003.12134.x · DOI
  45. Choi, 2005, J. Invest. Dermatol., 125, 288, 10.1111/j.0022-202X.2005.23799.x · DOI
  46. Olsson, 2006, Allergy, 61, 1132, 10.1111/j.1398-9995.2006.01151.x · DOI
  47. K. Nakahigashi, K. Kabashima, A. Ikoma, A.S. Verkman, Y. Miyachi, M. Hara-Chikuma, Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia. J. Invest. Dermatol. E-pub ahead of print (Dec 30, 2010). · DOI
  48. Song, 2008, Int. J. Mol. Med., 22, 229
  49. Liu, 2010, Skin Pharmacol. Physiol., 23, 193, 10.1159/000288166 · DOI
  50. Verkman, 2008, Exp. Dermatol., 17, 871, 10.1111/j.1600-0625.2008.00698.x · DOI
  51. Perkins, 1992, J. Cutaneous Pathol., 19, 476, 10.1111/j.1600-0560.1992.tb01600.x · DOI
  52. Bollag, 2009, J. Invest. Dermatol., 129, 2330, 10.1038/jid.2009.165 · DOI
  53. Hara-Chikuma, 2010, J. Invest. Dermatol., 130, S116a
  54. Mirza, 2007, Br. J. Dermatol., 158, 679, 10.1111/j.1365-2133.2007.08424.x · DOI
  55. Mirza, 2006, J. Invest. Dermatol., 126, 638, 10.1038/sj.jid.5700111 · DOI
  56. Elias, 2005, J. Invest. Dermatol., 125, 183, 10.1111/j.0022-202X.2005.23668.x · DOI
  57. Lingwood, 2010, Science, 327, 46, 10.1126/science.1174621 · DOI · Paper page
  58. Murray, 1998, J. Biol. Chem., 273, 11514, 10.1074/jbc.273.19.11514 · DOI
  59. McMillin, 2002, Biochim. Biophys. Acta, 1585, 97, 10.1016/S1388-1981(02)00329-3 · DOI
  60. Piccotti, 2002, J. Biol. Chem., 277, 12075, 10.1074/jbc.M200029200 · DOI
  61. Lutter, 2000, Nat. Cell Biol., 2, 754, 10.1038/35036395 · DOI
  62. Kuwana, 2002, Cell, 111, 331, 10.1016/S0092-8674(02)01036-X · DOI
  63. Zhai, 2001, BID Eur. J. Biochem., 268, 48, 10.1046/j.1432-1327.2001.01841.x · DOI
  64. Epand, 2002, J. Biol. Chem., 277, 32632, 10.1074/jbc.M202396200 · DOI
  65. Shaban, 2002, Exp. Eye Res., 75, 99, 10.1006/exer.2001.1192 · DOI
  66. Man, 2008, J. Invest. Dermatol., 128, 370, 10.1038/sj.jid.5701011 · DOI

Cited by

Sorted by citations

  • The Roles of Vitamin C in Skin Health.

    Pullar, J., Carr, A., & Vissers, M. (2017) · Nutrients · doi:10.3390/nu9080866 · Cited by 756

    “Aquaporin 3 regulates water transport across the lipid bilayer in keratinocytes and fibroblasts and therefore improves skin health [136]; cyclophilin A and the transmembrane glycoprotein CD147 negatively impact on skin DNA repair mechanisms and affect the inflammatory response, therefore negatively impacting skin heal…”
    Background

Metadata

Authors
Qin, H., Zheng, X., Zhong, X., Shetty, A. K., Elias, P. M., & Bollag, W. B.
Affiliations
  • San Francisco VA Medical Center (US)
  • Charlie Norwood VA Medical Center (US)
Corresponding author
Bollag, Wendy B.
ORCID
Venue
Archives of Biochemistry and Biophysics
Publisher
Elsevier BV
Published
2011-04
Volume
508
Issue
2
Pages
138-143
ISSN
0003-9861 (ISSN-L)
DOI
10.1016/j.abb.2011.01.014
PMC
PMC3061340
OpenAlex
W1978440987
Cited by
100
References
0
Citations by year
2026: 6 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 10 · 2021: 6 · 2020: 12 · 2019: 2 · 2018: 9 · 2017: 11 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2 · 2012: 5
FWCI
0.38
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Archives of Biochemistry and Biophysics (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR045212, AR-45212)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
Keywords
AQP3, phospholipase D2, keratinocytes, epidermis, glycerol transport, transphosphatidylation, keratinocyte differentiation, keratinocyte proliferation, skin barrier repair, wound healing, dry skin, humectants, glycerol channel
MeSH terms
Animals, Humans, Phospholipase D, Protein Binding, Skin, Skin Diseases, Keratinocytes, Aquaporin 3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review