The lncRNA H19 interacts with miR-140 to modulate glioma growth by targeting iASPP
Abstract
H19, one of the first found cancer-associated long non-coding RNAs (lncRNAs), is involved in the development and progression of many types of tumors. An aberrant expression of H19 was observed in hepatocellular carcinoma, cervical cancer, breast cancer, ovarian cancer, and colorectal cancer. However, the exact effects and molecular mechanisms of H19 in glioma progression are still unknown up to now. In this study, we investigated the role of H19 in human glioma cell lines and clinical tumor samples in order to determine the function of this molecule. In our research, lncRNA-H19 was specifically upregulated in glioma cell lines and promoted glioma cell growth through targeting miR-140. Knockdown of H19 inhibited the proliferation and invasion of human glioma cell and suppressed its metastasis in vitro and in vivo. In addition, miR-140 dependent inhibitor of apoptosis-stimulating protein of p53 (iASPP) regulation was required in H19 induced glioma cell growth. These findings indicated that H19 might regulate the tumor growth and metastasis via miR-140 dependent iASPP regulation. Taken together, our data indicated that H19 might be an oncogenic lncRNA that promoted proliferation and metastasis of glioma and could be regarded as a therapeutic target in human glioma.
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Two lncRNAs, H19 and UCA1, regulate glioblastoma progression by interacting with mir-140 and mir-182, respectively.
“Two lncRNAs, H19 and UCA1, regulate GBM progression by interacting with mir-140 and mir-182, respectively.”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [58]
H19 and UCA1 reduce the expression and activity of mir-140 and mir-182, and therefore possess p53-dependent oncogenic activity in glioblastoma.
“H19 and UCA1 reduce the expression and activity of these miRNAs, and therefore possess p53-dependent oncogenic activity in GBM [57,58].”
From The p53 Pathway in Glioblastoma (2018) · cites this paper as [58]
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References 33 · Cited by 86
- Authors
- Zhao, H., Peng, R., Liu, Q., Liu, D., Du, P., Yuan, J., Peng, G., & Liao, Y.
- Affiliations
- Central South University (CN)
- Xinjiang Medical University (CN)
- Corresponding author
- Liao, Yiwei
- Venue
- Archives of Biochemistry and Biophysics
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 610
- Pages
- 1-7
- ISSN
- 0003-9861 (ISSN-L)
- OpenAlex
- W2523765634
- Cited by
- 86
- References
- 33
- Citations by year
- 2025: 2 · 2024: 7 · 2023: 5 · 2022: 3 · 2021: 15 · 2020: 24 · 2019: 10 · 2018: 11 · 2017: 8 · 2016: 1
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of Biochemistry and Biophysics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hunan Provincial Science and Technology Foundation (2015JC3017)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Circular RNAs in diseases
- Keywords
- H19, long non-coding RNA, miR-140, iASPP, glioma, tumor growth, metastasis, cell proliferation, cell invasion, oncogenic lncRNA, therapeutic target
- MeSH terms
- Brain Neoplasms, Glioma, Humans, Neoplasm Metastasis, Repressor Proteins, Gene Expression Regulation, Neoplastic, MicroRNAs, Cell Line, Tumor, Intracellular Signaling Peptides and Proteins, Cell Proliferation, RNA, Long Noncoding
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