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Cited by 10Contact Dermatitis and AllergiesDrug-Induced Adverse ReactionsDermatology and Skin Diseases

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High rate of sensitization to Kathon CG, detected by patch tests in patients with suspected allergic contact dermatitis

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Silva, Eliane Aparecida, Bosco, Marcia Regina Miras, Lozano, Rejane Rojas, Latini, Ana Carla Pereira, Souza, Vânia Nieto Brito de·2020·Anais Brasileiros de Dermatologia
DOI 10.1016/j.abd.2019.09.026PMC PMC7175102
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Abstract

BACKGROUND: Kathon CG, a combination of methylchloroisothiazolinone and methylisothiazolinone, is widely used as preservative in cosmetics, as well in household cleaning products, industrial products such as paints and glues. It has emerged as an important sensitizing agent in allergic contact dermatitis. OBJECTIVES: This study evaluated the reactivity to this substance in patients subjected to patch tests at the Dermatology Institute in Bauru, São Paulo from 2015 to 2017 and its correlation with other preservatives, the professional activity and location of the lesions. METHODS: The patients were submitted to standard series of epicutaneous tests, standardized by the Brazilian Group Studies on Contact Dermatitis. RESULTS: Out the 267 patients tested, 192 presented positivity to at least one substance and 29 of the patients (15.10%) presented reaction to Kathon CG, with predominance of the female gender (n=27); main professional activity associated with Kathon CG sensibilization was cleaning (17.24%), followed by aesthetic areas (13.79%) and health care (10.34%). The most prevalent sensitizations among the substances tested were nickel sulphate (56.3%), followed by cobalt chloride (23.4%), neomycin (18.2%), potassium dichromate (17.7%), thimerosal (14.5%), formaldehyde (13.2%), paraphenylenediamine (9.3%), and fragrance mix (8.3%). STUDY LIMITATIONS: We do not have data from patients that were submitted to patch test a decade ago in order to confront to current data and establish whether or no sensitization to Kathon CG has increased. CONCLUSION: High positivity to Kathon CG corroborates the recent findings in the literature, suggesting more attention to concentration of this substance, used in cosmetics and products for domestic use.

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Figure 1 Location and frequency of lesions in patients with positive tests (percentage).
Figure 1 Location and frequency of lesions in patients with positive tests (percentage).CC BY · PubMed Central
Figure 2 Characteristics of patients with positive results to the Kathon CG (n = 29).
Figure 2 Characteristics of patients with positive results to the Kathon CG (n = 29).CC BY · PubMed Central

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Research works printed but not linked: 23

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  2. Grupo Brasileiro de Estudo em Dermatite de Contato. Estudo multicêntrico para elaboração de uma bateria padrão brasileira de teste de contato. An Bras Dermatol. 2000;75:147–56.
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Cited by

Metadata

Authors
Silva, E. A., Bosco, M. R. M., Lozano, R. R., Latini, A. C. P., & Souza, V. N. B. D.
Affiliations
Instituto Lauro de Souza Lima (BR)
Corresponding author
Silva, Eliane Aparecida
ORCID
Venue
Anais Brasileiros de Dermatologia
Publisher
Elsevier BV
Published
2020-03
Volume
95
Issue
2
Pages
194-199
ISSN
0365-0596 (ISSN-L)
DOI
10.1016/j.abd.2019.09.026
PMC
PMC7175102
OpenAlex
W3003981741
Cited by
10
References
0
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1
FWCI
0.55
Type
journal article
Language
en
Open access
Licence
Locations
  • Anais Brasileiros de Dermatologia (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
  • Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords
Kathon CG, methylchloroisothiazolinone, methylisothiazolinone, allergic contact dermatitis, sensitization, preservatives, patch testing, occupational exposure, cleaning agents, cosmetics, nickel sulfate, thimerosal, formaldehyde, fragrance mix
MeSH terms
Adult, Brazil, Cosmetics, Female, Humans, Male, Middle Aged, Patch Tests, Preservatives, Pharmaceutical, Retrospective Studies, Thiazoles, Logistic Models, Dermatitis, Allergic Contact, Statistics, Nonparametric

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