Self-assembled aliphatic chain extended polyurethane nanobiohybrids: Emerging hemocompatible biomaterials for sustained drug delivery
Abstract
Novel polyurethanes (PUs) have been synthesized using an aliphatic diisocyanate and aliphatic chain extenders with varying chain length. Nanocomposites of PUs have been prepared by dispersing 2-D nanoclay in poly-ol followed by prepolymerization and subsequent chain extension using various chain extenders. Systematic improvement in toughness and adequate enhancement in stiffness in the presence of nanoclay has been observed for PUs with longer chain extenders, and these new classes of nanocomposites exhibit no toughness-stiffness trade-off. Bottom-up self-assembly starting from the molecular level to micron-scale crystallite has been revealed through electronic structure calculation, X-ray diffraction, small-angle neutron scattering, atomic force microscopy and optical images. The role of hydrogen bonding has been revealed for this type of supramolecular assembly, and in the presence of organically modified nanoclay hydrogen bonding contributes to the formation of bigger clusters of nanocomposites. Controlled biodegradation of PU and its nanocomposites has been investigated in enzymatic media. Biocompatibility of these novel nanocomposites has been extensively verified through platelet adhesion, aggregation and hemolysis assay. Sustained drug delivery by biocompatible pristine PU and its nanocomposites has been demonstrated either by controlling the crystallite size of the polyurethane through alteration of the aliphatic chain length of the extender or by incorporating disc-like nanoclay, creating a tortuous path that results in delayed diffusion. Hence, the developed nanohybrids are potential biomaterials for tissue engineering and drug delivery.
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A wide variety of organic, inorganic, polymeric and metallic nanostructures are frequently used as targeted and controlled drug delivery vehicles.
“A wide variety of organic, inorganic, polymeric and metallic nanostructures, including dendrimers, micelles, solid lipid nanoparticles (SLNs), carbon nanotubes, and liposomes, are frequently used as targeted and controlled drug delivery vehicles.3–5”
From Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles (2019) · cites this paper as [5]
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References 55 · Cited by 79
- Authors
- Mishra, A., Singh, S. K., Dash, D., Aswal, V. K., Maiti, B., Misra, M., & Maiti, P.
- Affiliations
- Indian Institute of Technology BHU (IN)
- Institute of Medical Sciences (IN)
- Bhabha Atomic Research Centre (IN)
- Banaras Hindu University (IN)
- University of Guelph (CA)
- Corresponding author
- Maiti, Pralay
- ORCID
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 10
- Issue
- 5
- Pages
- 2133-2146
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2092491813
- Cited by
- 79
- References
- 55
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 16 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 8 · 2018: 9 · 2017: 8 · 2016: 17 · 2015: 3
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Polymer Nanocomposites and Properties
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Materials Science › Biomaterials › Clay minerals and soil interactions
- Keywords
- aliphatic polyurethane, nanoclay, polyurethane nanocomposites, self-assembly, supramolecular self-assembly, hydrogen bonding, chain extenders, enzymatic degradation, hemocompatibility, platelet adhesion, hemolysis, sustained drug release, crystallite size control, tissue engineering biomaterials
- MeSH terms
- Biocompatible Materials, Delayed-Action Preparations, Erythrocyte Membrane, Humans, Materials Testing, Models, Molecular, Polyurethanes, X-Ray Diffraction, Drug Delivery Systems, Spectroscopy, Fourier Transform Infrared, Microscopy, Atomic Force, Neutron Diffraction, Nanocomposites, Scattering, Small Angle, Mechanical Phenomena
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