Electrospun acid-neutralizing fibers for the amelioration of inflammatory response
Open accessAbstract
Biodegradable aliphatic polyesters, especially polylactide (PLA), polyglycolide (PGA), and their copolymer poly(lactide-co-glycolide) (PLGA), are the most representative and widely used synthetic polymers in the field of tissue engineering and regenerative medicine. However, these polyesters often give rise to aseptic inflammation because of their acidic degradation products after implantation. Here, unidirectional shell-core structured fibers of chitosan/poly(lactide-co-glycolide) (i.e., CTS/PLGA) with acid-neutralizing capability were developed for addressing the noted issue by coating the PLGA fiber surfaces with a layer of the alkaline chitosan by coaxial electrospinning. Our results showed that during a period of 8-week degradation, the shell-layer of chitosan with its unique alkaline nature for acid-neutralization obviously hindered the pH decrease as a result of the degradation of PLGA-core. In a mocked acidic environment testing of the human dermal fibroblasts, chitosan-enabled acidity neutralization could significantly reduce in vitro the secretion of inflammatory factors and downregulate the expression of related inflammatory genes. Thereafter, biocompatibility assessment in vitro showed that the CTS/PLGA fibers had poorer cell adhesion capacity than the PLGA fibers but were cytocompatible and promoted cell migration and secretion of collagen. Moreover, subcutaneous embedding for two and four weeks in vivo revealed that the CTS/PLGA fibers significantly reduced the…
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The solution might present the incorporation of basic molecules with the ability to neutralize redundant acidity and maintain pH homeostasis in this biochemical environment.
“The solution might present the incorporation of basic molecules with the ability to neutralize redundant acidity and maintain pH homeostasis in this biochemical environment [219].”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [219]
Released acidic products, in particular, can enhance the inflammatory response in the affected site, supporting tissue fibrosis rather than regeneration.
“Released acidic products, in particular, can enhance the inflammatory response in the affected site, supporting tissue fibrosis rather than regeneration.”
From Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review (2023) · cites this paper as [219]
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Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review
Vach Agocsova, S., Culenova, M., Birova, I., Omanikova, L., Moncmanova, B., Danisovic, L., Ziaran, S., Bakos, D., & Alexy, P. (2023) · Materials · doi:10.3390/ma16124267 · Cited by 98 · see citing works
- Authors
- Shen, Y., Tu, T., Yi, B., Wang, X., Tang, H., Liu, W., & Zhang, Y.
- Affiliations
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Liu, Wei
- Zhang, Yanzhong
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 97
- Pages
- 200-215
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W2965990594
- Cited by
- 87
- References
- 0
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 11 · 2023: 13 · 2022: 15 · 2021: 13 · 2020: 11 · 2019: 1
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Acta Biomaterialia (publishedVersion)
- SSRN Electronic Journal (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31570969, 31870967, 31771050)
- Fundamental Research Funds for the Central Universities (2232019A3-09)
- Donghua University (CUSF-DH-D-2019065)
- Shanghai Key Laboratory of Tissue Engineering (TE1702)
- National Key Research and Development Program of China (2016YFC1100202, 2016YFC1100203)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Keywords
- sterile inflammation, acidic degradation products, coaxial electrospinning, biodegradable polyesters, foreign body giant cells, dermal fibroblasts, collagen secretion, cytocompatibility, aligned fibers
- MeSH terms
- Animals, Foreign-Body Reaction, Humans, Hydrogen-Ion Concentration, Materials Testing, Coated Materials, Biocompatible, Antimicrobial Cationic Peptides, Chitosan, Rats
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