Injectable, degradable, and mechanically adaptive hydrogel induced by L-serine and allyl-functionalized chitosan with platelet-rich plasma for treating intrauterine adhesions
Abstract
The integration of barrier materials with pharmacological therapy is a promising strategy to treat intrauterine adhesions (IUAs). However, most of these materials are surgically implanted in a fixed shape and incongruence with the natural mechanical properties of the uterus, causing poor adaptability and significant discomfort to the patients. Herein, an injectable, biodegradable, and mechanically adaptive hydrogel loaded with platelet-rich plasma (PRP) is created by L‑serine and allyl functionalized chitosan (ACS) to achieve efficient, comfortable, and minimally invasive treatment of IUAs. L‑serine induces fast gelation and mechanical reinforcement of the hydrogel, while ACS introduces, imparting a good injectability and complaint yet strong feature to the hydrogel. This design enables the hydrogel to adapt to the complex geometry and match the mechanical properties of the uterine. Moreover, the hydrogel exhibits proper degradability, sustained growth factors (GFs) of PRP release ability, and good biocompatibility. Consequently, the hydrogel shows promising therapeutic efficacy by reducing collagen fiber deposition and facilitating endometrium cell proliferation, thereby restoring the fertility function of the uterus in an IUAs model of rats. Accordingly, the combination of L‑serine and ACS-induced hydrogel with such advantages holds great potential for treating IUAs. STATEMENT OF SIGNIFICANCE: This research introduces a breakthrough in the treatment of intrauterine adhesion…
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In a rat model of intrauterine injury/adhesions, the chitosan-PRP hydrogel markedly reduced post-surgical adhesions and fibrosis.
“In a rat model of intrauterine injury/adhesions, the chitosan–PRP hydrogel markedly reduced post-surgical adhesions and fibrosis.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [150]
Fertility was restored in treated rats (evidenced by successful pregnancies in the IUA model), whereas untreated rats remained infertile.
“Importantly, fertility was restored in treated rats (evidenced by successful pregnancies in the IUA model), whereas untreated rats remained infertile.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [150]
No notable toxicity or inflammation was observed with the chitosan-PRP hydrogel, indicating good biocompatibility.
“No notable toxicity or inflammation was observed, indicating good biocompatibility (Figure 8B) [150].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [150]
Treated rats had significantly less collagen scar deposition and increased endometrial cell proliferation, leading to near-normal endometrial architecture.
“Treated rats had significantly less collagen scar deposition and increased endometrial cell proliferation, leading to near-normal endometrial architecture.”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [150]
An injectable, in situ gelling hydrogel using allyl-functionalized chitosan combined with L-serine and loaded with platelet-rich plasma is mechanically adaptive, conforming to the uterus shape, and degrades over time.
“Recently, researchers developed an injectable, in situ gelling hydrogel using allyl-functionalized chitosan (a chemically modified chitosan) combined with L-serine as a trigger and loaded with platelet-rich plasma. This hydrogel is mechanically adaptive, conforming to the uterus shape, and degrades over time [150].”
From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [150]
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Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering
Fazel Anvari-Yazdi, A., Badea, I., & Chen, X. (2025) · Gels · doi:10.3390/gels11060441 · Cited by 20 · see citing works
- Authors
- Lv, H., Xu, R., Xie, X., Liang, Q., Yuan, W., Xia, Y., Ao, X., Tan, S., Zhao, L., Wu, J., & Wang, Y.
- Affiliations
- Sichuan Normal University (CN)
- Sichuan University (CN)
- Corresponding author
- Tan, Shiqiao
- Wang, Yi
- Venue
- Acta Biomaterialia
- Publisher
- Elsevier BV
- Published
- 2024-08
- Volume
- 184
- Pages
- 144-155
- ISSN
- 1742-7061 (ISSN-L)
- OpenAlex
- W4400225139
- Cited by
- 38
- References
- 0
- Citations by year
- 2026: 16 · 2025: 16 · 2024: 6
- FWCI
- 4.43
- Type
- journal article
- Language
- en
- Update notices
- erratum (2025-04-01)
- Open access
- closed
- Locations
- Acta Biomaterialia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (52203013)
- Sichuan Provincial Science and Technology Support Program (2024NSFSC1030)
- Chenzhou Municipal Science and Technology Bureau
- Sichuan Province Department of Science and Technology
- State Key Laboratory of Polymer Materials Engineering
- Sichuan University (sklpme2022-4-09)
- Science and Technology Bureau of Chengdu (2022-YF05-01744-SN)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- intrauterine adhesions, injectable hydrogel, chitosan, L-serine, platelet-rich plasma, growth factor release, biodegradable biomaterials, collagen deposition, endometrial proliferation, fertility restoration, minimally invasive treatment
- MeSH terms
- Tissue Adhesions, Animals, Female, Injections, Serine, Uterine Diseases, Uterus, Rats, Sprague-Dawley, Hydrogels, Chitosan, Rats, Platelet-Rich Plasma
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