Solid lipid nanoparticles for targeted brain drug delivery.
Abstract
The present review discusses the potential use of solid lipid nanoparticles for brain drug targeting purposes. The state of the art on surfactant-coated poly(alkylcyanoacrylate) nanoparticles specifically designed for brain targeting is given by emphasizing the transfer of this technology to solid lipid matrices. The available literature on solid lipid nanoparticles and related carriers for brain drug targeting is revised as well. The potential advantages of the use of solid lipid nanoparticles over polymeric nanoparticles are accounted on the bases of a lower cytotoxicity, higher drug loading capacity, and best production scalability. Solid lipid nanoparticles physicochemical characteristics are also particularly regarded in order to address the critical issues related to the development of suitable brain targeting formulations. A critical consideration on the potential application of such technology as related to the current status of brain drug development is also given.
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Adsorption of a plasmatic protein such as apolipoprotein E onto the SLN surface could facilitate its uptake into the brain mediated by adherence to endothelial cells of the blood-brain barrier.
“Furthermore, the adsorption of a plasmatic protein such as the apolipoprotein E, onto SLNs surface could facilitate its uptake into brain mediated by adherence to the endothelial cells of the BBB”
From Nanotechnology: A Promising Approach for Delivery of Neuroprotective Drugs (2020) · cites this paper as Blasi et al., 2007
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References 233 · Cited by 506
- Authors
- BLASI, P., GIOVAGNOLI, S., SCHOUBBEN, A., RICCI, M., & ROSSI, C.
- Affiliations
- University of Perugia (IT)
- Corresponding author
- BLASI, P
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2007-07-10
- Volume
- 59
- Issue
- 6
- Pages
- 454-477
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2112326782
- Cited by
- 506
- References
- 233
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 36 · 2023: 25 · 2022: 36 · 2021: 42 · 2020: 36 · 2019: 26 · 2018: 25 · 2017: 30 · 2016: 24 · 2015: 26 · 2014: 27 · 2013: 27 · 2012: 37
- FWCI
- 7.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- solid lipid nanoparticles, brain drug delivery, brain targeting, surfactant-coated nanoparticles, drug loading capacity, cytotoxicity, physicochemical properties, drug carriers, neuropharmacology
- MeSH terms
- Animals, Blood-Brain Barrier, Brain, Central Nervous System Agents, Humans, Lipids, Surface-Active Agents, Drug Delivery Systems, Nanoparticles
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