Chronobiological aspects of nutrition, metabolic syndrome and obesity
Abstract
The present review starts from the classical physiological and nutritional studies related with food intake control, digestion, transport and absorption of nutrients. It continues with studies related with the metabolism of adipose tissue, and finish with modern experiments in genetics and molecular biology - all from a fresh, chronobiological point of view. Obesity will be explained as a fault in the circadian system, as pathology associated with "chronodisruption". The main gaps in chronobiological research related to obesity will be also identified and chronobiological-based therapies will be proposed in order to allow the resetting of the circadian rhythm among obese subjects.
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A delayed circadian rhythm in late eaters is associated with lower insulin sensitivity and metabolic changes through hormonal changes leading to overweight and obesity.
“A delayed circadian rhythm in late eaters is also associated with the lower insulin sensitivity (32) and metabolic changes (33) through hormonal changes which leads to be overweight and obesity (34) .”
From Effects of consuming later evening meal<i>v</i>. earlier evening meal on weight loss during a weight loss diet: a randomised clinical trial (2021) · cites this paper as [33]
Peripheral clocks can be entrained by zeitgebers, with dietary intake being a dominant zeitgeber for many of these.
“In turn, peripheral clocks can be entrained by zeitgebers, with dietary intake being a dominant zeitgeber for many of these (46,47) .”
From Meal irregularity and cardiometabolic consequences: results from observational and intervention studies (2016) · cites this paper as [46]
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References 120 · Cited by 177
- Authors
- Garaulet, M., & Madrid, J. A.
- Affiliations
- Universidad de Murcia (ES)
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 62
- Issue
- 9-10
- Pages
- 967-978
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W2046918657
- Cited by
- 177
- References
- 120
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 11 · 2021: 9 · 2020: 10 · 2019: 5 · 2018: 13 · 2017: 15 · 2016: 20 · 2015: 7 · 2014: 18 · 2013: 19 · 2012: 16
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advanced Drug Delivery Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- chronobiology, circadian rhythm, obesity, metabolic syndrome, nutrition, food intake regulation, nutrient digestion and absorption, adipose tissue metabolism, circadian rhythm disruption
- MeSH terms
- Adipose Tissue, Animals, Digestion, Eating, Humans, Molecular Biology, Obesity, Metabolic Syndrome, Circadian Clocks
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