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Cited by 89Dental Implant Techniques and OutcomesBone Tissue Engineering MaterialsSurface Treatment and Coatings

Fit and forget: The future of dental implant therapy via nanotechnology

Open access
Gulati, Karan, Chopra, Divya, Kocak-Oztug, Necla Asli, Verron, Elise·2023·Advanced Drug Delivery Reviews
DOI 10.1016/j.addr.2023.114900
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Abstract

Unlike orthopedic implants, dental implants require the orchestration of both osseointegration at the bone-implant interface and soft-tissue integration at the transmucosal region in a complex oral micro-environment with ubiquitous pathogenic bacteria. This represents a very challenging environment for early acceptance and long-term survival of dental implants, especially in compromised patient conditions, including aged, smoking and diabetic patients. Enabling advanced local therapy from the surface of titanium-based dental implants via novel nano-engineering strategies is emerging. This includes anodized nano-engineered implants eluting growth factors, antibiotics, therapeutic nanoparticles and biopolymers to achieve maximum localized therapeutic action. An important criterion is balancing bioactivity enhancement and therapy (like bactericidal efficacy) without causing cytotoxicity. Critical research gaps still need to be addressed to enable the clinical translation of these therapeutic dental implants. This review informs the latest developments, challenges and future directions in this domain to enable the successful fabrication of clinically-translatable therapeutic dental implants that would allow for long-term success, even in compromised patient conditions.

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  • In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.

    “In vitro mineralization, bonding tests, cell culture, and short-term animal studies suggest that PDA can promote hydroxyapatite nucleation, dentin sealing, cell adhesion, osteogenic differentiation, osseointegration, and surface biofunctionalization.”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [46]

    The Metal ions/nanoparticles releasing nanotubes section reports osteoblast spreading and improved osseointegration for polydopamine-functionalized, Ga/Sr-modified implants, including a rabbit bone-defect study. The Osseo-integration section also describes osteogenic effects of BMP-2-loaded nanotubes coated with polydopamine. Neither passage establishes that polydopamine itself causes all these effects, and our copy does not support the claimed hydroxyapatite nucleation, dentin sealing, or bonding-test evidence. No page numbers were available in the indexed passages. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Peri-implantitis represents one of the leading causes of implant failure and is closely associated with the inability of the transgingival region of implants to establish a stable and effective soft tissue seal.

    “Peri-implantitis represents one of the leading causes of implant failure and is closely associated with the inability of the transgingival region of implants to establish a stable and effective soft tissue seal.46”

    From Polydopamine-Based Biomaterials in Oral Medicine: Applications, Mechanisms, and Translational Challenges (2026) · cites this paper as [46]

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Research works printed but not linked: 36

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Authors
Gulati, K., Chopra, D., Kocak-Oztug, N. A., & Verron, E.
Affiliations
The University of Queensland (AU)
Corresponding author
Gulati, Karan
ORCID
Venue
Advanced Drug Delivery Reviews
Publisher
Elsevier BV
Published
2023-08
Volume
199
Pages
114900
ISSN
0169-409X (ISSN-L)
DOI
10.1016/j.addr.2023.114900
OpenAlex
W4379093382
Cited by
89
References
258
Citations by year
2026: 24 · 2025: 30 · 2024: 24 · 2023: 11
FWCI
4.72
Type
journal article
Language
en
Open access
Licence
Locations
  • Advanced Drug Delivery Reviews (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
Funders
University of Queensland
Topics
  • Health Sciences › Dentistry › Oral Surgery › Dental Implant Techniques and Outcomes
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
Keywords
dental implants, nanotechnology, osseointegration, soft tissue integration, antibiotic elution, nanotherapeutics, biopolymers, local drug delivery, bioactivity (biomaterials), cytotoxicity, compromised patients, smoking, diabetes mellitus, aging, oral microenvironment
MeSH terms
Aged, Bacteria, Dental Implantation, Humans, Surface Properties, Titanium, Dental Implants, Osseointegration, Nanotechnology

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