PA binding of phosphatidylinositol 4-phosphate 5-kinase
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PA can recruit and/or activate PIP5K and can locally influence membrane topology.
“PA can recruit and/or activate specific proteins such as PIP5K [55,56] and, with its cone-shaped geometry, PA can locally influence membrane topology and thus impact in membrane trafficking events [59].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [55]
Conversion of DAG into PA generates a bioactive metabolite with multiple functions.
“In principle, conversion of DAG into PA also generates a bioactive metabolite with multiple functions [54–58].”
From Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane (2020) · cites this paper as [55]
Cited by
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Hagerman, R. J., Berry-Kravis, E., Hazlett, H. C., Bailey, D. B., Moine, H., Kooy, R. F., Tassone, F., Gantois, I., Sonenberg, N., Mandel, J. L., et al. (2017) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2017.65 · Cited by 838 · see citing works
Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane
Katan, M., & Cockcroft, S. (2020) · Essays in Biochemistry · doi:10.1042/ebc20200041 · Cited by 176 · see citing works
Self-citation
- Authors
- Stace, C., Manifava, M., Delon, C., Coadwell, J., Cockcroft, S., & Ktistakis, N. T.
- Affiliations
- Babraham Institute (GB)
- University College London (GB)
- Corresponding author
- Ktistakis, Nicholas T.
- Venue
- Advances in Enzyme Regulation
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 48
- Issue
- 1
- Pages
- 55-72
- ISSN
- 0065-2571 (ISSN-L)
- OpenAlex
- W2022731457
- Cited by
- 30
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 6 · 2018: 1 · 2017: 2 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Advances in Enzyme Regulation (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Keywords
- phosphatidylinositol 4-phosphate 5-kinase, phosphatidylinositol-specific phospholipase C, enzyme structure, autoinhibition, PLC isoforms, cancer, immune disorders, neurodegeneration
- MeSH terms
- Amino Acid Sequence, Animals, Binding Sites, Chlorocebus aethiops, Models, Molecular, Molecular Sequence Data, Phosphatidic Acids, Point Mutation, Phosphotransferases (Alcohol Group Acceptor), COS Cells, Feedback, Physiological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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