The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
The effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation when used before mechanical ventilation compared with conventional oxygen therapy and noninvasive positive pressure ventilation. A systematic review and meta-analysis
Abstract
Background The effects of high flow nasal cannula (HFNC) on adult patients when used before mechanical ventilation (MV) are unclear. We aimed to determine the effectiveness of HFNC when used before MV by comparison to conventional oxygen therapy (COT) and noninvasive positive pressure ventilation (NIPPV).Methods The Pubmed, Embase, Medline, Cochrane Central Register of Controlled Trials (CENTRAL) as well as the Information Sciences Institute (ISI) Web of Science were searched for all the controlled studies that compared HFNC with NIPPV and COT when used before MV in adult patients. The primary outcome was the rate of endotracheal intubation and the secondary outcomes were intensive care unit (ICU) mortality and length of ICU stay (ICU LOS).Results Eight trials with a total of 1084 patients were pooled in our final studies. No significant heterogeneity was found in outcome measures. Compared both with COT and NIPPV, HFNC could reduce both of the rate of endotracheal intubation (OR 0.62, 95% CI 0.38-0.99, P=0.05; OR 0.48, 95% CI 0.31-0.73, P=0.0006) and ICU mortality (OR 0.47, 95% CI 0.24-0.93, P=0.03; OR 0.36, 95% CI 0.20-0.63, P=0.0004). As for the ICU LOS, we did not find any advantage of HFNC over COT or NIPPV.Conclusions When used before MV, HFNC can improve the prognosis of patients compared both with the COT and NIPPV.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“A systematic review and meta-analysis of nine RCTs [2] showed that HFNC reduces intubation compared with conventional oxygen (RR 0.85; 95% CI 0.74–0.99) but does not affect the risk of death or ICU length of stay [412–414].”
From Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 (2021) · cites this paper as [412]
Citations
Cites
Multiple Organ Dysfunction Score
Marshall, J. C., Cook, D. J., Christou, N. V., Bernard, G. R., Sprung, C. L., & Sibbald, W. J. (1995) · Critical Care Medicine · doi:10.1097/00003246-199510000-00007 · Cited by 2,539
High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure
Frat, J.-P., Thille, A. W., Mercat, A., Girault, C., Ragot, S., Perbet, S., Prat, G., Boulain, T., Morawiec, E., Cottereau, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503326 · Cited by 2,342
Weaning from mechanical ventilation
Boles, J.-M., Bion, J., Connors, A. F., Herridge, M. S., Marsh, B. J., Mélot, C., Pearl, R. G., SILVERMAN, H. J., Stanchina, M., Vieillard‐Baron, A., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00010206 · Cited by 2,131
Esteban, A. (2002) · JAMA · doi:10.1001/jama.287.3.345 · Cited by 1,768
Melsen, W. G., Rovers, M. M., Groenwold, R. H. H., Bergmans, D. C. J. J., Camus, C., Bauer, T. T., Hanisch, E. W., Klarin, B., Koeman, M., Krueger, W. A., et al. (2013) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70081-1 · Cited by 856
Research in high flow therapy: Mechanisms of action
Dysart, K., Miller, T. L., Wolfson, M. R., & Shaffer, T. H. (2009) · Respiratory Medicine · doi:10.1016/j.rmed.2009.04.007 · Cited by 748
BTS guideline for emergency oxygen use in adult patients
O’Driscoll, B. R., Howard, L., Davison, A. G., & on behalf of the British Thoracic Society (2008) · Thorax · doi:10.1136/thx.2008.102947 · Cited by 727
Noninvasive Ventilation in Severe Hypoxemic Respiratory Failure
Ferrer, M., Esquinas, A. M., Leon, M. E., González, G., Alarcón, A., & Torres, A. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200301-072oc · Cited by 618
The Decision to Extubate in the Intensive Care Unit
Thille, A. W., Richard, J.-C., & Brochard, L. J. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201208-1523ci · Cited by 596
Early Noninvasive Ventilation Averts Extubation Failure in Patients at Risk
Ferrer, M., Valencia, M., Nicolás, J. M., Bernadich, Ó., Badia, J. R., & Torres, A. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200505-718oc · Cited by 567
Outcomes of extubation failure in medical intensive care unit patients*
Thille, A. W., Harrois, A., Schortgen, F., Brun‐Buisson, C., & Brochard, L. J. (2011) · Critical Care Medicine · doi:10.1097/ccm.0b013e3182282a5a · Cited by 541
Corley, A., Caruana, L. R., Barnett, A. G., Tronstad, O., & Fraser, J. F. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer265 · Cited by 497
Nasal high-flow therapy delivers low level positive airway pressure
Parke, R. L., McGuinness, S., & Eccleston, M. L. (2009) · British Journal of Anaesthesia · doi:10.1093/bja/aep280 · Cited by 492
High flow nasal oxygen generates positive airway pressure in adult volunteers
Groves, N., & Tobin, A. E. (2007) · Australian Critical Care · doi:10.1016/j.aucc.2007.08.001 · Cited by 464
The Effects of Flow on Airway Pressure During Nasal High-Flow Oxygen Therapy
Parke, R. L., Eccleston, M. L., & McGuinness, S. (2011) · Respiratory Care · doi:10.4187/respcare.01106 · Cited by 402
Lee, J. H., Rehder, K. J., Williford, W. L., Cheifetz, I. M., & Turner, D. A. (2012) · Intensive Care Medicine · doi:10.1007/s00134-012-2743-5 · Cited by 390
The Sedation Practice in Intensive Care Evaluation (SPICE) Study Group investigators, Shehabi, Y., Chan, L. L. K., Kadiman, S., Alias, A., Ismail, W. N., Tan, M. A. T. I., Khoo, T. M., Ali, S., Saman, M. A., et al. (2013) · Intensive Care Medicine · doi:10.1007/s00134-013-2830-2 · Cited by 354
Predictors of Successful Extubation in Neurosurgical Patients
Namen, A. M., Ely, E. W., Tatter, S. B., Case, L. D., Lucia, M. A., Smith, A. C., LANDRY, S., WILSON, J. A., Glazier, S. S., Branch, C. L., et al. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.3.2003060 · Cited by 354
Ritchie, J. E., Williams, A. B., Gerard, C. J., & Hockey, H. (2011) · Anaesthesia and Intensive Care · doi:10.1177/0310057x1103900620 · Cited by 346
Use of high-flow nasal cannula oxygenation in ICU adults: a narrative review
Papazian, L., Corley, A., HESS, D. R., Fraser, J. F., Frat, J., Guitton, C., Jaber, S., Maggiore, S. M., Nava, S., Rello, J., et al. (2016) · Intensive Care Medicine · doi:10.1007/s00134-016-4277-8 · Cited by 315
Increased use of noninvasive ventilation in French intensive care units
Demoule, A., Girou, E., Richard, J.-C., Taillé, S., & Brochard, L. J. (2006) · Intensive Care Medicine · doi:10.1007/s00134-006-0229-z · Cited by 290
Incidence, risk factors and outcome of barotrauma in mechanically ventilated patients
Anzueto, A., Frutos–Vivar, F., Esteban, A., Alía, I., Brochard, L. J., Stewart, T. E., Benito, S., Tobin, M. J., Elizalde, J., Pálizas, F., et al. (2004) · Intensive Care Medicine · doi:10.1007/s00134-004-2187-7 · Cited by 272
Risk Factors for and Prediction by Caregivers of Extubation Failure in ICU Patients
Thille, A. W., Boissier, F., Ghezala, H. B., Razazi, K., Dessap, A. M., & Brun‐Buisson, C. (2014) · Critical Care Medicine · doi:10.1097/ccm.0000000000000748 · Cited by 267
Keenan, S., Sinuff, T., Cook, D. J., & Hill, N. S. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000148011.51681.e2 · Cited by 257
High-Flow Oxygen Administration by Nasal Cannula for Adult and Perinatal Patients
Ward, J. J. (2013) · Respiratory Care · doi:10.4187/respcare.01941 · Cited by 247
High‐flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model
Frizzola, M. A., Miller, T. L., Rodríguez, M. E., Zhu, Y., Rojas, J., Hesek, A. M., Stump, A., Shaffer, T. H., & Dysart, K. (2010) · Pediatric Pulmonology · doi:10.1002/ppul.21326 · Cited by 228
Delivered Oxygen Concentrations Using Low-Flow and High-Flow Nasal Cannulas
Wettstein, R. B., Shelledy, D. C., & Peters, J. I. (2005) · Respiratory Care · doi:10.4187/respcare.05500604 · Cited by 222
A European survey of noninvasive ventilation practices
Crimi, C., Noto, A., Princi, P., Esquinas, A. M., & Nava, S. (2010) · European Respiratory Journal · doi:10.1183/09031936.00123509 · Cited by 208
BONE MARROW TRANSPLANTATION IN FIVE CHILDREN WITH SICKLE CELL ANAEMIA
Vermylen, C., Ninane, J., Robles, E. F., & Cornu, G. (1988) · The Lancet · doi:10.1016/s0140-6736(88)92239-8 · Cited by 201
Mechanisms of nasal high flow on ventilation during wakefulness and sleep
Mündel, T., Feng, S., Tatkov, S., & Schneider, H. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01308.2012 · Cited by 176
de Lassence, A., Alberti, C., Azoulay, É., Mière, E. L., Cheval, C., Vincent, F., Cohen, Y., Garrouste-Orgeas, M., Adrie, C., Troché, G., et al. (2002) · Anesthesiology · doi:10.1097/00000542-200207000-00021 · Cited by 172
Jones, P., Kamona, S., Doran, O., Sawtell, F., & WILSHER, M. L. (2015) · Respiratory Care · doi:10.4187/respcare.04252 · Cited by 169
Chanques, G., Riboulet, F., Molinari, N., Carr, J., Jung, B., Prades, A., Galia, F., Futier, E., Constantin, J.-M., & Jaber, S. (2013) · PubMed · Cited by 159
Lemiale, V., Mokart, D., Mayaux, J., Lambert, J., Rabbat, A., Demoule, A., & Azoulay, É. (2015) · Critical Care · doi:10.1186/s13054-015-1097-0 · Cited by 156
What Is Ventilator-Associated Pneumonia and Why Is It Important?
Kollef, M. H. (2005) · Respiratory Care · doi:10.4187/respcare.05500714 · Cited by 154
Use of High-Flow Nasal Cannula for Acute Dyspnea and Hypoxemia in the Emergency Department
Rittayamai, N., Tscheikuna, J., Praphruetkit, N., & Kijpinyochai, S. (2015) · Respiratory Care · doi:10.4187/respcare.03837 · Cited by 148
Schettino, G. D. P. P., Altobelli, N., & Kacmarek, R. M. (2008) · Critical Care Medicine · doi:10.1097/01.ccm.0000300084.67277.90 · Cited by 141
Clinical evidence on high flow oxygen therapy and active humidification in adults
Gotera, C., Lobato, S. D., Pinto, T., & Winck, J. C. (2013) · Revista Portuguesa de Pneumologia · doi:10.1016/j.rppneu.2013.03.005 · Cited by 111
Coudroy, R., Jamet, A., Petua, P., Robert, R., Frat, J., & Thille, A. W. (2016) · Annals of Intensive Care · doi:10.1186/s13613-016-0151-7 · Cited by 111
Monro-Somerville, T., Sim, M. R., Ruddy, J., Vilas, M., & Gillies, M. (2016) · Critical Care Medicine · doi:10.1097/ccm.0000000000002091 · Cited by 108
Bell, N., Hutchinson, C. L., Green, T. C., Rogan, E., Bein, K. J., & Dinh, M. M. Q. (2015) · Emergency Medicine Australasia · doi:10.1111/1742-6723.12490 · Cited by 101
Roca, O., García-de-Acilu, M., Caralt, B., Sacanell, J., & Masclans, J. R. (2014) · Transplantation · doi:10.1097/tp.0000000000000460 · Cited by 101
Role of the respiratory muscles in acute respiratory failure of COPD: lessons from weaning failure
Tobin, M. J., Laghi, F. A., & Brochard, L. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00165.2009 · Cited by 92
Effect of High-Flow Nasal Cannula on Thoraco-Abdominal Synchrony in Adult Critically Ill Patients
Itagaki, T., Okuda, N., Tsunano, Y., Kohata, H., Nakataki, E., Onodera, M., Imanaka, H., & Nishimura, M. (2013) · Respiratory Care · doi:10.4187/respcare.02480 · Cited by 86
Kernick, J., & Magarey, J. (2010) · Australian Critical Care · doi:10.1016/j.aucc.2010.01.001 · Cited by 80
Antonelli, M. M., Conti, G., Bufi, M., Costa, M. G., Lappa, A., Rocco, M., GASPARETTO, A., & Meduri, G. U. (2000) · JAMA · doi:10.1001/jama.283.2.235 · Cited by 75
Uğurlu, A. Ö., Sidhom, S. S., Khodabandeh, A., Ieong, M. H., Mohr, C., Lin, D. Y., Buchwald, I., Bahhady, I., Wengryn, J., Maheshwari, V., et al. (2014) · CHEST Journal · doi:10.1378/chest.13-1707 · Cited by 69
Nagata, K., Morimoto, T., Fujimoto, D., Otoshi, T., Nakagawa, A., Otsuka, K., Seo, R., Atsumi, T., & Tomii, K. (2015) · Respiratory Care · doi:10.4187/respcare.04026 · Cited by 66
Risk factors for mortality in patients admitted to intensive care units with pneumonia
Li, G., Cook, D. J., Thabane, L., Friedrich, J. O., Crozier, T. M. E., Muscedere, J., Granton, J. T., Mehta, S., Reynolds, S., Lópes, R. D., et al. (2016) · Respiratory Research · doi:10.1186/s12931-016-0397-5 · Cited by 66
Léone, M., Bourgoin, A., Giuly, E., Antonini, F., Dubuc, M., Viviand, X., Albanèse, J., & Martin, C. (2002) · Critical Care Medicine · doi:10.1097/00003246-200208000-00011 · Cited by 60
Maitra, S., Som, A., Bhattacharjee, S., Arora, M. K., & Baidya, D. K. (2016) · Journal of Critical Care · doi:10.1016/j.jcrc.2016.05.013 · Cited by 57
Nedel, W. L., Deutschendorf, C., & Filho, É. M. R. (2016) · Respiratory Care · doi:10.4187/respcare.04831 · Cited by 50
Sedation during non-invasive ventilation.
Hilbert, G., Clouzeau, B., Bui, H. N., & Vargas, F. (2012) · PubMed · Cited by 45
Luo, J. F., Wang, M. Z., Zhu, H., Liang, B., Liu, D., Peng, X., Wang, R., Li, C., He, C.-Y., & Liang, Z. (2014) · Respirology · doi:10.1111/resp.12383 · Cited by 35
Self-citationComplications of Noninvasive Ventilation
Hill, N. S. (2000) · Respiratory Care · doi:10.1177/002013240004500503 · Cited by 35
PERFORMANCE OF THE LARGE-RESERVOIR OXYGEN MASK (VENTIMASK)
Jones, H., Turner, S., & Hughes, J. M. B. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91930-5 · Cited by 31
Noninvasive Ventilation Practice in Cardiac Surgery Patients: Insights From a European Survey
Guarracino, F., Cabrini, L., Ferro, B., Landoni, G., Lembo, R., Mucchetti, M., Bocchino, S., Zangrillo, A., & Ambrosino, N. (2013) · Journal of Cardiothoracic and Vascular Anesthesia · doi:10.1053/j.jvca.2013.04.005 · Cited by 18
Noninvasive ventilation for acute lung injury a meta-analysis of randomized controlled trials
Xu, X., Yuan, B., Liang, Q., Hu, J., Shi, Z., Huang, H., Fang, H., Sheng, X., Nie, N., & Yin, X. (2016) · Heart & Lung · doi:10.1016/j.hrtlng.2016.02.005 · Cited by 18
Research works printed but not linked: 2
- Esteban, 2002, Characteristics and outcomes in adult patients receiving mechanical ventilation: a 28-day international study, JAMA, 287, 345, 10.1001/jama.287.3.345 · DOI
- Kollef, 2005, What is ventilator-associated pneumonia and why is it important?, Respir Care, 50, 714
Cited by
Sorted by citations
Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Intensive Care Medicine · doi:10.1007/s00134-021-06506-y · Cited by 5,082
Features, Evaluation and Treatment Coronavirus (COVID-19)
Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, S. C., & Napoli, R. D. (2020) · StatPearls · Cited by 3,351
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock 2021.
Evans, L., Rhodes, A., Alhazzani, W., Antonelli, M., Coopersmith, C. M., French, C., Machado, F. R., Mcintyre, L., Ostermann, M., Prescott, H. C., et al. (2021) · Critical Care Medicine · doi:10.1097/ccm.0000000000005337 · Cited by 2,935
Alhazzani, W., Møller, M. H., Arabi, Y. M., Loeb, M., Gong, M. N., Fan, E., Oczkowski, S., Levy, M. M., Derde, L., Dzierba, A., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06022-5 · Cited by 2,105
Alhazzani, W. A., Møller, M. H., Arabi, Y. M., Loeb, M. B., Gong, M. N., Fan, E., Oczkowski, S. J. W., Levy, M. M., Derde, L. P. G., Dzierba, A. L., et al. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004363 · Cited by 1,578
Metadata
- Authors
- Ni, Y.-N., Luo, J., Yu, H., Liu, D., Liang, B.-M., & Liang, Z.-A.
- Affiliations
- Sichuan University (CN)
- Corresponding author
- Liang, Zong-An
- Venue
- The American Journal of Emergency Medicine
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 36
- Issue
- 2
- Pages
- 226-233
- ISSN
- 0735-6757 (ISSN-L)
- OpenAlex
- W2739506637
- Cited by
- 112
- References
- 58
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 11 · 2022: 16 · 2021: 24 · 2020: 39 · 2019: 6 · 2018: 3
- FWCI
- 2.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Emergency Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sichuan Science and Technology Agency (2014SZ0010)
- National Natural Science Foundation of China (81600057)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Respiratory Support and Mechanisms
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Airway Management and Intubation Techniques
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Neonatal Respiratory Health Research
- Keywords
- high-flow nasal cannula, endotracheal intubation, ICU mortality, ICU length of stay, noninvasive positive pressure ventilation, conventional oxygen therapy, mechanical ventilation, adult patients
- MeSH terms
- Cannula, Clinical Trials as Topic, Critical Care, Humans, Intubation, Intratracheal, Oxygen Inhalation Therapy, Positive-Pressure Respiration, Respiration, Artificial
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
