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Cellular response to chemotherapy and radiation in cervical cancer
Open accessAbstract
Effect of irradiation alone and irradiation after 5-fluorouracil (5-FU), paclitaxel, or cisplatin (CDDP) was investigated in human cervical cell lines (CaSki, ME180, SiHa, and C33A). High-risk human papillomavirus (HPV) (+) CaSki and SiHa cells were the most resistant to CDDP, 5-FU, and radiation treatments. Radiation and CDDP and 5-FU resulted in decreased survival of HPV 16 and 18 (+) cells, whereas addition of paclitaxel to radiation treatments decreased killing. Enhanced killing of ME180 cells containing HPV39 sequences was demonstrated with chemoradiotherapy with all agents. HPV(-) C33A was more sensitive to radiation than the other cell lines, and the addition of chemotherapeutic agents did not result in significant change in cytotoxicity. Expression of survivin was inversely proportional to cell sensitivity to CDDP, 5-FU, and radiation. Constitutive AKT levels are the lowest in cell lines that are the most resistant to CDDP, 5-FU, and radiation. These data provide correlation of response to combined therapeutic modalities with HPV status of cervical cancer and expression of survivin and AKT.
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“After normalizing to BAD protein expression, MMC-most resistant SiHa cells (also radiation-resistant) [20] displayed a significantly higher pBADS99/BAD ratio compared to MMC-sensitive cell lines C-33A.”
From Combining Mitomycin C with inhibition of BAD phosphorylation enhances apoptotic cell death in advanced cervical cancer (2024) · cites this paper as [20]
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Wang, L., Zhang, X., Chen, S., Ye, Q., Basappa, B., Zhu, T., Lobie, P. E., & Pandey, V. (2024) · Translational Oncology · doi:10.1016/j.tranon.2024.102103 · Cited by 8
“After normalizing to BAD protein expression, MMC-most resistant SiHa cells (also radiation-resistant) [20] displayed a significantly higher pBADS99/BAD ratio compared to MMC-sensitive cell lines C-33A.”
Metadata
- Authors
- Saxena, A., Yashar, C., Taylor, D. D., & Gercel-Taylor, C.
- Affiliations
- University of Louisville (US)
- ORCID
- Yashar, Catheryn
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 192
- Issue
- 5
- Pages
- 1399-1403
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2013983690
- Cited by
- 54
- References
- 0
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 4 · 2012: 4
- FWCI
- 5.64
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Endometrial and Cervical Cancer Treatments
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- cervical cancer, chemoradiotherapy, radiosensitivity, 5-fluorouracil, paclitaxel, cisplatin, human papillomavirus, HPV status, HPV16, HPV 18, HPV39, survivin, Akt, cell survival, cervical cancer cell lines, drug resistance
- MeSH terms
- Survivin, Antimetabolites, Antineoplastic, Antineoplastic Agents, Antineoplastic Agents, Phytogenic, Cell Survival, Uterine Cervical Neoplasms, Female, Fluorouracil, Humans, Microtubule-Associated Proteins, Neoplasm Proteins, Proto-Oncogene Proteins, Paclitaxel, Protein Serine-Threonine Kinases, Drug Resistance, Neoplasm, Papillomaviridae, Papillomavirus Infections, Cell Line, Tumor, Inhibitor of Apoptosis Proteins, Proto-Oncogene Proteins c-akt
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- The paper
- Saxena, A., Yashar, C., Taylor, D. D., & Gercel-Taylor, C. (2005). Cellular response to chemotherapy and radiation in cervical cancer. American Journal of Obstetrics and Gynecology. https://doi.org/10.1016/j.ajog.2004.12.045
