The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study
Open accessAbstract
Objective The purpose of this study was to calculate first and second trimester reference ranges and within-woman correlations for TSH, free T4, and thyroid antibodies.Study design TSH, free T4, and thyroid antibodies were measured in paired sera from 9562 women in the FaSTER trial of Down syndrome screening.Results The median first trimester TSH (1.05 mIU/L) is lower than the second (1.23 mIU/L); and 98th centile is higher (4.15 vs 3.77 mIU/L). Within-woman paired TSH correlations are moderately strong (r(2) = 0.64). Among women with first trimester TSH values above the 98th centile, second trimester values are over the 95th centile in 68%. Median first trimester free T4 values (1.10 ng/dL) are higher than second (1.01 ng/dL). Paired free T4 measurements correlate weakly (r(2) = 0.23). Among women with first trimester free T4 values below the 2nd centile, second trimester values are below the 5th centile in 32%. Antibody measurements correlate strongly between trimesters (thyroperoxidase r(2) = 0.79, thyroglobulin r(2) = 0.83).Conclusion TSH and free T4 measurements require gestation-specific reference ranges.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Serum TSH levels may be below the nonpregnant reference range in the first half of a normal-term pregnancy (435,436), and especially so in gestational weeks 9-13, during which a subset of pregnant women may develop a suppressed serum TSH (437-439).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [438]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Haddow, J. E., Palomaki, G. E., Allan, W. C., Williams, J. R., Knight, G. J., Gagnon, J., O'Heir, C. E., Mitchell, M. L., Hermos, R. J., Waisbren, S. E., et al. (1999) · New England Journal of Medicine · doi:10.1056/nejm199908193410801 · Cited by 2,558
Self-citationFirst-Trimester or Second-Trimester Screening, or Both, for Down's Syndrome
Malone, F. D., Canick, J. A., Ball, R. H., Nyberg, D. A., Comstock, C. H., Bukowski, R. K., Berkowitz, R. L., Gross, S. J., Dugoff, L., Craigo, S., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043693 · Cited by 1,073
Self-citationMaternal thyroid deficiency and pregnancy complications: implications for population screening
Allan, W. C., Haddow, J. E., Palomaki, G. E., Williams, J. R., Mitchell, M. L., Hermos, R. J., Faix, J. D., & Klein, R. (2000) · Journal of Medical Screening · doi:10.1136/jms.7.3.127 · Cited by 643
Self-citationWald, N. J., Cuckle, H. S., Brock, J. H., Peto, R., Polani, P. E., & Woodford, F. P. (1977) · PubMed · Cited by 527
Vaidya, B., Anthony, S., Bilous, M., Shields, B. M., Drury, J., Hutchison, S., & Bilous, R. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2006-1748 · Cited by 453
Thyroid autoimmunity and hypothyroidism before and during pregnancy
Poppe, K. G. (2003) · Human Reproduction Update · doi:10.1093/humupd/dmg012 · Cited by 309
Casey, B. M., Dashe, J. S., Spong, C. Y., McIntire, D. D., Leveno, K. J., & Cunningham, F. G. (2007) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000262054.03531.24 · Cited by 260
Soldin, O. P., Tractenberg, R. E., Hollowell, J. G., Jonklaas, J., Janicic, N., & Soldin, S. J. (2004) · Thyroid · doi:10.1089/thy.2004.14.1084 · Cited by 253
Dashe, J. S., Casey, B. M., Wells, C. E., McIntire, D. D., Byrd, E. W., Leveno, K. J., & Cunningham, F. G. (2005) · Obstetrics & Gynecology · doi:10.1097/01.aog.0000175836.41390.73 · Cited by 203
Cited by
Sorted by citations
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
Ross, D. S., Burch, H. B., Cooper, D. S., Greenlee, M. C., Laurberg, P., Maia, A. L., Rivkees, S. A., Samuels, M., Sosa, J. A., Stan, M. N., et al. (2016) · Thyroid® · doi:10.1089/thy.2016.0229 · Cited by 2,938
Alexander, E. K., Pearce, E. N., Brent, G. A., Brown, R. S., Chen, H., Dosiou, C., Grobman, W. A., Laurberg, P., Lazarus, J. H., Mandel, S. J., et al. (2017) · Thyroid® · doi:10.1089/thy.2016.0457 · Cited by 2,731
Thyroid disease in pregnancy: new insights in diagnosis and clinical management
Korevaar, T. I. M., Medici, M., Visser, T. J., & Peeters, R. P. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.93 · Cited by 441
Cooper, D. S., & Laurberg, P. (2013) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(13)70086-x · Cited by 310
Metadata
- Authors
- Lambert-Messerlian, G., McClain, M., Haddow, J. E., Palomaki, G. E., Canick, J. A., Cleary-Goldman, J., Malone, F. D., Porter, T. F., Nyberg, D. A., Bernstein, P., & D'Alton, M. E.
- Affiliations
- Brown University (US)
- Royal College of Surgeons in Ireland (IE)
- Intermountain Healthcare (US)
- Swedish Medical Center (US)
- Albert Einstein College of Medicine (US)
- Corresponding author
- Haddow, James E.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2008-07
- Volume
- 199
- Issue
- 1
- Pages
- 62.e1-62.e6
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC2529146
- OpenAlex
- W2091803917
- Cited by
- 118
- References
- 18
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 5 · 2021: 3 · 2020: 1 · 2019: 5 · 2018: 7 · 2017: 12 · 2016: 9 · 2015: 10 · 2014: 9 · 2013: 8 · 2012: 11
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-09-01)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD038652, R01 HD 38652)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Screening and Diagnostics
- Keywords
- thyroid function in pregnancy, thyroid-stimulating hormone, free thyroxine, thyroid autoantibodies, thyroid peroxidase antibodies, thyroglobulin antibodies, reference values, first trimester, second trimester, Down syndrome screening
- MeSH terms
- Adult, Autoantibodies, Female, Gestational Age, Humans, Pregnancy, Pregnancy Trimester, First, Pregnancy Trimester, Second, Reference Values, Thyrotropin, Thyroxine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
