The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Betamethasone in pregnancy: influence of maternal body weight and multiple gestation on pharmacokinetics
Open accessAbstract
Objective The goals of the study were to estimate the pharmacokinetic parameters of standard dose betamethasone in a large obstetrics population and evaluate the effect of maternal body size and multiple gestation on the pharmacokinetic parameters and their observed variability. Study design This was a prospective pharmacokinetic study. Liquid chromatography mass spectrometry was used to measure betamethasone plasma concentrations. Pharmacokinetic parameters and significant clinical covariates were estimated with mixed effect modeling. Bootstrap analysis confirmed validity of the model. Results Two hundred seventy-four blood samples from 77 patients were obtained. The greatest effect on pharmacokinetic variability was observed with maternal lean body weight (LBW). The relationship between the pharmacokinetic parameters and LBW remained linear over a wide range of maternal body sizes. Multiple gestations did not affect the pharmacokinetic parameters. Conclusion Individualization of betamethasone dosing by maternal LBW reduces variability in drug exposure. Mutiple gestations do not require betamethasone dosing adjustment, because pharmacokinetics are the same as singleton gestations.
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Pharmacokinetic/pharmacodynamic frameworks reduce the incidence of RDS by 19% but rely on invasive inputs and do not account for cumulative neurotoxicity risks.
“pharmacokinetic/pharmacodynamic (PK/PD) frameworks reduce the incidence of RDS by 19% but rely on invasive inputs and do not account for cumulative neurotoxicity risks (12).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [12]
The Background (page unavailable) says antenatal steroid treatment decreases RDS risk, and Methods > Patients describes blood draws used for the pharmacokinetic study. It does not report a 19% reduction, show that PK/PD frameworks reduce RDS, or assess whether such frameworks account for cumulative neurotoxicity risks. (LLM, conf=0.87)
Experimental — accuracy not yet measuredGC optimization models are predominantly static.
“GC optimization models are predominantly static; pharmacokinetic/pharmacodynamic (PK/PD) frameworks reduce the incidence of RDS by 19% but rely on invasive inputs and do not account for cumulative neurotoxicity risks (12).”
From Placenta-pulmonary coupling-guided multimodal AI for fetal lung maturity staging and individualized glucocorticoid therapy (2026) · cites this paper as [12]
The Methods describe one population pharmacokinetic model, and the Discussion describes a standard betamethasone dosing regimen. Neither section assesses glucocorticoid optimization models generally or says that they are predominantly static (searched: static optimization models, PK/PD frameworks, and fixed dosing regimens). (LLM, conf=0.72)
Experimental — accuracy not yet measured
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Research works printed but not linked: 26
- Anderson, 2005, Pregnancy-induced changes in pharmacokinetics: a mechanistic-based approach, Clin Pharmacokinet, 44, 989, 10.2165/00003088-200544100-00001 · DOI
- Hodge, 2007, Alterations in drug disposition during pregnancy: implications for drug therapy, Expert Opin Drug Metab Toxicol, 3, 557, 10.1517/17425255.3.4.557 · DOI
- 2000, Antenatal corticosteroids revisited: repeated courses, NIH Consens Statement Online, 17, 1
- 1994, The effect of corticosteroids for fetal lung maturity on perinatal outcomes, NIH Consensus Statement Online, 12, 1
- Roberts, 2006, Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm labor, Cochrane Database Syst Rev, 3, 1492
- Burkett, 1986, Effect of prenatal dexamethasone administration on prevention of respiratory distress syndrome in twin pregnancies, J Perinatol, 6, 304
- Ballabh, 2002, Pharmacokinetics of betamethasone in twin and singleton pregnancy, Clin Pharmacol Ther, 71, 39, 10.1067/mcp.2002.120250 · DOI
- D'Argenio, 1981, Optimal sampling times for pharmacokinetic experiments, J Pharmacokinet Biopharm, 9, 739, 10.1007/BF01070904 · DOI
- Samtani, 2005, Betamethasone pharmacokinetics after two prodrug formulations in sheep: implications for antenatal corticosteroid use, Drug Metab Dispos, 33, 1124, 10.1124/dmd.105.004309 · DOI
- Petersen, 1983, Pharmacokinetics of betamethasone in healthy adults after intravenous administration, Eur J Clin Pharmacol, 25, 643, 10.1007/BF00542353 · DOI
- Luo, 2005, Resolution, quantification and confirmation of betamethasone and dexamethasone in equine plasma by liquid chromatography/tandem mass spectrometry, Rapid Commun Mass Spectrom, 19, 825, 10.1002/rcm.1851 · DOI
- Janmhasatian, 2005, Quantification of lean bodyweight, Clin Pharmacokinet, 44, 1051, 10.2165/00003088-200544100-00004 · DOI
- DuBois, 1916, Clinical calorimetry: a formula to estimate the approximate surface area if height and weight be known, Arch Intern Med, 17, 863, 10.1001/archinte.1916.00080130010002 · DOI
- Keys, 1972, Indices of relative weight and obesity, J Chronic Dis, 25, 329, 10.1016/0021-9681(72)90027-6 · DOI
- Petersen, 1984, Disposition of betamethasone in parturient women after intramuscular administration, Br J Clin Pharmacol, 18, 383, 10.1111/j.1365-2125.1984.tb02480.x · DOI
- Petersen, 1983, Disposition of betamethasone in parturient women after intravenous administration, Eur J Clin Pharmacol, 25, 803, 10.1007/BF00542524 · DOI
- Rasmussen, 2005, Pharmacokinetic interaction studies of atosiban with labetalol or betamethasone in healthy female volunteers, BJOG, 112, 1492, 10.1111/j.1471-0528.2005.00735.x · DOI
- McCrea, 2003, Effects of the neurokinin1 receptor antagonist aprepitant on the pharmacokinetics of dexamethasone and methylprednisolone, Clin Pharmacol Ther, 74, 17, 10.1016/S0009-9236(03)00066-3 · DOI
- Tracy, 2005, Temporal changes in drug metabolism (CYP1A2, CYP2D6 and CYP3A activity) during pregnancy, Am J Obstet Gynecol, 192, 633, 10.1016/j.ajog.2004.08.030 · DOI
- Gibaldi, 1978, Apparent volumes of distribution and drug binding to plasma proteins and tissues, Eur J Clin Pharmacol, 13, 373, 10.1007/BF00644611 · DOI
- Jobe, 2004, Choice and dose of corticosteroid for antenatal treatments, Am J Obstet Gynecol, 190, 878, 10.1016/j.ajog.2004.01.044 · DOI · Paper page
- Brownfoot, 2008, Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth, Cochrane Database Syst Rev, 4, 10.1002/14651858.CD006764.pub2 · DOI
- Jobe, 2009, Betamethasone dose and formulation for induced lung maturation in fetal sheep, Am J Obstet Gynecol, 201, 611.e1, 10.1016/j.ajog.2009.07.014 · DOI
- Green, 2004, What is the best size descriptor to use for pharmacokinetic studies in the obese?, Br J Clin Pharmacol, 58, 119, 10.1111/j.1365-2125.2004.02157.x · DOI
- Han, 2007, Dosing in obesity: a simple solution to a big problem, Clinl Pharmacolo Ther, 82, 505, 10.1038/sj.clpt.6100381 · DOI
- Anderson, 2008, Mechanism-based concepts of size and maturity in pharmacokinetics, Annu Rev Pharmacol Toxicol, 48, 303, 10.1146/annurev.pharmtox.48.113006.094708 · DOI
Cited by
Sorted by citations
Peffer, M. E., Zhang, J. Y., Umfrey, L., Rudine, A. C., Monaghan, A. P., & DeFranco, D. B. (2015) · Molecular Endocrinology · doi:10.1210/me.2015-1042 · Cited by 30
Ma, B., Ran, J., Pan, T., Yan, F., Yue, Z., Yao, Y., Li, Y., & Nie, F. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1791481
Metadata
- Authors
- Della Torre, M., Hibbard, J. U., Jeong, H., & Fischer, J. H.
- Affiliations
- University of Illinois Chicago (US)
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2010-09
- Volume
- 203
- Issue
- 3
- Pages
- 254.e1-254.e12
- ISSN
- 0002-9378 (ISSN-L)
- PMC
- PMC4326076
- OpenAlex
- W1985926274
- Cited by
- 45
- References
- 1
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 5 · 2013: 2 · 2012: 2
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD065532, K12HD055892)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmaceutical studies and practices
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
- Keywords
- betamethasone, pharmacokinetics, pregnancy, maternal weight, lean body weight, multiple pregnancy, glucocorticoid dosing, drug exposure variability, individualized dosing
- MeSH terms
- Adolescent, Adult, Bayes Theorem, Betamethasone, Body Weight, Chromatography, Liquid, Female, Glucocorticoids, Humans, Middle Aged, Pregnancy, Pregnancy, Multiple, Prospective Studies, Body Mass Index, Area Under Curve, Tandem Mass Spectrometry
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