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Cited by 172Gestational Diabetes Research and ManagementPregnancy and Medication ImpactMaternal and Neonatal Healthcare

The risk of stillbirth and infant death stratified by gestational age in women with gestational diabetes

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Rosenstein, Melissa G., Cheng, Yvonne W., Snowden, Jonathan M., Nicholson, James M., Doss, Amy E., Caughey, Aaron B.·2012·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2012.01.014PMC PMC3403365
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Abstract

Objective We sought to compare the different mortality risks between delivery and expectant management in women with gestational diabetes mellitus (GDM). Study design This is a retrospective cohort study that included singleton pregnancies of women diagnosed with GDM delivering at 36-42 weeks' gestational age in California from 1997 through 2006. A composite mortality rate was developed to estimate the risk of expectant management at each gestational age incorporating the stillbirth risk during the week of continuing pregnancy plus the infant mortality risk at the gestational age 1 week hence. Results In women with GDM, the risk of expectant management is lower than the risk of delivery at 36 weeks (17.4 vs 19.3/10,000), but at 39 weeks, the risk of expectant management exceeds that of delivery (relative risk, 1.8; 95% confidence interval, 1.2-2.6). Conclusion In women with GDM, infant mortality rates at 39 weeks are lower than the overall mortality risk of expectant management for 1 week; absolute risks of stillbirth and infant death are low.

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  • Gestational diabetes is associated with disorders of placental insufficiency, such as hypertension in pregnancy and stillbirth, which could be explained by endothelial dysfunction of women with the metabolic syndrome.

    “Gestational diabetes is also associated with disorders of placental insufficiency, such as hypertension in pregnancy and stillbirth, which could be explained by the endothelial dysfunction of women with the metabolic syndrome (Rosenstein et al., 2012; Yang et al., 2022).”

    From Pregnancy-related maternal physiological adaptations and fetal chemical exposure (2023) · cites this paper as Rosenstein et al., 2012

    The Comment section (page not provided) reports that women with gestational diabetes were more likely to experience stillbirth after 35 weeks. The paper does not establish an association with hypertension in pregnancy or identify placental insufficiency or endothelial dysfunction in metabolic syndrome as an explanation. (LLM, conf=0.88)

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References 31 · Cited by 172

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Authors
Rosenstein, M. G., Cheng, Y. W., Snowden, J. M., Nicholson, J. M., Doss, A. E., & Caughey, A. B.
Affiliations
  • University of California, San Francisco (US)
  • Oregon Health & Science University (US)
  • University of Pennsylvania Health System (US)
Corresponding author
Rosenstein, Melissa G.
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2012-04
Volume
206
Issue
4
Pages
309.e1-309.e7
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2012.01.014
PMC
PMC3403365
OpenAlex
W2103329763
Cited by
172
References
31
Citations by year
2026: 6 · 2025: 10 · 2024: 15 · 2023: 24 · 2022: 16 · 2021: 20 · 2020: 14 · 2019: 9 · 2018: 19 · 2017: 10 · 2016: 7 · 2015: 9 · 2014: 8 · 2013: 4 · 2012: 1
FWCI
8.49
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD01262, K12HD001262)
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Health Sciences › Health Professions › General Health Professions › Maternal and Neonatal Healthcare
Keywords
gestational diabetes mellitus, stillbirth, infant mortality, expectant management, delivery timing, gestational age, singleton pregnancy, perinatal outcomes
MeSH terms
California, Female, Gestational Age, Humans, Infant Mortality, Infant, Newborn, Pregnancy, Retrospective Studies, Risk, Diabetes, Gestational, Stillbirth

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