Factors associated with high-risk HPV positivity in a low-resource setting in sub-Saharan Africa
Abstract
Objective We sought to determine demographic and behavioral factors associated with human papillomavirus (HPV) positivity in a community-based HPV self-collection cervical cancer screening pilot project. Study design HPV self-collected samples were obtained from 199 women aged 30-69 years in the impoverished urban Ugandan community of Kisenyi, during September through November 2011. Demographic and behavioral information was collected. Descriptive statistics and a logistic regression model were used to analyze factors associated with HPV positivity. Results There was overwhelming acceptance of HPV self-collection in this community. High-risk HPV prevalence was found to be 17.6%. Lower levels of formal education (adjusted odds ratio [AOR], 0.40; 95% confidence interval [CI], 0.08-2.03) were associated with higher prevalence of HPV as was use of oral contraception (AOR, 2.01; 95% CI, 0.83-4.90) and human immunodeficiency virus status (AOR, 0.43; 95% CI, 0.14-1.37). Conclusion Screening should be targeted and prioritized for women with lower levels of education, oral contraceptive use, and human immunodeficiency virus positivity as they have the highest HPV prevalence in this low-resource population.
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The HPV positivity prevalence aligns with regional estimates ranging between 5% and 15%.
“The HPV positivity prevalence aligns with regional estimates, ranging between 5% and 15%.2,16, 17, 18, 19, 20, 21”
Our study identifies a high prevalence of hrHPV infection among women aged 26 to 40.
“Our study identifies a high prevalence of hrHPV infection among women aged 26 to 40, aligning with data from other low-resource settings.16”
The high prevalence of hrHPV infection among women aged 26 to 40 aligns with data from other low-resource settings.
“Our study identifies a high prevalence of hrHPV infection among women aged 26 to 40, aligning with data from other low-resource settings.16”
Rural residential area reflects poor socio-economic condition possibly related to lack of access to proper care, which facilitates HPV infection and persistence and increases cancer risk.
“Rural residential area reflects poor socio-economic condition possibly related to lack of access to proper care which facilitates infection and persistence of HPV and an increasing risk of cancer development [41].”
From HPV Genotypes distribution in Indian women with and without cervical carcinoma: Implication for HPV vaccination program in Odisha, Eastern India (2017) · cites this paper as [41]
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References 30 · Cited by 37
- Authors
- Mitchell, S. M., Sekikubo, M., Biryabarema, C., Byamugisha, J. J. K., Steinberg, M., Jeronimo, J., Money, D. M., Christilaw, J., & Ogilvie, G. S.
- Affiliations
- University of British Columbia (CA)
- Mulago Hospital (UG)
- Simon Fraser University (CA)
- B.C. Women's Hospital & Health Centre (CA)
- Corresponding author
- Ogilvie, Gina S.
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 210
- Issue
- 1
- Pages
- 81.e1-81.e7
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W1978616412
- Cited by
- 37
- References
- 30
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 3 · 2014: 4
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of British Columbia
- Topics
- Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Women's cancer prevention and management
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- high-risk HPV, HPV prevalence, HPV self-collection, cervical cancer screening, resource-limited settings, oral contraceptive use, HIV status, educational attainment, risk factors, women's health, Uganda
- MeSH terms
- Adult, Aged, Uterine Cervical Neoplasms, Female, Health Resources, Health Surveys, Humans, Middle Aged, Pilot Projects, Risk Factors, Vaginal Smears, Prevalence, Logistic Models, Africa South of the Sahara, Papillomaviridae, Papillomavirus Infections, Early Detection of Cancer
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