CoChat
Sign Up
Cited by 244Birth, Development, and HealthDiet, Metabolism, and DiseaseGestational Diabetes Research and Management

Maternal obesity and high-fat diet program offspring metabolic syndrome

Open access
Desai, Mina, Jellyman, Juanita K., Han, Guang, Beall, Marie, Lane, Robert H., Ross, Michael G.·2014·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2014.03.025PMC PMC4149836
Open this paper in CoChat — free accountOpen PDF

Abstract

Objective We determined the potential programming effects of maternal obesity and high-fat (HF) diet during pregnancy and/or lactation on offspring metabolic syndrome. Study design A rat model of maternal obesity was created using an HF diet prior to and throughout pregnancy and lactation. At birth, pups were cross-fostered, thereby generating 4 paradigms of maternal diets during pregnancy/lactation: (1) control (Con) diet during pregnancy and lactation (Con/Con), (2) HF during pregnancy and lactation (HF/HF), (3) HF during pregnancy alone (HF/Con), and (4) HF during lactation alone (Con/HF). Results Maternal phenotype during pregnancy and the end of lactation evidenced markedly elevated body fat and plasma corticosterone levels in HF dams. In the offspring, the maternal HF diet during pregnancy alone programmed increased offspring adiposity, although with normal body weight, whereas the maternal HF diet during lactation increased both body weight and adiposity. Metabolic disturbances, particularly that of hyperglycemia, were apparent in all groups exposed to the maternal HF diet (during pregnancy and/or lactation), although differences were apparent in the manifestation of insulin resistant vs insulin-deficient phenotypes. Elevated systolic blood pressure was manifest in all groups, implying that exposure to an obese/HF environment is disadvantageous for offspring health, regardless of pregnancy or lactation periods. Nonetheless, the underlying mechanism may differ because offspring that experienced in utero HF exposure had increased corticosterone levels. Conclusion Maternal obesity/HF diet has a marked impact on offspring body composition and the risk of metabolic syndrome was dependent on the period of exposure during pregnancy and/or lactation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.ajog.2014.03.025

Cites

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • A mismatch between nutritional status in the womb and nutritional status once born can contribute to the development of obesity and metabolic disease.

    “While potentially beneficial in times of famine, a mismatch between nutritional status in the womb and nutritional status once born can contribute to the development of obesity and metabolic disease [53,54].”

    From The Pathophysiology of Gestational Diabetes Mellitus (2018) · cites this paper as [54]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The citation lists haven’t been fetched yet

References 46 · Cited by 244

Research works printed but not linked: 41

  1. [1]Ogden CL Carroll MD Kit BK Flegal KM Prevalence of obesity in the United States, 2009–2010 NCHS Data Brief 2012 1 82 1 8 22617494
  2. [2]Fisher SC Kim SY Sharma AJ Rochat R Morrow B Is obesity still increasing among pregnant women? Prepregnancy obesity trends in 20 states, 2003–2009 Prev Med 2013 6 56 6 372 8 23454595 PMC4424789
  3. [3]Kim SY Dietz PM England L Morrow B Callaghan WM Trends in pre-pregnancy obesity in nine states, 1993–2003 Obesity (Silver Spring) 2007 4 15 4 986 93 17426334
  4. [4]Lu GC Rouse DJ DuBard M Cliver S Kimberlin D Hauth JC The effect of the increasing prevalence of maternal obesity on perinatal morbidity Am J Obstet Gynecol 2001 10 185 4 845 9 11641663
  5. [5]Siega-Riz AM Siega-Riz AM Laraia B The implications of maternal overweight and obesity on the course of pregnancy and birth outcomes Matern Child Health J 2006 9 10 5 Suppl S153 6 16927160 PMC1592146
  6. [6]Hales CN Barker DJ The thrifty phenotype hypothesis Br Med Bull 2001 60 5 20 11809615
  7. [8]Hull HR Thornton JC Ji Y Higher infant body fat with excessive gestational weight gain in overweight women Am J Obstet Gynecol 2011 9 205 3 211. e1 7 21621185 PMC3170486
  8. [9]Schack-Nielsen L Michaelsen KF Gamborg M Mortensen EL Sørensen TI Gestational weight gain in relation to offspring body mass index and obesity from infancy through adulthood Int J Obes (Lond) 2010 1 34 1 67 74 19918246
  9. [10]Li M Sloboda DM Vickers MH Maternal obesity and developmental programming of metabolic disorders in offspring: evidence from animal models Exp Diabetes Res 2011 2011 592408 21969822 PMC3182397
  10. [11]Chen H Simar D Morris MJ Hypothalamic neuroendocrine circuitry is programmed by maternal obesity: interaction with postnatal nutritional environment PLoS One 2009 7 16 4 7 e6259 19606226 PMC2707610
  11. [12]Gupta A Srinivasan M Thamadilok S Patel MS Hypothalamic alterations in fetuses of high fat diet-fed obese female rats J Endocrinol 2009 3 200 3 293 300 19074472
  12. [13]Ip S Chung M Raman G Breastfeeding and maternal and infant health outcomes in developed countries Evid Rep Technol Assess (Full Rep) 2007 4 153 1 186 PMC4781366 17764214
  13. [14]Dewey KG Is breastfeeding protective against child obesity? J Hum Lact 2003 2 19 1 9 18 12587638
  14. [15]Rolls BA Gurr MI van Duijvenvoorde PM Rolls BJ Rowe EA Lactation in lean and obese rats: effect of cafeteria feeding and of dietary obesity on milk composition Physiol Behav 1986 38 2 185 90 3797485
  15. [16]Thangaratinam S Rogozińska E Jolly K Interventions to reduce or prevent obesity in pregnant women: a systematic review Health Technol Assess 2012 7 16 31 iii iv 1 191 22814301 PMC4781281
  16. [17]Rasmussen KM Abrams B Bodnar LM Butte NF Catalano PM Maria Siega-Riz A Recommendations for weight gain during pregnancy in the context of the obesity epidemic Obstet Gynecol 2010 11 116 5 1191 5 20966705 PMC4288953
  17. [18]Vesco KK Karanja N King JC Healthy Moms, a randomized trial to promote and evaluate weight maintenance among obese pregnant women: study design and rationale Contemp Clin Trials 2012 7 33 4 777 85 22465256 PMC3361519
  18. [19]Salameh WA Mastrogiannis DS Maternal hyperlipidemia in pregnancy Clin Obstet Gynecol 1994 3 37 1 66 77 8194217
  19. [20]Herrera E Lipid metabolism in pregnancy and its consequences in the fetus and newborn Endocrine 2002 10 19 1 43 55 12583601
  20. [21]Ramsay JE Ferrell WR Crawford L Wallace AM Greer IA Sattar N Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways J Clin Endocrinol Metab 2002 9 87 9 4231 7 12213876
  21. [22]Heerwagen MJ Miller MR Barbour LA Friedman JE Maternal obesity and fetal metabolic programming: a fertile epigenetic soil Am J Physiol Regul Integr Comp Physiol 2010 9 299 3 R711 22 20631295 PMC2944425
  22. [23]Catalano PM Roman-Drago NM Amini SB Sims EA Longitudinal changes in body composition and energy balance in lean women with normal and abnormal glucose tolerance during pregnancy Am J Obstet Gynecol 1998 7 179 1 156 65 9704782
  23. [24]Palinski W Yamashita T Freigang S Napoli C Developmental programming: maternal hypercholesterolemia and immunity influence susceptibility to atherosclerosis Nutr Rev 2007 12 65 12 Pt 2 S182 7 18240546
  24. [25]Napoli C D’Armiento FP Mancini FP Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions J Clin Invest 1997 12 1 100 11 2680 90 9389731 PMC508471
  25. [26]Rodriguez JS Rodríguez-González GL Reyes-Castro LA Maternal obesity in the rat programs male offspring exploratory, learning and motivation behavior: prevention by dietary intervention pre-gestation or in gestation Int J Dev Neurosci 2012 4 30 2 75 81 22239918
  26. [27]Vickers MH Breier BH McCarthy D Gluckman PD Sedentary behavior during postnatal life is determined by the prenatal environment and exacerbated by postnatal hypercaloric nutrition Am J Physiol Regul Integr Comp Physiol 2003 7 285 1 R271 3 12794001
  27. [28]Gardner DS Rhodes P Developmental origins of obesity: programming of food intake or physical activity? Adv Exp Med Biol 2009 646 83 93 10.1007/978-1-4020-9173-5_9 19536666 PMC2701542 · DOI
  28. [29]Donovan EL Hernandez CE Matthews LR Periconceptional undernutrition in sheep leads to decreased locomotor activity in a natural environment J DOHaD 2013 4 296 299 24993003
  29. [30]Yajnik CS Early life origins of insulin resistance and type 2 diabetes in India and other Asian countries J Nutr 2004 1 134 1 205 10 14704320
  30. [31]Zambrano E Martínez-Samayoa PM Rodríguez-González GL Nathanielsz PW Dietary intervention prior to pregnancy reverses metabolic programming in male offspring of obese rats J Physiol 2010 5 15 588 Pt 10 1791 9 20351043 PMC2887995
  31. [32]Howie GJ Sloboda DM Kamal T Vickers MH Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet J Physiol 2009 2 15 587 Pt 4 905 15 19103681 PMC2669979
  32. [33]Morris MJ Chen H Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth Int J Obes (Lond) 2009 1 33 1 115 22 18982008
  33. [34]O’Regan D Kenyon CJ Seckl JR Holmes MC Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology Am J Physiol Endocrinol Metab 2004 11 287 5 E863 70 15238353
  34. [35]Tokunaga H Postnatal development of the blood vasculature in the rat adrenal gland: a scanning electron microscope study of microcorrosion casts Arch Histol Cytol 1996 10 59 4 305 15 8937631
  35. [36]Armitage JA Lakasing L Taylor PD Balachandran AA Jensen RI Dekou V Ashton N Nyengaard JR Poston L Developmental programming of aortic and renal structure in offspring of rats fed fat-rich diets in pregnancy J Physiol 2005 5 15 565 Pt 1 171 84 15774514 PMC1464506
  36. [37]Dong M Zheng Q Ford SP Nathanielsz PW Ren J Maternal obesity, lipotoxicity and cardiovascular diseases in offspring J Mol Cell Cardiol 2013 2 55 111 6 22982026
  37. [38]Bayol SA Simbi BH Bertrand JA Stickland NC Offspring from mothers fed a ‘junk food’ diet in pregnancy and lactation exhibit exacerbated adiposity that is more pronounced in females J Physiol 2008 7 1 586 13 3219 30 18467362 PMC2538787
  38. [39]Freedman DS Jacobsen SJ Barboriak JJ Sobocinski KA Anderson AJ Kissebah AH Sasse EA Gruchow HW Body fat distribution and male/female differences in lipids and lipoproteins Circulation 1990 5 81 5 1498 506 2110035
  39. [40]Elahi MM Cagampang FR Mukhtar D Anthony FW Ohri SK Hanson MA Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice Br J Nutr 2009 8 102 4 514 9 19203419
  40. [42]Aagaard-Tillery KM Grove K Bishop J Ke X Fu Q McKnight R Lane RH Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome J Mol Endocrinol 2008 8 41 2 91 102 18515302 PMC2959100
  41. [43]Purcell RH Sun B Pass LL Power ML Moran TH Tamashiro KL Maternal stress and high-fat diet effect on maternal behavior, milk composition, and pup ingestive behavior Physiol Behav 2011 9 1 104 3 474 9 21605577 PMC3142767

Authors
Desai, M., Jellyman, J. K., Han, G., Beall, M., Lane, R. H., & Ross, M. G.
Affiliations
  • University of California, Los Angeles (US)
  • The Lundquist Institute (US)
  • Medical College of Wisconsin (US)
Corresponding author
Desai, Mina
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2014-09
Volume
211
Issue
3
Pages
237.e1-237.e13
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2014.03.025
PMC
PMC4149836
OpenAlex
W2093134366
Cited by
244
References
46
Citations by year
2026: 11 · 2025: 17 · 2024: 12 · 2023: 19 · 2022: 21 · 2021: 22 · 2020: 28 · 2019: 26 · 2018: 26 · 2017: 27 · 2016: 20 · 2015: 13 · 2014: 2
FWCI
19.45
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
Funders
National Institutes of Health (R01DK081756, R01HD054751)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
Keywords
maternal obesity, high-fat diet, metabolic syndrome, developmental programming, offspring adiposity, hyperglycemia, insulin resistance, insulin deficiency, systolic blood pressure, corticosterone, pregnancy, lactation, cross-fostering, rat model
MeSH terms
Animals, Body Composition, Corticosterone, Eating, Female, Lactation, Lipids, Male, Obesity, Pregnancy, Rats, Sprague-Dawley, Metabolic Syndrome, Maternal Nutritional Physiological Phenomena, Rats, Diet, High-Fat

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review