Disseminated intravascular coagulation in pregnancy: insights in pathophysiology, diagnosis and management
Abstract
Disseminated intravascular coagulation (DIC) is a life-threatening situation that can arise from a variety of obstetrical and nonobstetrical causes. Obstetrical DIC has been associated with a series of pregnancy complications including the following: (1) acute peripartum hemorrhage (uterine atony, cervical and vaginal lacerations, and uterine rupture); (2) placental abruption; (3) preeclampsia/eclampsia/hemolysis, elevated liver enzymes, and low platelet count syndrome; (4) retained stillbirth; (5) septic abortion and intrauterine infection; (6) amniotic fluid embolism; and (7) acute fatty liver of pregnancy. Prompt diagnosis and understanding of the underlying mechanisms of disease leading to this complication in essential for a favorable outcome. In recent years, novel diagnostic scores and treatment modalities along with bedside point-of-care tests were developed and may assist the clinician in the diagnosis and management of DIC. Team work and prompt treatment are essential for the successful management of patients with DIC.
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Tissue factor complexes with factor VII and activates factors IX and X.
“Tissue factor complexes with factor VII and activates factors IX and X (98).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [98]
Systemic activation of coagulation leads to widespread formation of microvascular thrombi in small vessels and endothelial injury with concomitant fibrinolysis, a process that consumes platelets and clotting factors.
“Systemic activation of coagulation ensues, leading to the widespread formation of microvascular thrombi in small vessels and endothelial injury with concomitant fibrinolysis, a process that consumes platelets and clotting factors (98).”
From Placental abruption at near-term and term gestations: Pathophysiology, epidemiology, diagnosis, and management (2023) · cites this paper as [98]
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References 117 · Cited by 170
- Authors
- Erez, O., Mastrolia, S. A., & Thachil, J.
- Affiliations
- Ben-Gurion University of the Negev (IL)
- Manchester Royal Infirmary (GB)
- Corresponding author
- Erez, Offer
- Venue
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier BV
- Published
- 2015-10
- Volume
- 213
- Issue
- 4
- Pages
- 452-463
- ISSN
- 0002-9378 (ISSN-L)
- OpenAlex
- W2016186911
- Cited by
- 170
- References
- 117
- Citations by year
- 2026: 14 · 2025: 18 · 2024: 19 · 2023: 14 · 2022: 23 · 2021: 12 · 2020: 21 · 2019: 16 · 2018: 10 · 2017: 12 · 2016: 10 · 2015: 1
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Obstetrics and Gynecology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Maternal and fetal healthcare
- Keywords
- disseminated intravascular coagulation, pregnancy complications, peripartum hemorrhage, placental abruption, HELLP syndrome, septic abortion, amniotic fluid embolism, acute fatty liver of pregnancy, point-of-care testing, diagnostic score, pathophysiology, management
- MeSH terms
- Abortion, Septic, Abruptio Placentae, Disseminated Intravascular Coagulation, Eclampsia, Fatty Liver, Female, Fetus, Postpartum Hemorrhage, Humans, Pre-Eclampsia, Pregnancy, Pregnancy Complications, Pregnancy Complications, Hematologic, Uterine Hemorrhage, Uterine Rupture, HELLP Syndrome, Stillbirth
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