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Cited by 163Telomeres, Telomerase, and SenescencePreterm Birth and ChorioamnionitisReproductive System and Pregnancy

Chorioamniotic membrane senescence: a signal for parturition?

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Behnia, Faranak, Taylor, Brandie D., Woodson, Michael, Kacerovsky, Marian, Hawkins, Hal, Fortunato, Stephen J., Saade, George R., Menon, Ramkumar·2015·American Journal of Obstetrics and Gynecology
DOI 10.1016/j.ajog.2015.05.041
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Abstract

Objective Senescence is an important biological phenomenon involved in both physiologic and pathologic processes. We propose that chorioamniotic membrane senescence is a mechanism associated with human parturition. The present study was conducted to explore the association between senescence and normal term parturition by examining the morphologic and biochemical evidences in chorioamniotic membranes.Study design Chorioamniotic membranes were collected from normal term deliveries; group 1: term labor and group 2: term, not in labor. Senescence-related morphologic changes were determined by transmission electron microscopy and biochemical changes were studied by senescence-associated (SA) β-galactosidase staining. Amniotic fluid samples collected from both term labor and term not in labor were analyzed for 14 SA secretory phenotype (SASP) markers.Results Morphologic evidence of cellular senescence (enlarged cells and organelles) and a higher number of SA β-galactosidase-stained amnion and chorion cells were observed in chorioamniotic membranes obtained from women in labor at term, when compared to term not in labor. The concentration of proinflammatory SASP markers (granulocyte macrophage colony-stimulating factor, interleukin-6 and -8) was significantly higher in the amniotic fluid of women in labor at term than women not in labor. In contrast, SASP factors that protect against cell death (eotaxin-1, soluble Fas ligand, osteoprotegerin, and intercellular adhesion molecule-1) were significantly lower in the amniotic fluid samples from term labor.Conclusion Morphologic and biochemical features of senescence were more frequent in chorioamniotic membranes from women who experienced term labor. Senescence of chorioamniotic membranes were also associated with amniotic fluid SASP markers.

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Authors
Behnia, F., Taylor, B. D., Woodson, M., Kacerovsky, M., Hawkins, H., Fortunato, S. J., Saade, G. R., & Menon, R.
Affiliations
  • The University of Texas Medical Branch at Galveston (US)
  • Texas A&M Health Science Center (US)
Corresponding author
Menon, Ramkumar
ORCID
Venue
American Journal of Obstetrics and Gynecology
Publisher
Elsevier BV
Published
2015-09
Volume
213
Issue
3
Pages
359.e1-359.e16
ISSN
0002-9378 (ISSN-L)
DOI
10.1016/j.ajog.2015.05.041
OpenAlex
W1894868021
Cited by
163
References
129
Citations by year
2026: 9 · 2025: 14 · 2024: 13 · 2023: 13 · 2022: 16 · 2021: 11 · 2020: 23 · 2019: 22 · 2018: 13 · 2017: 15 · 2016: 11 · 2015: 3
FWCI
10.32
Type
journal article
Language
en
Open access
Licence
Locations
  • American Journal of Obstetrics and Gynecology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Health Sciences › Medicine › Epidemiology › Preterm Birth and Chorioamnionitis
  • Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Keywords
cellular senescence, fetal membranes, childbirth, term labor, senescence-associated β-galactosidase, senescence-associated secretory phenotype, amniotic fluid, chorion, amniotic membrane, inflammatory cytokines, interleukin-6, interleukin-8, GM-CSF, eotaxin, soluble Fas ligand, osteoprotegerin, ICAM-1
MeSH terms
Adult, Amnion, Amniotic Fluid, beta-Galactosidase, Chorion, Cross-Sectional Studies, Female, Humans, Labor, Obstetric, Mitochondria, Pregnancy, Interleukin-6, Case-Control Studies, Granulocyte-Macrophage Colony-Stimulating Factor, Interleukin-8, Cellular Senescence, Intercellular Adhesion Molecule-1, Term Birth, Fas Ligand Protein, Osteoprotegerin, Chemokine CCL11, Young Adult

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