Cited by 449Reproductive tract infections researchGynecological conditions and treatmentsReproductive Health and Technologies

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Sexually transmitted diseases and infertility

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Tsevat, Danielle G., Wiesenfeld, Harold C., Parks, Caitlin, Peipert, Jeffrey F.·2017·American Journal of Obstetrics and Gynecology

DOI 10.1016/j.ajog.2016.08.008PMC PMC5193130

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Abstract

Female infertility, including tubal factor infertility, is a major public health concern worldwide. Most cases of tubal factor infertility are attributable to untreated sexually transmitted diseases that ascend along the reproductive tract and are capable of causing tubal inflammation, damage, and scarring. Evidence has consistently demonstrated the effects of Chlamydia trachomatis and Neisseria gonorrhoeae as pathogenic bacteria involved in reproductive tract morbidities including tubal factor infertility and pelvic inflammatory disease. There is limited evidence in the medical literature that other sexually transmitted organisms, including Mycoplasma genitalium, Trichomonas vaginalis, and other microorganisms within the vaginal microbiome, may be important factors involved in the pathology of infertility. Further investigation into the vaginal microbiome and other potential pathogens is necessary to identify preventable causes of tubal factor infertility. Improved clinical screening and prevention of ascending infection may provide a solution to the persistent burden of infertility.

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See all 449

Authors: Tsevat, D. G., Wiesenfeld, H. C., Parks, C., & Peipert, J. F.
Affiliations: Washington University in St. Louis (US)
University of Pittsburgh (US)
Indiana University Indianapolis (US)
Corresponding author: Peipert, Jeffrey F.
ORCID: Tsevat, Danielle G.
Wiesenfeld, Harold C.
Parks, Caitlin
Peipert, Jeffrey F.
Venue: American Journal of Obstetrics and Gynecology
Publisher: Elsevier BV
Published: 2017-01
Volume: 216
Issue: 1
Pages: 1-9
ISSN: 0002-9378 (ISSN-L)
DOI: 10.1016/j.ajog.2016.08.008
PMC: PMC5193130
OpenAlex: W2560903427
Cited by: 449
References: 132
Citations by year: 2026: 39 · 2025: 55 · 2024: 64 · 2023: 51 · 2022: 63 · 2021: 66 · 2020: 51 · 2019: 32 · 2018: 18 · 2017: 8
FWCI: 2.24
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: American Journal of Obstetrics and Gynecology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Funders: National Institutes of Health (KL2TR000450)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
Keywords: sexually transmitted infections, female infertility, tubal infertility, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma genitalium, Trichomonas vaginalis, pelvic inflammatory disease, ascending infection, salpingitis, vaginal microbiota, infertility screening
MeSH terms: Pelvic Inflammatory Disease, Chlamydia Infections, Chlamydia trachomatis, Female, Gonorrhea, Humans, Infertility, Female, Mycoplasma Infections, Neisseria gonorrhoeae, Sexually Transmitted Diseases, Trichomonas vaginalis, Trichomonas Vaginitis, Mycoplasma genitalium

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