Progranulin is a chemoattractant for microglia and stimulates their endocytic activity
Pickford, Fiona, Marcus, Jacob, Camargo, Luiz Miguel, Xiao, Qiurong, Graham, Danielle, Mo, Jan-Rung, Burkhardt, Matthew, Kulkarni, Vinayak +3 more·2011·The American Journal of Pathology
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- Progranulin and Inflammation/NeuroinflammationMasato Hosokawa · 2019 · Springer eBooks
- Premature termination codon readthrough restores progranulin expression in preclinical models of frontotemporal dementia and neuronal ceroid lipofuscinosisJonathan Frew · 2021 · cIRcle (University of British Columbia)
- PGRN Counteracts the Associations of Abnormal Tau Proteins with Neurodegeneration and Cognitive Decline in Non-demented Adults: A Longitudinal StudyYifan Sun, Yanbing Liu, Chen‐Chen Tan, Lan Tan, Wei Xu · 2025 · Molecular Neurobiology
- Preclinical and clinical investigation of VES001, an oral small molecule sortilin receptor inhibitor for the treatment of frontotemporal dementia: a first-in-human randomized placebo-controlled phase 1 trialL. Klem, Daniel Dumas, Imogen J. Swift, Sofie L. Frandsen, Ditte Nedergaard Mikkelsen, Laerke Fensbaek, Yalcin Yavuz, Okke Merton, Jesminne Castricum, Simone Prichardt et al. · 2026 · Nature Communications
- Differential lysosomal burden in the excitatory and inhibitory neurons of the FTD-GRN brain.John Joyce · 2023