Lack of Tau Proteins Rescues Neuronal Cell Death and Decreases Amyloidogenic Processing of APP in APP/PS1 Mice
Leroy, Karelle, Ando, Kunie, Laporte, Vincent, Dedecker, Robert, Suain, Valérie, Authelet, Michèle, Héraud, Céline, Pierrot, Nathalie +3 more·2012·The American Journal of Pathology
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Items 101–161 of 161
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- ALWPs Improve Cognitive Function and Regulate Aβ Plaque and Tau Hyperphosphorylation in a Mouse Model of Alzheimer’s DiseaseYoungpyo Nam, Bitna Joo, Ju‐Young Lee, Kyung‐Min Han, Ka‐Young Ryu, Young Ho Koh, Jeongyeon Kim, Ja Wook Koo, Young-Man We, Hyang‐Sook Hoe · 2019 · Frontiers in Molecular Neuroscience
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- AAV delivery of artificial miRNA targeting MAPT for the reduction of tau pathology in Alzheimer’s diseaseJessica M. Hogestyn, Erik Wischhof, Yao Chen, Tiffany Chan, Brenda Richards, Thangaaishwarya Mahendran, Johanna Adams, Daniel Dubreuil, Jie Bu, Robert Jackson et al. · 2025 · Molecular Therapy
- Toluidine blue O attenuates tau phosphorylation in N2a-APPSwe cellsSeda Önder, Kevser Biberoğlu, Melike Yuksel, Özden Tacal · 2022 · Chemico-Biological Interactions
- A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid PathologyMarie Tautou, Florian Descamps, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Patricia Melnyk, Nicolas Sergeant · 2023 · International Journal of Molecular Sciences
- Amyloid β Hypothesis in the Development of Therapeutic Agents for Alzheimer’s DiseaseAdegoke O. Adeniji, P.W. Adams, Vicky V. Mody · 2016 · Elsevier eBooks
- Intravenous Injection of PHF-Tau Proteins From Alzheimer Brain Exacerbates Neuroinflammation, Amyloid Beta, and Tau Pathologies in 5XFAD Transgenic MiceSarah Houben, Marie-Ange de Fisenne, Kunié Ando, Virginie Vanden Dries, Luc Poncelet, Zehra Yilmaz, Salwa Mansour, Robert De Decker, Jean‐Pierre Brion, Karelle Leroy · 2020 · Frontiers in Molecular Neuroscience
- The Kv7 channel opener Retigabine reduces neuropathology and alleviates behavioral deficits in APP/PS1 transgenic miceDongpei Zhuang, Nan yu, Han Shuo, Xinyao Zhang, Chuanxia Ju · 2024 · Behavioural Brain Research
- Biomarkers and Target-Specific Small-Molecule Drugs in Alzheimer’s Diagnostic and Therapeutic Research: From Amyloidosis to TauopathySheng Li, Rajiv Bhalla · 2024 · Neurochemical Research
- Small-Molecule Inhibitors of Amyloid Beta: Insights from Molecular Dynamics—Part B: Natural CompoundsMariyana Atanasova · 2025 · Pharmaceuticals
- E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain AgingMorgan Ramón‐Landreau, Cristina Sánchez‐Puelles, Noelia López‐Sánchez, Anna Lozano-Ureña, Aina M. Llabrés-Mas, José María Frade · 2022 · International Journal of Molecular Sciences
- Alzheimer’s disease and epilepsy: Research hotspots for comorbidity in the era of global agingXu Zhou, Yang Liu, Zhengjuan Wu, Xiaolu Zhang, Hua Tao · 2024 · Epilepsy & Behavior
- Dysregulation of Inositol Polyphosphate 5-Phosphatase OCRL in Alzheimer’s Disease: Implications for Autophagy DysfunctionKunié Ando, May Thazin Htut, Eugenia Maria Antonelli, Andreea‐Claudia Kosa, Lidia Lopez‐Gutierrez, Carolina Quintanilla‐Sánchez, Emmanuel Aydin, Emilie Doeraene, Siranjeevi Nagaraj, Ana Raquel Ramos et al. · 2025 · International Journal of Molecular Sciences
- Axonal tau reduction ameliorates tau and amyloid pathology in a mouse model of Alzheimer’s diseaseAbdolhossein Zare, Saeede Salehi, Jakob Maximilian Bader, Anna-Lena Wiessler, Manuela Prokesch, Vincent Albrecht, Carmen Villmann, Matthias Mann, Michael Briese, Michael Sendtner · 2025 · Translational Neurodegeneration
- The Determinant of Tau Spreading in Alzheimer’s Disease: Dependent on Senile Plaque, Neural Circuits, or Spatial Proximity?Yuichi Riku, Jean‐Pierre Brion, Kunié Ando, Toshiki Uchihara, Yasushi Iwasaki · 2025 · International Journal of Molecular Sciences
- Excitoprotective effects of conditional tau reduction in excitatory neurons and in adulthoodYuliya Voskobiynyk, Zhiyong Li, J. Nicholas Cochran, M. Natalie Davis, Nancy V. N. Carullo, Rose B. Creed, Susan C. Buckingham, Alicia M. Hall, Scott M. Wilson, Erik D. Roberson · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
- Deletion of Murine APP Aggravates Tau and Amyloid Pathologies in the 5xFADXTg30 Alzheimer’s Disease ModelKunié Ando, Andreea‐Claudia Kosa, Yasmina Mehadji, Hinde Lasri, Lidia Lopez‐Gutierrez, Carolina Quintanilla‐Sánchez, Emmanuel Aydin, Emilie Doeraene, Alain Wathelet‐Depauw, Siranjeevi Nagaraj et al. · 2025 · Biomolecules
- Chondroitin Sulfate‐Coated Heteroduplex‐Molecular Spherical Nucleic AcidsToni Laine, Prasannakumar Deshpande, Ville Tähtinen, Eleanor T. Coffey, Pasi Virta · 2024 · ChemBioChem
- Sex-specific changes in energy demand during the preplaque stage in a transgenic Alzheimer’s mouse modelRongwan Sun, Leonie-Kim Zimbalski, Stefanie Schreyer, David Baidoe‐Ansah, Aida Harutyunyan, Arnd Heuser, Rachel N. Lippert, Joachim Spranger, Knut Mai, Sebastian Brachs · 2025 · Biology of Sex Differences
- Nanoscopic Mapping of the Extracellular Space in Amyloid Plaque‐rich CortexJuan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Évelyne Doudnikoff, Thierry Lesté-Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc et al. · 2025 · Advanced Science
- PolyGR-containing aggregates link with pathology and clinical features of Alzheimer’s diseaseHuong T. Phuong, Rodrigo Francisco Tomas, Cemal Akmese, Ana María Piddo Mijares, Isabella M. Gerstin, Shu Guo, Logan R. Bell, Ross Ellwood, Svitlana Yegorova, Stefani K. Ng et al. · 2025 · Acta Neuropathologica
- Application of the Movable Type Free Energy Method to the Caspase-Inhibitor Binding Affinity StudySong Xue, Hao Liu, Zheng Zheng · 2019 · International Journal of Molecular Sciences
- Alzheimer’s diseaseCharles J. Duyckaerts · 2014 · Cambridge University Press eBooks
- Moderate Overexpression of Tau in Drosophila Exacerbates Amyloid-β-Induced Neuronal Phenotypes and Correlates with Tau OligomerizationLaëtitia Miguel, Thierry Frébourg, Dominique Campion, Magalie Lecourtois · 2020 · Journal of Alzheimer s Disease
- Effect of the Icelandic Mutation APPA673T in the Murine APP Gene on Phenotype of Line 66 Tau MiceAnne Anschuetz, Lianne Robinson, Miguel Mondésir, Valeria Melis, Bettina Platt, Charles R. Harrington, Gernot Riedel, Karima Schwab · 2025 · Biomolecules
- Targeting cholinergic cells in a mouse model of Alzheimer's disease: Validating a quadruple transgenic modelSzidónia Farkas, Viktor Jasper, Kinga Nyers-Marosi, Bence Petrovai, Adrienn Szabó, Erika Kvak, Csenge Sólyomvári, Réka Varga, Viktória Kormos, Géza Makkai et al. · 2026 · Experimental Neurology
- Contribution of Nucleic Acids in the Pathogenesis of Alzheimer’s DiseaseA. A. Farooqui · 2017 · Elsevier eBooks
- Nano/Micro-Assisted Regenerative MedicineSoo-Hong Lee · 2018 · MDPI eBooks
- Tau Ablation Rewires Brain Cell Programs in Health and Restores Function in DiseaseChimal-Juárez, Enrique, Patel, Henika, Jury-Garfe, Nur, Dabin, Luke C., Vidal, Ruben, Kim, Jungsu, Lasagna-Reeves, Cristian A. · 2026 · bioRxiv
- Factors that Contribute to de novo Protein Misfolding and Prion Formation in Saccharomyces cerevisiaeKathryn M. Keefer · 2017 · Open Scholarship Institutional Repository (Washington University in St. Louis)
- The Interplay of Progestins, Matrix Metalloproteinases, and the Aging BrainKeyana Nicole Porter · 2020
- The Longitudinal Relationships between Biomarkers of Alzheimer’s DiseaseSaffire Hanna Krance · 2019 · TSpace (University of Toronto)
- INVESTIGATION INTO THE FUNCTIONAL ROLES OF TAU AND ALPHA-SYNUCLEIN IN NEURODEGENERATIVE DISEASEMeaghan Morris · 2014
- Quantification and Analysis of Tau Protein Effects on Microtubule Dynamics in Mammalian (LLC-PK1) CellsAlexandra Doersch · 2020 · University of Minnesota Digital Conservancy (University of Minnesota)
- N-truncated Aβ4-x peptides in Alzheimer's disease: generation, degradation, and relationship with neuropathological hallmarksSilvia Zampar · 2021
- Faculty Opinions recommendation of Tau deletion reduces plaque-associated BACE1 accumulation and decelerates plaque formation in a mouse model of Alzheimer's disease.Riqiang Yan · 2019 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
- Quantitative Analysen hippocampaler Interneuronen in zwei transgenen Alzheimer MausmodellenNaomi Kristin Giesers · 2022
- Prevention of tau accumulation through inhibition of hnRNP R-dependent axonal Mapt mRNA localizationAbdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
- Decoding Amyloid Plaque Penetrability: Exploring Extracellular Space and Rheology in Plaque-rich CortexJuan Estaún‐Panzano, Yulia Dembitskaya, Ivo Calaresu, Somen Nandi, Quentin Gresil, Évelyne Doudnikoff, Thierry Lesté-Lasserre, Thierry Amédée, Laurent Cognet, Laurent Groc et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
- Molecular chaperones as therapeutic gatekeepers in Alzheimer’s disease: Intersections with Tau aggregation, amyloid burden, and neuroinflammationYukti, Anushka Sharma, Sarthak Dhar, Rupal Ojha, Vijay Kumar Prajapati · 2025 · Advances in protein chemistry and structural biology
- Investigation of three flavonoids as potent tau aggregation inhibitors and In vivo demonstration of myricetinBogdan M. Benin, Trae Hillyer, Bovinari Alistair Csubak, Noah Aguirre, Samuel D. Crish, Chounghun Kang, Woo Shik Shin · 2025 · Pharmacological Research - Natural Products
- Additional file 4 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Bernard Laurent Schneider · 2020 · Figshare
- Additional file 2 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Bernard Laurent Schneider · 2020 · Figshare
- Additional file 5 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Bernard Laurent Schneider · 2020 · Figshare
- Additional file 3 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Schneider, Bernard L. · 2020 · Figshare
- Additional file 1 of Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD miceDorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein‐Tsalkovich, Dorit Trudler, Shani Blanga‐Kanfi, Hagit Eldar-Finkelman, Jens Pahnke et al. · 2023 · Figshare
- Additional file 2 of Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD miceDorit Farfara, Meital Sooliman, Limor Avrahami, Tabitha Grace Royal, Shoshik Amram, Lea Rozenstein‐Tsalkovich, Dorit Trudler, Shani Blanga‐Kanfi, Hagit Eldar-Finkelman, Jens Pahnke et al. · 2024 · Figshare
- Additional file 6 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Schneider, Bernard L. · 2020 · Figshare
- Additional file 1 of Anti-Aβ antibodies bound to neuritic plaques enhance microglia activity and mitigate tau pathologyVanessa Laversenne, Sameer Nazeeruddin, Emma Källstig, Colin, Philippe, Christel Voize, Schneider, Bernard L. · 2020 · Figshare
- Transmission of Alzheimer pathology in murine and primate models : from proteinopathies to neuronal and cognitive impairmentsSuzanne Lam · 2021 · theses.fr (ABES)
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- Tau reduction counteracts transcriptomic and behavioral abnormalities in an Alzheimer amyloid modelSara J. Knowles, Cathrine Sant, Pranav Nambiar, Rafaella Araujo Gonçalves, Kaitlyn Ho, Gui-Qiu Yu, Reuben Thomas, Megumi Mori, Lane Domke, Victor Huang et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Effect of tau silencing on tau pathology propagation, a treatment efficient at the earliest stages of the disease?Andreea‐Claudia Kosa, Lidia Lopez‐Gutierrez, Kunié Ando, Emilie Doeraene, Emmanuel Aydin, Hinde Lasri, Alain Wathelet‐Depauw, Karlien Pieters, David Van Morckhoven, Christine Dubois et al. · 2026 · Neurobiology of Disease
- Pathophysiological Characterization of intra‐ and extracellularly aggregated Amyloid Peptides in DementiasAnika Saul · 2013