The Early Innate Immune Response to, and Phagocyte-Dependent Entry of, Cryptococcus neoformans Map to the Perivascular Space of Cortical Post-Capillary Venules in Neurocryptococcosis

Kaufman-Francis, Keren; Djordjevic, Julianne T.; Juillard, Pierre-Georges; Lev, Sophie; Desmarini, Desmarini; Grau, Georges E.R.; Sorrell, Tania C.

doi:10.1016/j.ajpath.2018.03.015

The Early Innate Immune Response to, and Phagocyte-Dependent Entry of, Cryptococcus neoformans Map to the Perivascular Space of Cortical Post-Capillary Venules in Neurocryptococcosis

The innate immune system is the primary defense against cryptococcal infection, but paradoxically it promotes infection of the central nervous system. We performed a detailed longitudinal study of neurocryptococcosis in normal, chimeric, green fluorescent protein phagocyte-positive mice and phago…