Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice

Gee, Lucy M.V.; Barron-Millar, Ben; Leslie, Jack; Richardson, Claire; Zaki, Marco Y.W.; Luli, Saimir; Burgoyne, Rachel A.; Cameron, Rainie I.T.; Smith, Graham R.; Brain, John G.; Innes, Barbara; Jopson, Laura; Dyson, Jessica K.; McKay, Katherine R.C.; Pechlivanis, Alexandros; Holmes, Elaine; Berlinguer-Palmini, Rolando; Victorelli, Stella; Mells, George F.; Sandford, Richard N.; Palmer, Jeremy; Kirby, John A.; Kiourtis, Christos; Mokochinski, Joao; Hall, Zoe; Bird, Thomas G.; Borthwick, Lee A.; Morris, Christopher M.; Hanson, Peter S.; Jurk, Diana; Stoll, Elizabeth A.; LeBeau, Fiona E.N.; Jones, David E.J.; Oakley, Fiona

doi:10.1016/j.ajpath.2022.09.005

Anti–Cholestatic Therapy with Obeticholic Acid Improves Short-Term Memory in Bile Duct–Ligated Mice

Patients with cholestatic liver disease, including those with primary biliary cholangitis, can experience symptoms of impaired cognition or brain fog. This phenomenon remains unexplained and is currently untreatable. Bile duct ligation (BDL) is an established rodent model of cholestasis. In addit…