Cited by 1Lipoproteins and Cardiovascular HealthPharmacy and Medical PracticesPharmaceutical Practices and Patient Outcomes

IMPLEMENTATION OF SPECIALTY CLINICAL PHARMACIST IN A PREVENTIVE CARDIOLOGY CLINIC

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Joy, Justin, Haumschild, Ryan, Sperling, Laurence, Isiadinso, Ijeoma·2023·American Journal of Preventive Cardiology

Abstract

Justin Joy has received advisory board compensation from Akcea Therapeutics and Pfizer Preventive Cardiology Best Practices PCSK9 inhibitors (PCSK9i) and icosapent ethyl have been shown to significantly improve cardiovascular outcomes in select patients at increased CV risk. Bempedoic acid is a novel adjunct low-density lipoprotein cholesterol (LDL-C) lowering agent for patients at increased risk who require further LDL-C reduction. Many barriers to access exist for these medications resulting in delays in care, and nonadherence. To address these barriers, we incorporated a clinical pharmacist within our academic preventive cardiology clinic to facilitate medication access through enhanced collaboration between the clinic and hospital-based specialty pharmacy. A single center, retrospective study of patients seen within the preventive cardiology clinic whose medications were triaged by the hospital specialty pharmacy. The aim was to assess the time from prescription order to receipt of first dose for treatment-naïve patients. The medication approval rate, financial assistance use, median LDL-C reduction, and 90-day follow-up LDL-C was collected. A total of 35 patients met inclusion criteria during the pilot period. Prescriptions included: 10 evolocumab, 18 alirocumab, 4 bempedoic acid, and 3 icosapent ethyl triaged by the specialty pharmacy. 19 (35%) patients had a clinical history of atherosclerotic cardiovascular disease (ASCVD). The majority of patients had commercial insu…

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Crossref · 10.1016/j.ajpc.2022.100415

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  • In a small mixed-prevention cohort, four patients received bempedoic acid and achieved a 34% LDL-C reduction at 3 months.

    “Lastly, in a small mixed-prevention cohort, four patients received bempedoic acid and achieved a 34% LDL-C reduction at 3 months (baseline LDL-C = 146 mg/dL); no further treatment details were provided [34].”
  • LDL-C reductions with bempedoic acid in statin-intolerant patients ranged from 22% to 38%.

    “Consistent effects were also seen when bempedoic acid was added to statins (15% to 39%) [25,30,32,38,39,44], and when used in statin intolerant patients (22% to 38%) [24,29,34,35,37,40,41], despite the latter group having higher baseline LDL-C.”

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Cited by 1

Authors
Joy, J., Haumschild, R., Sperling, L., & Isiadinso, I.
Affiliations
  • Emory Healthcare (US)
  • Emory University (US)
Corresponding author
Joy, Justin
Venue
American Journal of Preventive Cardiology
Publisher
Elsevier BV
Published
2023-03
Volume
13
Pages
100415
ISSN
2666-6677 (ISSN-L)
OpenAlex
W4317660799
Cited by
1
References
0
Citations by year
2026: 1
FWCI
0.27
Type
journal article
Language
en
Open access
Locations
  • American Journal of Preventive Cardiology (publishedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacy and Medical Practices
  • Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
Keywords
clinical pharmacists, preventive cardiology, PCSK9 inhibitors, evolocumab, alirocumab, bempedoic acid, icosapent ethyl, specialty pharmacy, access to medicines, prior authorization, financial aid, LDL cholesterol lowering, statin intolerance, atherosclerotic cardiovascular disease, medication adherence, barriers to care

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