Left ventricular function in children with sleep-disordered breathing
Abstract
Severe obstructive sleep apnea in children leads to congestive heart failure. We studied the early changes in left ventricular function across a range of severity of the disorder. A dose-dependent decrease in diastolic function with increased severity of obstructive apnea was demonstrated.
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Obstructive sleep apnea is a highly prevalent syndrome associated with substantial morbidity and increased mortality.
“OBSTRUCTIVE SLEEP APNEA (OSA) IS A HIGHLY PREV-ALENT SYNDROME THAT IS ASSOCIATED WITH SUB-STANTIAL MORBIDITY AND INCREASED MORTALITY. 1-10”
Sleep-disordered breathing in children is associated with adverse cardiovascular effects including dysregulation of blood pressure and cardiac dysfunction.
“Sleep-disordered breathing in children is associated with adverse cardiovascular effects including dysregulation of blood pressure (196, 197) and cardiac dysfunction (198, 199).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [198]
Sleep-disordered breathing in children is associated with adverse cardiovascular effects including dysregulation of blood pressure and cardiac dysfunction.
“Sleep-disordered breathing in children is associated with adverse cardiovascular effects including dysregulation of blood pressure (196, 197) and cardiac dysfunction (198, 199).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [196]
There is evidence for left ventricular dysfunction in children with sleep-disordered breathing.
“There is also evidence for left ventricular dysfunction (198).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [198]
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References 16 · Cited by 225
- Authors
- Amin, R. S., Kimball, T. R., Kalra, M., Jeffries, J. L., Carroll, J. L., Bean, J. A., Witt, S. A., Glascock, B. J., & Daniels, S. R.
- Affiliations
- Cincinnati Children's Hospital Medical Center (US)
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Amin, Raouf S.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 95
- Issue
- 6
- Pages
- 801-804
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W1965006942
- Cited by
- 225
- References
- 16
- Citations by year
- 2025: 2 · 2024: 9 · 2023: 3 · 2022: 9 · 2021: 7 · 2020: 7 · 2019: 10 · 2018: 8 · 2017: 10 · 2016: 10 · 2015: 8 · 2014: 6 · 2013: 7 · 2012: 14
- FWCI
- 11.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL070907, R01 HL70907-02A1)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Keywords
- obstructive sleep apnea, children, left ventricular function, diastolic function, congestive heart failure, sleep-disordered breathing, disease severity, dose-response relationship
- MeSH terms
- Adolescent, Blood Flow Velocity, Blood Pressure, Cardiac Volume, Child, Child, Preschool, Diastole, Echocardiography, Female, Heart Failure, Humans, Male, Mitral Valve, Myocardial Contraction, Oxygen, Reference Values, Risk Factors, Systole, Ventricular Function, Left, Polysomnography, Ventricular Dysfunction, Left, Sleep Apnea, Obstructive
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