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Recurrence Rates of Arrhythmias During Pregnancy in Women With Previous Tachyarrhythmia and Impact on Fetal and Neonatal Outcomes
Abstract
In women with heart disease, sustained arrhythmias can result in an increased risk to the mother and fetus. The purpose of this study was to determine the recurrence rates of arrhythmias during pregnancy in women with cardiac rhythm disorders and examine the impact on fetal and neonatal outcomes. Women with tachyarrhythmias before pregnancy who underwent obstetric care at the Toronto General and Mount Sinai Hospitals from 1990 to 2002 were included. The recurrence rates of arrhythmias were calculated. A multivariate logistic model was used to identify predictors of fetal complications. Seventy-three women had 87 pregnancies; 36 pregnancies were in women with a history of paroxysmal supraventricular tachycardia, 23 with paroxysmal atrial fibrillation or atrial flutter (AF/Afl), 6 with persistent AF/Afl, and 22 with ventricular tachycardia. In the women in sinus rhythm at baseline, 44% (36 of 81 pregnancies) developed recurrences of tachyarrhythmias during pregnancy or in the early postpartum period. The specific recurrence rates during pregnancy in women with a history of supraventricular tachycardia, paroxysmal AF/Afl, and ventricular tachycardia were 50%, 52%, and 27%, respectively. The 6 women in AF/Afl at baseline remained in this rhythm throughout their pregnancy. Adverse fetal events occurred in 17 of the 87 pregnancies (20%). Adverse fetal events occurred more commonly in women who developed antepartum arrhythmias (RR 3.4, 95% confidence interval 1.0 to 11.0, p = 0.045) compared with those who did not. In conclusion, in women with preexisting cardiac rhythm disorders, exacerbation of arrhythmia during pregnancy is common. Recurrence of arrhythmia during the antepartum period increases the risk of adverse fetal complications, independent of other maternal and fetal risk factors.
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“AF is associated with increased complications for the mother and foetus.911,912”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [911]
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Cites
Prospective Multicenter Study of Pregnancy Outcomes in Women With Heart Disease
Siu, S. C., Sermer, M., Colman, J. M., Alvarez, A. N., Mercier, L., Morton, B. C., Kells, C. M., Bergin, M. L., Kiess, M. C., Marcotte, F., et al. (2001) · Circulation · doi:10.1161/hc3001.093437 · Cited by 1,401
ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation: executive summary
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01587-x · Cited by 1,362
Blomstrom-Lundqvist (2003) · doi:10.1161/01.cir.0000091380.04100.84 · Cited by 955
Use of Antithrombotic Agents During Pregnancy
Ginsberg, J. S., & Hirsh, J. (1995) · CHEST Journal · doi:10.1378/chest.108.4_supplement.305s · Cited by 660
Fúster, & Westerling, R. (2001) · Circulation · Cited by 607
Fuster, V., Rydén, L., ASINGER, R. W., Cannom, D. S., Crijns, H. J. G. M., Frye, R. L., Halperin, J. L., Kay, G. N., Klein, W. W., Lévy, S., et al. (2001) · Circulation · doi:10.1161/circ.104.17.2118 · Cited by 607
Use of Antithrombotic Agents During Pregnancy
Bates, S. M., Greer, I. A., Hirsh, J., & Ginsberg, J. S. (2004) · CHEST Journal · doi:10.1378/chest.126.3_suppl.627s · Cited by 550
Drici, M., Burklow, T. R., Haridasse, V., Glazer, R. I., & Woosley, R. L. (1996) · Circulation · doi:10.1161/01.cir.94.6.1471 · Cited by 371
Adverse Neonatal and Cardiac Outcomes Are More Common in Pregnant Women With Cardiac Disease
Siu, S. C., Colman, J. M., Sorensen, S., Smallhorn, J. F., Farine, D., Amankwah, K. S., Spears, J. C., & Sermer, M. (2002) · Circulation · doi:10.1161/01.cir.0000015699.48605.08 · Cited by 369
Neurodevelopment and Predictors of Outcomes of Children With Birth Weights of Less Than 1000 g
Hack, M., Wilson-Costello, D. E., Friedman, H., Taylor, G. H., SCHLUCHTER, M. D., & Fanaroff, A. A. (2000) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.154.7.725 · Cited by 356
Pregnancy and its outcome in women with and without surgical treatment of congenital heart disease
Whittemore, R., Hobbins, J. C., & Engle, M. A. (1982) · The American Journal of Cardiology · doi:10.1016/0002-9149(82)90334-4 · Cited by 346
Risk and Predictors for Pregnancy-Related Complications in Women With Heart Disease
SM, S. C. S., Sermer, M., Harrison, D. A., Grigoriadis, E., Liu, G., Sorensen, S., Smallhorn, J. F., Farine, D., Amankwah, K. S., Spears, J. C., et al. (1997) · Circulation · doi:10.1161/01.cir.96.9.2789 · Cited by 317
Amiodarone Therapy for Drug-Refractory Fetal Tachycardia
Strasburger, J. F., Cuneo, B. F., Michon, M. M., Gotteiner, N. L., Deal, B. J., McGregor, S. N., Oudijk, M. A., Meijboom, E. J., Feinkind, L., Hussey, M. A., et al. (2004) · Circulation · doi:10.1161/01.cir.0000109494.05317.58 · Cited by 210
Bartalena, L., Bogazzi, F., Braverman, L. E., & Martino, E. (2001) · Journal of Endocrinological Investigation · doi:10.1007/bf03343825 · Cited by 199
Ventricular arrhythmias in postoperative tetralogy of Fallot
Chandar, J. S., Wolff, G. S., Garson, A., BELL, T. J., Beder, S. D., Bink‐Boelkens, M. T. E., Byrum, C. J., Campbell, R. M., Deal, B. J., Dick, M., et al. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)91047-a · Cited by 198
Psychiatric sequelae of low birth weight at 6 years of age
Breslau, N., Brown, G. G., DelDotto, J. E., Kumar, S., Ezhuthachan, S., Andreski, P. M., & Hufnagle, K. G. (1996) · Research on Child and Adolescent Psychopathology · doi:10.1007/bf01441637 · Cited by 157
The Idiopathic Long QT Syndrome: Pathogenetic Mechanisms and Therapy
Schwartz, P. J., & Locati, E. H. (1985) · European Heart Journal · doi:10.1093/eurheartj/6.suppl_d.103 · Cited by 150
Effects of pregnancy on first onset and symptoms of paroxysmal supraventricular tachycardia
Shih-Huang, L., Shih-Ann, C., Tsu-Juey, W., Chern-En, C., Chen-Chuen, C., Ching-Tai, T., Chuen-Wang, C., Kwo-Chang, U., & Mau-Song, C. (1995) · The American Journal of Cardiology · doi:10.1016/s0002-9149(99)80195-7 · Cited by 146
Effect of pregnancy on paroxysmal supraventricular tachycardia
Tawam, M., Levine, J., Mendelson, M., Goldberger, J., Dyer, A., & Kadish, A. (1993) · The American Journal of Cardiology · doi:10.1016/0002-9149(93)91078-v · Cited by 144
Pregnancy outcome after gestational exposure to amiodarone in Canada
Magee, L. A., Downar, E., Sermer, M., Boulton, B. C., Allen, L. C., & Koren, G. (1995) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(95)91498-6 · Cited by 142
A Gradient Relationship Between Low Birth Weight and IQ at Age 6 Years
Breslau, N. (1994) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1994.02170040043007 · Cited by 141
Serial follow-up of adults with repaired tetralogy of Fallot
Waien, S. A., Liu, P. P., Ross, B. L., Williams, W. G., Webb, G. D., & McLaughlin, P. R. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90093-3 · Cited by 102
Amiodarone therapy during pregnancy
McKenna, W. J., Harris, L., Rowland, E., Storey, G., & Holt, D. (1983) · The American Journal of Cardiology · doi:10.1016/0002-9149(83)90377-6 · Cited by 96
Antiarrhythmic effect and its underlying ionic mechanism of 17β‐estradiol in cardiac myocytes
Nakajima, T., Iwasawa, K., Oonuma, H., Morita, T., Goto, A., Wang, Y., & Hazama, H. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702576 · Cited by 84
Disorders of the heartbeat during pregnancy
Mendelson, C. L. (1956) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(56)90787-6 · Cited by 81
Autonomic cardiovascular reflexes in pregnancy. A longitudinal study
Ekholm, E. M. K., Piha, S. J., Erkkola, R., & Antila, K. (1994) · Clinical Autonomic Research · doi:10.1007/bf01826181 · Cited by 70
Management of Cardiac Arrhythmias during Pregnancy
Rotmensch, H. H., Rotmensch, S., & Elkayam, U. (1987) · Drugs · doi:10.2165/00003495-198733060-00005 · Cited by 69
The Idiopathic Long Q-T Syndrome
Schwartz, P. J. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-99-4-561 · Cited by 59
Doppler Echocardiography During Pregnancy
Campos, O. (1996) · Echocardiography · doi:10.1111/j.1540-8175.1996.tb00881.x · Cited by 56
Hypertrophic Cardiomyopathy and Pregnancy
Shah, D. M., & Sunderji, S. G. (1985) · Obstetrical & Gynecological Survey · doi:10.1097/00006254-198507000-00005 · Cited by 48
Atrial Fibrillation and Pregnancy
Szekely, P., & Snaith, L. (1961) · BMJ · doi:10.1136/bmj.1.5237.1407 · Cited by 35
Hypertrophic cardiomyopathy and pregnancy
Piacenza, J. M., Kirkorian, G., Audra, P., & Mellier, G. (1998) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(98)00076-1 · Cited by 19
Research works printed but not linked: 1
- 2000, Guidelines 2000 for cardiopulmonary resuscitation and emergency cardiovascular care. Part 6: advanced cardiovascular life support; section 7: algorithm approach to ACLS emergencies: section 7A: principles and practice of ACLS, Circulation, 102, I136
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Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418
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Regitz-Zagrosek, V., Roos-Hesselink, J. W., Bauersachs, J., Blomström-Lundqvist, C., Cífková, R., De Bonis, M., Iung, B., Johnson, M. R., Kintscher, U., Kranke, P., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy340 · Cited by 2,292
Self-citation
Metadata
- Authors
- Silversides, C. K., Harris, L., Haberer, K., Sermer, M., Colman, J. M., & Siu, S. C.
- Affiliations
- Mount Sinai Hospital (CA)
- University Health Network (CA)
- Corresponding author
- Silversides, Candice K.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2006-04
- Volume
- 97
- Issue
- 8
- Pages
- 1206-1212
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W2137412626
- Cited by
- 255
- References
- 32
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 11 · 2023: 18 · 2022: 16 · 2021: 17 · 2020: 16 · 2019: 12 · 2018: 13 · 2017: 20 · 2016: 18 · 2015: 17 · 2014: 11 · 2013: 7 · 2012: 11
- FWCI
- 5.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- pregnancy, paroxysmal supraventricular tachycardia, paroxysmal atrial fibrillation, atrial flutter, ventricular tachycardia, fetal complications, neonatal outcomes, cardiac disease in pregnancy
- MeSH terms
- Adult, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cerebral Hemorrhage, Female, Fetal Death, Heart Defects, Congenital, Humans, Infant, Newborn, Infant, Small for Gestational Age, Pregnancy, Pregnancy Complications, Cardiovascular, Puerperal Disorders, Recurrence, Respiratory Distress Syndrome, Newborn, Multivariate Analysis, Premature Birth
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