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Spectrum and Significance of Electrocardiographic Patterns, Troponin Levels, and Thrombolysis in Myocardial Infarction Frame Count in Patients With Stress (Tako-tsubo) Cardiomyopathy and Comparison to Those in Patients With ST-Elevation Anterior Wall Myocardial Infarction
Abstract
Stress (takotsubo) cardiomyopathy (SC) is a recently recognized syndrome with clinical and electrocardiographic (ECG) presentation resembling ST elevation anterior myocardial infarction. As experience with this condition has evolved, a more diverse spectrum of 12-lead ECG patterns has emerged that may affect differential diagnosis. Fifty-nine consecutive patients with SC were prospectively identified at a large community-based cardiology practice. All were women aged 32 to 90 years (mean 66+/-13) with acute chest pain triggered by emotional or physical incidents and with akinesia of the mid-distal left ventricle; each patient recovered and was discharged within a median of 4 days. On electrocardiography, anterior ST elevation was most common (33 [56%]), with magnitudes less than in controls with left anterior descending coronary artery occlusions (1.4+/-1.5 vs 2.4+/-2.2 mm, p<0.001), with considerable overlap. ECG findings in 26 other patients (44%) without ST elevation revealed diffuse T-wave inversion (10 [17%]) and healed anterior infarctions (6 [10%]) or were nonspecific (5 [8.5%]) or normal (5 [8.5%]). Troponin elevations occurred in 56 patients with SC (95%). The mean peak troponin T level was significantly lower in patients with SC (0.64+/-0.86 ng/ml) than in those with left anterior descending coronary artery occlusions (3.88+/-4.9 ng/ml) (p<0.0001). Patients with SC with or without ST elevation did not differ with respect to the ejection fraction (29+/-9% vs 34+/-9%, respectively, p=NS) or Thrombolysis In Myocardial Infarction (TIMI) frame counts. During recovery, diffuse T-wave inversion evolved in 49 patients with SC (83%). In conclusion, patients with SC present with diverse ECG findings, and no single pattern alone can reliably distinguish this condition from acute coronary syndromes. The diagnosis of SC requires heightened awareness of its unique clinical profile as well as coronary arteriography and left ventriculography.
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“Scrutinizing the ECG findings in 59 female patients with stress (takotsubo) cardiomyopathy showed in 56% of the patients anterior STelevation, with magnitudes less than in controls with left anterior descending coronary artery occlusions; in other patients without ST-elevation, the ECG revealed diffuse T-wave inversion, healed anterior infarctions or nonspecific changes; in 8.5% the ECG was normal”
From The Year of 2008 in Electrocardiology (2010) · cites this paper as [29]
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Cites
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
The stunned myocardium: prolonged, postischemic ventricular dysfunction.
D, E. B. M., & Kloner, R. A. (1982) · Circulation · doi:10.1161/01.cir.66.6.1146 · Cited by 2,824
Gibson, C. M., Cannon, C. P., Daley, W. L., Dodge, J. T., Alexander, B., Marble, S. J., McCabe, C. H., Raymond, L., Fortin, T., Poole, W. K., et al. (1996) · Circulation · doi:10.1161/01.cir.93.5.879 · Cited by 1,873
Tsuchihashi, K., Ueshima, K., Uchida, T., Ohmura, N., Kimura, K., Owa, M., Yoshiyama, M., Miyazaki, S., Haze, K., Ogawa, H., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01316-x · Cited by 1,657
Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review
Gianni, M., Dentali, F., Grandi, A. M., Sumner, G., Hiralal, R., & Lonn, E. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl032 · Cited by 1,509
Bybee, K. A., Kára, T., Prasad, A., Lerman, A., Barsness, G. W., Wright, R. S., & Rihal, C. S. (2004) · Annals of Internal Medicine · doi:10.7326/0003-4819-141-11-200412070-00010 · Cited by 1,506
[Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases].
Dote, K., Sato, H., Tateishi, H., Uchida, T., & Ishihara, M. (1991) · PubMed · Cited by 1,229
Acute and Reversible Cardiomyopathy Provoked by Stress in Women From the United States
Sharkey, S. W., Lesser, J. R., Zenovich, A. G., Maron, M. S., Lindberg, J. L., Longe, T. F., & Maron, B. J. (2005) · Circulation · doi:10.1161/01.cir.0000153801.51470.eb · Cited by 1,043
Self-citationKurisu, S., Sato, H., Kawagoe, T., Ishihara, M., Shimatani, Y., Nishioka, K., Kono, Y., Umemura, T., & Nakamura, S. (2002) · American Heart Journal · doi:10.1067/mhj.2002.120403 · Cited by 898
Bybee, K. A., Prasad, A., Barsness, G. W., Lerman, A., Jaffe, A. S., Murphy, J. G., Wright, R. S., & Rihal, C. S. (2004) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.04.030 · Cited by 580
Cited by
Sorted by citations
Natural History and Expansive Clinical Profile of Stress (Tako-Tsubo) Cardiomyopathy
Sharkey, S. W., Windenburg, D. C., Lesser, J. R., Maron, M. S., Hauser, R. G., Lesser, J. N., Haas, T. S., Hodges, J. S., & Maron, B. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.057 · Cited by 903
Self-citationTroponin elevation in coronary vs. non-coronary disease
Agewall, S., Giannitsis, E., Jernberg, T., & Katus, H. A. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq456 · Cited by 606
“Most patients with Tako-tsubo cardiomyopathy have a modest rise in cTn that peaks within 24 h.(58,60) The magnitude of increase in the biomarkers is less than that observed with a STEMI and disproportionately low for the extensive acute regional wall motion abnormalities that characterize Tako-tsubo cardiomyopathy.”
BackgroundStress Cardiomyopathy Diagnosis and Treatment
de Chazal, H. M., Buono, M. G. D., Keyser‐Marcus, L., Ma, L., Moeller, F. G., Berrocal, D. H., & Abbate, A. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.07.072 · Cited by 554
Januzzi, J. L., Filippatos, G. S., Nieminen, M. S., & Gheorghiade, M. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs191 · Cited by 315
“Despite being strongly linked to spontaneous (Type I) acute myocardial infarction (MI)—a common cause of acute HF syndromes—it is well recognized that concentrations of circulating troponins above the 99th percentile of a normal population in the context of both acute and chronic HF are highly prevalent, and frequentl…”
BackgroundInfluentialDiagnosis of Takotsubo Cardiomyopathy
Scantlebury, D. C., & Prasad, A. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0859 · Cited by 288
Proposed Mayo Clinic criteria for the diagnosis of Tako-Tsubo cardiomyopathy and long-term prognosis
Madhavan, M., & Prasad, A. (2010) · Herz · doi:10.1007/s00059-010-3339-x · Cited by 285
Epidemiology, pathogenesis, and management of takotsubo syndrome
Y‐Hassan, S., & Tornvall, P. (2017) · Clinical Autonomic Research · doi:10.1007/s10286-017-0465-z · Cited by 247
“[23] did not find significant differences in TIMI frame count measurements in 59 patients with TS compared with controls.”
ResultMadias, C. A., Fitzgibbons, T. P., Alsheikh-Ali, A. A. A., Bouchard, J. L., Kalsmith, B. M., Garlitski, A. C., Tighe, D. A., Estes, N. A. M., Aurigemma, G. P., & Link, M. S. (2010) · Heart Rhythm · doi:10.1016/j.hrthm.2010.12.012 · Cited by 197
Stress Cardiomyopathy: A Syndrome of Catecholamine-Mediated Myocardial Stunning?
Wittstein, I. S. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9804-8 · Cited by 183
“Compared to patients with anterior ST-segment elevation myocardial infarction (STEMI), patients with SCM tend to have a smaller magnitude of ST-segment elevation (Sharkey et al. 2008) and are less likely to have reciprocal”
BackgroundTransient attenuation of the amplitude of the QRS complexes in the diagnosis of Takotsubo syndrome
Madias, J. E. (2013) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872613504311 · Cited by 183
Marra, M. P., Zorzi, A., Corbetti, F., Lazzari, M. D., Migliore, F., Tona, F., Tarantini, G., Iliceto, S., & Corrado, D. (2012) · Heart Rhythm · doi:10.1016/j.hrthm.2012.09.004 · Cited by 174
ECG Criteria to Differentiate Between Takotsubo (Stress) Cardiomyopathy and Myocardial Infarction
Frangieh, A. H., Obeid, S. N., Ghadri, J. R., Imori, Y., D’Ascenzo, F., Kovać, M., Ruschitzka, F. T., Lüscher, T. F., Duru, F., Templin, C., et al. (2016) · Journal of the American Heart Association · doi:10.1161/jaha.116.003418 · Cited by 175
Ono, R., & Falcão, L. M. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.012 · Cited by 152
“Concerning biomarkers, it is true no elevation of the biomarkers has been reported in about 5% of cases of this syndrome [4, 51, 52], but there is typically a slight increase in the creatine kinase MB and in troponins I and T, although at lower levels than occur with acute myocardial infarction [2,3, 39, 51,53].”
BackgroundEpidemiology and Clinical Profile of Takotsubo Cardiomyopathy
Sharkey, S. W., & Maron, B. J. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0770 · Cited by 128
Self-citationFröhlich, G., Schoch, B., Schmid, F. A., Keller, P., Sudano, I., Lüscher, T. F., Noll, G., Ruschitzka, F. T., & Enseleit, F. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.09.077 · Cited by 127
“However, neither symptoms on admission, nor ECG changes are useful in the differentiation of TC from acute myocardial infarction.[3-5] Of note, troponin, creatinekinase (CK), CKMB and myoglobin levels are only slightly elevated in the majority of patients with TC.”
BackgroundDib, C., Asirvatham, S. J., Elesber, A. A., Rihal, C. S., Friedman, P. A., & Prasad, A. (2009) · American Heart Journal · doi:10.1016/j.ahj.2008.12.023 · Cited by 126
Systolic and Diastolic Mechanics in Stress Cardiomyopathy
Medeiros, K., O’Connor, M. J., Baicu, C. F., Fitzgibbons, T. P., Shaw, P., Tighe, D. A., Zile, M. R., & Aurigemma, G. P. (2014) · Circulation · doi:10.1161/circulationaha.113.002781 · Cited by 125
“3 Introduction We and others have called attention to a peculiar form of reversible cardiomyopathy, which usually occurs in the setting of emotional or physical stress.(1-10) This syndrome of stress-related cardiomyopathy (SCM) has been given various names, in part depending on the geometric pattern of systolic dysfun…”
BackgroundAkashi, Y. J., NEF, H. M., Möllmann, H., & Ueyama, T. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.041908.191750 · Cited by 96
Coexistence and outcome of coronary artery disease in Takotsubo syndrome
Napp, L. C., Cammann, V. L., Jaguszewski, M. J., Szawan, K. A., Wischnewsky, M. B., Gili, S., Knorr, M., Heiner, S., Citro, R., Bossone, E., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehaa210 · Cited by 94
Cardiovascular Biomarkers: Lessons of the Past and Prospects for the Future
Omran, F., Kyrou, I., Osman, F., Lim, V. G., Randeva, H. S., & Chatha, K. K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23105680 · Cited by 89
Role of Coronary Microvascular Dysfunction in Takotsubo Cardiomyopathy
Vitale, C., Rosano, G. M. C., & Kaski, J. C. (2016) · Circulation Journal · doi:10.1253/circj.cj-15-1364 · Cited by 78
ST segment elevations: Always a marker of acute myocardial infarction?
Coppola, G., Carità, P., Corrado, E., Borrelli, A., Rotolo, A., Guglielmo, M., Nugara, C., Ajello, L., Santomauro, M., & Novo, S. (2013) · Indian Heart Journal · doi:10.1016/j.ihj.2013.06.013 · Cited by 74
“The temporary presence of Q waves is mainly due to necrosis of Purkinje cell and not to an irreversible myocardial damage as shown from the absence of late enhancement at cardiac magnetic resonance.(25) Kosuge et al(26) have recently presented an interesting analysis Fig.”
BackgroundTakotsubo cardiomyopathy: State-of-the-art review
Dorfman, T. A., & Iskandrian, A. E. (2009) · Journal of Nuclear Cardiology · doi:10.1007/s12350-008-9015-3 · Cited by 74
“Nevertheless, it is doubtful that TC can be distinguished from a MI based on ECG changes alone.(16,20,21)”
BackgroundMethodResultInfluentialBossone, E., Savarese, G., Ferrara, F., Citro, R., Mosca, S., Musella, F., Limongelli, G., Manfredini, R., Cittadini, A., & Filardi, P. P. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.12.015 · Cited by 69
“In general, the magnitude of cardiac biomarkers elevation is less than in ST-segment elevation myocardial infarction (STEMI) but similar in non-STEMI and disproportionately lower than the extent of LV dysfunction.(40,41) These findings may reflect the underlying pathophysiologic mechanism of myocardial stunningwith le…”
BackgroundMethodThe Sympathetic Nervous System in the Pathogenesis of Takotsubo Syndrome
Wittstein, I. S. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.06.012 · Cited by 64
Takotsubo cardiomyopathy – a clinical review
Castillo-Rivera, A. M., Ruiz-Bailén, M., & Aguilar, L. R. (2011) · Medical Science Monitor · doi:10.12659/msm.881800 · Cited by 60
Kosuge, M., & Kimura, K. (2014) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2014.03.004 · Cited by 59
“Some [3,11,13] but not all [8,12] studies have shown that the absence of abnormal Q waves, an ECG marker of irreversible myocardial necrosis, ismore common inTC than in anteriorAMI.”
BackgroundResultInfluentialClinical Profile of Patients With High-Risk Tako-Tsubo Cardiomyopathy
Sharkey, S. W., Pink, V. R., Lesser, J. R., Garberich, R., Maron, M. S., & Maron, B. J. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.05.054 · Cited by 59
Self-citationKosuge, M., Ebina, T., Hibi, K., Iwahashi, N., Tsukahara, K., Endo, M., Maejima, N., Nagashima, Z., Suzuki, H., Morita, S., et al. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-1036 · Cited by 58
Thrombolysis In Myocardial Infarction Frame Count in Takotsubo Cardiomyopathy
Khalid, N. M., Iqbal, I., Coram, R., Raza, T., Fahsah, I., & Ikram, S. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.04.192 · Cited by 51
“, unexpected death of relatives, domestic violence, arguments, catastrophic medical diagnoses, financial or gambling losses and natural disasters [2,3].”
BackgroundMethodPredictors of Short- and Long-Term Outcomes of Takotsubo Cardiomyopathy
Gopalakrishnan, M., Hassan, A. H., Villines, D. C., Nasr, S., Chandrasekaran, M., & Klein, L. W. (2015) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2015.08.024 · Cited by 51
Guerra, F., Rrapaj, E., Pongetti, G., Fabbrizioli, A., Pelizzoni, V., Giannini, I., Aschieri, D., Costantini, C., & Capucci, A. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.07.036 · Cited by 46
Summers, M. R., & Prasad, A. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.12.007 · Cited by 45
Time course of electrocardiographic changes in transient left ventricular ballooning syndrome
Bennett, J., Ferdinande, B., Kayaert, P., Wiyono, S. A., Goetschalckx, K., Dubois, C., Sinnaeve, P., Adriaenssens, T., Coosemans, M., & Desmet, W. J. (2013) · International Journal of Cardiology · doi:10.1016/j.ijcard.2013.08.126 · Cited by 45
“Furthermore, the routine early invasive approach currently recommended in high-risk acute coronary syndromes likely leads to an increased capture of TLVBS as increasing numbers of coronary angiograms with ventriculograms are being performed [10].”
BackgroundResultTakotsubo cardiomyopathy: Pathophysiology and role of cardiac biomarkers in differential diagnosis
Gopalakrishnan, P. P., Zaidi, R., & Sardar, M. R. (2017) · World Journal of Cardiology · doi:10.4330/wjc.v9.i9.723 · Cited by 46
Usefulness of ECG to differentiate Takotsubo cardiomyopathy from acute coronary syndrome
Looi, J., Wong, C.-W., Lee, M., Khan, A., Webster, M. W. I., & Kerr, A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.046 · Cited by 44
Parkkonen, O., Allonen, J., Vaara, S. M., Viitasalo, M. T., Nieminen, M. S., & Sinisalo, J. P. (2014) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2014.06.006 · Cited by 44
“Previous studies have produced differing ECG findings [2–4,6–9].”
ResultArrhythmias in Takotsubo Cardiomyopathy
Brown, K. H., Trohman, R. G., & Madias, C. A. (2015) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2015.03.015 · Cited by 43
Johnson, N. P., Chavez, J. F., Mosley, W. J., Flaherty, J. D., & Fox, J. M. (2011) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.07.029 · Cited by 39
“The initial electrocardiogram (ECG) usually demonstrates ST-segment elevation, most frequently in the anterior leads [2].”
BackgroundQT Prolongation and Clinical Outcomes in Patients with Takotsubo Cardiomyopathy
Imran, T. F., Rahman, I. U., Dikdan, S. J., Shah, R., Niazi, O. T., Thirunahari, N., Alhaj, E. K., Klapholz, M., Gaziano, J. M., & Djoussé, L. (2016) · Pacing and Clinical Electrophysiology · doi:10.1111/pace.12864 · Cited by 39
“(1) Transient systolic dysfunction of the apical or mid segments of the left ventricle; akinesia/wall motion abnormalities beyond a single coronary artery vascular distribution (2) Absence of significant coronary artery disease on coronary angiography that could be responsible for the observed wall motion abnormality…”
BackgroundTakotsubo Cardiomyopathy and Sepsis
Cappelletti, S., Ciallella, C., Aromatario, M., Ashrafian, H., Harding, S. E., & Athanasiou, T. (2016) · Angiology · doi:10.1177/0003319716653886 · Cited by 38
“The differential diagnosis can be based on the presence of relatively remarkable elevation of the concentration level of BNP compared with TnT; for this reason, Ahmed et al proposed the BNP–TnT ratio as a potential and useful tool for differential diagnosis.49 Moreover, the pattern of troponin elevation differs consid…”
MethodInfluentialHessel, E. A., & London, M. J. (2010) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3181c9fa22 · Cited by 38
Tako-Tsubo syndrome: dying of a broken heart?
Sinning, C., Keller, T., Abegunewardene, N., Kreitner, K.-F., Münzel, T. F., & Blankenberg, S. (2010) · Clinical Research in Cardiology · doi:10.1007/s00392-010-0224-9 · Cited by 36
“During TakoTsubo syndrome, changes in the ECG are a common feature most often reported from the chest leads [4, 6, 31].”
BackgroundNascimento, F. O., Yang, S. C., Larrauri-Reyes, M. C., Pineda, A. M., Cornielle, V., Santana, O., Heimowitz, T. B., Stone, G. W., & Beohar, N. (2013) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2013.10.013 · Cited by 35
Compare, A., Proietti, R., Forno, D. D., Vitelli, A., Grieco, A., Maresca, L., & Giallauria, F. (2015) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2011.197 · Cited by 31
“The onset of TTC can be triggered by an acute, intense emotional stress [1-5], but the exact pathogenic mechanisms linking emotional stress to TTC still remain undefined [6, 7].”
BackgroundLupus Myopericarditis as a Preceding Stressor for Takotsubo Cardiomyopathy
Chhabra, L., Khalid, N. M., Kluger, J., & Spodick, D. H. (2014) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2014.11929147 · Cited by 30
A Clinical Perspective of the Takotsubo Syndrome
Sharkey, S. W. (2016) · Heart Failure Clinics · doi:10.1016/j.hfc.2016.06.003 · Cited by 30
Self-citationKosuge, M., & Kimura, K. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-1119 · Cited by 29
Value of Cardiac Biomarkers in the Early Diagnosis of Takotsubo Syndrome
Dagrenat, C., Hunolstein, J. V., Matsushita, K., Lachmet-Thébaud, L., Gréciano, S., Tuzin, N., Meyer, N., Trinh, A., Jesel, L., Ohlmann, P., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9092985 · Cited by 28
“In TTS, the troponin (Tn) rise in serum is low, contrasting with the dramatic extent of myocardial dysfunction [10].”
BackgroundReverse takotsubo cardiomyopathy: after an episode of serotonin syndrome.
Mehta, N. K., Aurigemma, G. P., Rafeq, Z., & Starobin, O. E. (2011) · Europe PMC (PubMed Central) · Cited by 28
“Lambda‐wave” ST ‐elevation is associated with severe prognosis in stress (takotsubo) cardiomyopathy
Tarantino, N. M., Santoro, F., Guastafierro, F., Martino, L. F. M. D., Scarcia, M., Ieva, R., Ruggiero, A., Cuculo, A., Mariano, E. G., Biase, M. D., et al. (2018) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12581 · Cited by 29
Postpartum Depression and Apical Ballooning Syndrome (Takotsubo Syndrome)
Yaqub, Y., Jenkins, L. A., NUGENT, K. M., & Chokesuwattanaskul, W. (2009) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/s1701-2163(16)34279-7 · Cited by 28
Takotsubo Syndrome: Clinical Manifestations, Etiology and Pathogenesis
Прокудина, Е. С., Kurbatov, B. K., Zavadovsky, K. V., Vrublevsky, A. V., Naryzhnaya, N. V., IuB, L., Маслов, Л. Н., & Oeltgen, P. R. (2020) · Current Cardiology Reviews · doi:10.2174/1573403x16666200129114330 · Cited by 27
“Troponin T peak in patients with AMI is 6- fold higher than in patients with stress cardiomyopathy [60].”
BackgroundSharkey, S. W., Lesser, J. R., Garberich, R., Pink, V. R., Maron, M. S., & Maron, B. J. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2012.04.060 · Cited by 27
Self-citationDiagnosis, Investigation and Management of Patients with Acute and Chronic Myocardial Injury
Taggart, C., Wereski, R., Mills, N. L., & Chapman, A. R. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112331 · Cited by 27
“These patients, however, quite often only display a modest rise in troponin level in comparison to the degree of left ventricular dysfunction and studies have suggested patients with high troponin levels at presentation are unlikely to have Takotsubo cardiomyopathy [38,39].”
Zorzi, A., Baritussio, A., ElMaghawry, M., Siciliano, M., Migliore, F., Marra, M. P., Iliceto, S., & Corrado, D. (2015) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872615585515 · Cited by 26
Zhong-qun, Z., Chong‐quan, W., Sclarovsky, S., Nikus, K. C., Chao-rong, H., & Shan, M. (2012) · Journal of Electrocardiology · doi:10.1016/j.jelectrocard.2012.11.013 · Cited by 25
Nowak, R., Fijalkowska, M., Gilis‐Malinowska, N., Jaguszewski, M. J., Gałąska, R., Rojek, A., Narkiewicz, K., Gruchała, M., & Fijałkowski, M. (2017) · Cardiology Journal · doi:10.5603/cj.a2017.0001 · Cited by 24
Takotsubo Myocardiopathy and Hyperthyroidism: A Case Report and Literature Review
Rueda, D. A., Aguirre, R., Contardo, D. M., Finocchietto, P. V., Hernandez, S. F., & di Fonzo, H. (2017) · American Journal of Case Reports · doi:10.12659/ajcr.905121 · Cited by 24
“In TM, the MRI may show an isolated mid-wall or subepicardial pattern of late gadolinium enhancement (LGE), whereas either subendocardial or transmural LGE is observed in AMI [11,12].”
ResultInfluentialFranco, E., Dias, A. M., Koshkelashvili, N., Pressman, G. S., Hebert, K. A., & Figueredo, V. M. (2016) · Annals of Noninvasive Electrocardiology · doi:10.1111/anec.12337 · Cited by 23
Stress-Induced Cardiomyopathy and Psychological Wellbeing 1 Year After an Acute Event
Compare, A., Grossi, E., Bigi, R., Proietti, R., Shonin, E., Orrego, P. S., & Poole, L. (2013) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-013-9380-1 · Cited by 22
Sharkey, S. W. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2012.12.006 · Cited by 21
Self-citationEndogenous stress response in Tako-Tsubo cardiomyopathy and acute myocardial infarction
Meissner, J., NEF, H. M., Darga, J., Kovács, M., Weber, M. W., Hamm, C. W., Möllmann, H., Twerenbold, R., Reiter, M., Heinisch, C., et al. (2011) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2011.02487.x · Cited by 21
Couch, L. S., Garrard, J., Henry, J. A., Kotronias, R. A., Alaour, B., Maria, G. L. D., Channon, K. M., BANNING, A. P., Lyon, A. R., Marber, M. S., et al. (2024) · Open Heart · doi:10.1136/openhrt-2024-002607 · Cited by 21
Yokoyama, H., Higuma, T., Endo, T., Nishizaki, F., Hanada, K., Yokota, T., Yamada, M., Okumura, K., & Tomita, H. (2017) · Journal of Cardiology · doi:10.1016/j.jjcc.2017.08.003 · Cited by 19
“reported that cTn elevations occurred in 95% of patients with takotsubo cardiomyopathy and those with AMI during hospitalization; however, the mean peak cTn level was significantly lower in patients with takotsubo cardiomyopathy [14].”
BackgroundSharma, A., Singh, J. P., & Heist, E. K. (2011) · Critical Pathways in Cardiology A Journal of Evidence-Based Medicine · doi:10.1097/hpc.0b013e31822f4d37 · Cited by 18
Takotsubo cardiomyopathy – An unexpected complication in spine surgery
Hammer, N., Kühne, C., Meixensberger, J., Hänsel, B., & Winkler, D. F. H. (2014) · International Journal of Surgery Case Reports · doi:10.1016/j.ijscr.2014.10.002 · Cited by 17
Two Unusual Cases of Takotsubo Cardiomyopathy Presenting With Sudden Cardiac Death
Mathew, B., & Villarreal, D. (2009) · The American Journal of the Medical Sciences · doi:10.1097/maj.0b013e3181956f49 · Cited by 16
Stress cardiomyopathy syndrome: A contemporary review
Kapoor, D., & Bybee, K. A. (2009) · Current Heart Failure Reports · doi:10.1007/s11897-009-0036-2 · Cited by 16
“All large cohort reports of SC have shown that most patients presenting with the syndrome are postmenopausal women [2,6,10,12, 15 ,18].”
BackgroundInfluentialCoronary vasospasm is an unlikely cause of Takotsubo syndrome, although we should keep an open mind
Madias, J. E. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.06.069 · Cited by 15
Electrocardiogram changes and wall motion abnormalities in the acute phase of Tako-Tsubo syndrome
Weihs, V., Szücs, D., Fellner, B., Eber, B., Weihs, W., Lambert, T., Metzler, B., Titscher, G., Hochmayer, B., Dechant, C., et al. (2015) · European Heart Journal Acute Cardiovascular Care · doi:10.1177/2048872615598630 · Cited by 14
Takotsubo cardiomyopathy associated with status epilepticus
Seow, S., Lee, Y. ‐., Teo, S.-G., Hong, E. C. T., & Lee, C. (2008) · European Journal of Neurology · doi:10.1111/j.1468-1331.2008.02125.x · Cited by 14
Lee, S., Lee, S. E., Rhee, T., Park, J. J., Cho, H., Lee, H., Choi, D., & Oh, B. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.02.071 · Cited by 13
Martin, C. S., Ionescu, L. N., Barbu, C. G., Sîrbu, A. M., Lambrescu, I. M., Lăcău, I. S., Dimulescu, D. R., & Fica, S. V. (2014) · BMC Endocrine Disorders · doi:10.1186/1472-6823-14-10 · Cited by 13
“This catecholamine hypotesis is also supported by the rat models, where Takostubo has been prevented with adrenergic blockade, by sampling of cardiac catecholamine levels in TCM [31] and by the reported cases in association with pheochromocytoma [32] and use of exogenous sympathomimetics.”
BackgroundVivo, R. P., Krim, S. R., & Hodgson, J. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0768-9 · Cited by 13
THROMBOLYSIS IN MYOCARDIAL INFARCTION FRAME COUNT IN TAKOTSUBO CARDIOMYOPATHY
Khalid, N. M., Iqbal, I., & Ikram, S. (2013) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(13)60051-0 · Cited by 12
Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives
Mauriello, A., Giudice, C. D., Vecchio, G. E. D., Correra, A., Maratea, A. C., Grieco, M., Amata, A., Quagliariello, V., Maurea, N., Proietti, R., et al. (2025) · Antioxidants · doi:10.3390/antiox14050522 · Cited by 13
“Several studies based on thrombolysis in myocardial infarction (TIMI) frame count, coronary flow reserve (CFR), and myocardial contrast echocardiography (MCE) showed impaired coronary flow in specific left ventricular segments, which contributes to myocardial dysfunction in TTS patients [56,60,61].”
NATIONAL EXPERIENCE WITH WEARABLE CARDIOVERTER-DEFIBRILLATOR USE IN TAKOTSUBO CARDIOMYOPATHY
Deeprasertkul, P., Opreanu, M., Bianco, N. R., & Thakur, R. K. (2013) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(13)60361-7 · Cited by 12
“Repolarization abnormalities predisposing to VA are often observed in TCM patients, including diffuse T-wave inversion and QT prolongation.(18) This pattern of electrocardiographic changes may also be seen in patients with hyperadrenergic states.”
BackgroundCoronary microvascular dysfunction in Takotsubo syndrome: cause or consequence.
Y‐Hassan, S. (2021) · PubMed Central · Cited by 12
Vriz, O., Minisini, R., Zito, C., Boccato, E., Fimiani, F., Pirisi, M., Facciolo, C., Limongelli, G., Bossone, E., & Calabrò, P. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.07.054 · Cited by 12
Implications of Using the Cabrera Sequence for Diagnosing Acute Coronary Syndrome
Kosuge, M., & Kimura, K. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0126 · Cited by 12
Broken Heart Syndrome, Neurogenic Stunned Myocardium and Stroke
Dande, A. S., & Pandit, A. S. (2013) · Current Treatment Options in Cardiovascular Medicine · doi:10.1007/s11936-013-0235-8 · Cited by 11
Matabuena‐Gomez‐Limon, J., Isaza-Arana, S., Robledo-Carmona, J., Alania-Torres, E., Torres-Llergo, J., Valle‐Racero, J. I., López-Pardo, F. J., Martínez‐Martínez, Á., Jiménez-Navarro, M. F., & Urbano-Moral, J. Á. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.11.256 · Cited by 11
Mechanisms of Takotsubo cardiomyopathy; role of microcirculatory dysfunction
Khalid, N. M. (2016) · International Cardiovascular Forum Journal · doi:10.17987/icfj.v5i0.237 · Cited by 10
Schimpf, R., Meinhardt, J., Borggrefe, M., & Haghi, D. (2013) · Herzschrittmachertherapie + Elektrophysiologie · doi:10.1007/s00399-013-0248-8 · Cited by 10
Takotsubo cardiomyopathy: etiology, diagnosis, and optimal management
Liang, J. J., & Wan, S. (2014) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s46021 · Cited by 10
“41 On cardiac angiography, the coronary arteries do not demonstrate coronary artery occlusions corresponding to the degree and areas of left ventricular dysfunction.”
Isogai, T., Yoshikawa, T., Yamaguchi, T., Arao, K., Ueda, T., Imori, Y., Maekawa, Y., Murakami, T., Yamamoto, T., Nagao, K., et al. (2018) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2018.07.042 · Cited by 10
Bayón, J., Santás‐Álvarez, M., Ocaranza‐Sánchez, R., & González‐Juanatey, C. (2019) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2017.08.014 · Cited by 9
Tsai, T. T., Nallamothu, B. K., Prasad, A., Saint, S. K., & Bates, E. (2009) · New England Journal of Medicine · doi:10.1056/nejmcps0903023 · Cited by 9
Naser, N., Buksa, M., Kušljugić, Z., Terzić, I., Sokolović, Š., & Hodžić, E. (2011) · Medical Archives · doi:10.5455/medarh.2011.65.287-290 · Cited by 9
“5% of all patients presenting with an initial clinically suspected acute coronary syndrome (ACS) (1, 9, 10, 11, 12, 12, 13, 14, 15, 16, 17, 18, 19, 20).”
BackgroundInfluentialParkkonen, O., Nieminen, M. T., Vesterinen, P., Tervahartiala, T. I., Perola, M., Salomaa, V. V., Jousilahti, P., Sorsa, T. A., Pussinen, P. J., & Sinisalo, J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173371 · Cited by 9
Sepsis İlişkili Miyokardiyal Depresyon ve Takotsubo Sendromu
Arslantaş, M. K., Altun, G. T., & Cinel, İ. (2015) · Türk yoğun bakım derneği dergisi/Türk yoğun bakım dergisi · doi:10.4274/tybdd.85547 · Cited by 8
Looi, J., Poppe, K., Lee, M., Gilmore, J., Webster, M. W. I., To, A. C. Y., & Kerr, A. (2020) · Open Heart · doi:10.1136/openhrt-2019-001197 · Cited by 8
Wilk, A., Król, W., Żarek-Starzewska, A., Ziemska‐Gorczyca, M., Tetera, W., Konopka, M. A., Binkiewicz‐Orluk, M., & Braksator, W. (2022) · Echocardiography · doi:10.1111/echo.15510 · Cited by 8
Parsa, S. A., Khaheshi, I., Memaryan, M., & Naderian, M. (2016) · Future Cardiology · doi:10.2217/fca-2016-0040 · Cited by 8
Pawlak, M., Roik, M. F., Kochanowski, J., Ścisło, P., Kowalik, R., Huczek, Z., Dąbrowska, K., & Opolski, G. (2012) · PubMed · Cited by 8
Psychiatric Symptoms, Personality Profile, and Takotsubo Syndrome: Clinical Considerations
Wittstein, I. S., Proietti, R., & Compare, A. (2012) · Springer eBooks · doi:10.1007/978-1-4419-5650-7_6 · Cited by 7
Chen, Y., Lai, H., Lee, W.-L., & Liu, T.-J. (2020) · International Heart Journal · doi:10.1536/ihj.20-118 · Cited by 7
Takotsubo cardiomyopathy: Completely simple but not so easy
Napp, L. C., Ghadri, J. R., Cammann, V. L., Bauersachs, J. K., & Templin, C. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.06.043 · Cited by 7
“1), a feature which is supposed to discriminate between ACS and TTCM with high specificity [9].”
BackgroundTakotsubo cardiomyopathy and microvascular dysfunction
Chhabra, L., & Sareen, P. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.05.161 · Cited by 7
“The mean TFC prolongation was however only modest in that study (5 and 7 counts in LAD and LCx arteries respectively), suggesting thatmicrovascular dysfunction plays only aminor role in the pathogenesis of TC [5].”
Result
Metadata
- Authors
- Sharkey, S. W., Lesser, J. R., Menon, M., Parpart, M., Maron, M. S., & Maron, B. J.
- Affiliations
- Minneapolis Heart Institute Foundation (US)
- Tufts Medical Center (US)
- Corresponding author
- Maron, Barry J.
- Venue
- The American Journal of Cardiology
- Publisher
- Elsevier BV
- Published
- 2008-06
- Volume
- 101
- Issue
- 12
- Pages
- 1723-1728
- ISSN
- 0002-9149 (ISSN-L)
- OpenAlex
- W1992921450
- Cited by
- 171
- References
- 24
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 5 · 2021: 3 · 2020: 8 · 2019: 5 · 2018: 4 · 2017: 11 · 2016: 16 · 2015: 20 · 2014: 19 · 2013: 17 · 2012: 13
- FWCI
- 8.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Takotsubo Cardiomyopathy and Associated Phenomena
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiac Imaging and Diagnostics
- Keywords
- takotsubo cardiomyopathy, ST-elevation myocardial infarction, electrocardiographic pattern, troponin T, TIMI frame count, T-wave inversion, differential diagnosis, acute coronary syndrome, left anterior descending artery occlusion, ejection fraction, women, emotional stress, physical stress, chest pain, coronary angiography
- MeSH terms
- Adult, Aged, Aged, 80 and over, Electrocardiography, Female, Follow-Up Studies, Humans, Middle Aged, Myocardial Infarction, Prognosis, Prospective Studies, Severity of Illness Index, Thrombolytic Therapy, Troponin T, Takotsubo Cardiomyopathy
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