Diets to prevent coronary heart disease 1957–2013: what have we learned
Open accessAbstract
Our understanding of the potential cardioprotective properties of nutrition is relatively recent, with most relevant studies completed in the last several decades. During that time, there has been an evolution in the focus of nutritional intervention. Early trials emphasized reduction of dietary fat with the goal of preventing heart disease by reducing serum cholesterol. Results from trials focused exclusively on dietary fat reduction were disappointing, prompting subsequent studies incorporating a whole diet approach with a nuanced recommendation for fat intake. The Mediterranean-style diet, with a focus on vegetables, fruit, fish, whole grains, and olive oil, has proven to reduce cardiovascular events to a degree greater than low-fat diets and equal to or greater than the benefit observed in statin trials.
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Strong evidence shows dietary factors may influence atherogenesis directly or through effects on traditional risk factors such as plasma lipids, blood pressure or glucose.
“There is strong evidence showing that dietary factors may influence atherogenesis directly or through effects on traditional risk factors such as plasma lipids, blood pressure or glucose levels.”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [132]
Some dietary interventions in randomized controlled trials resulted in significant cardiovascular disease prevention, whereas others did not.
“Some interventions resulted in significant CVD prevention, whereas others did not.”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [132]
Some dietary interventions resulted in significant cardiovascular disease prevention, whereas others did not.
“Some interventions resulted in significant CVD prevention, whereas others did not.”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [132]
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References 44 · Cited by 94
Research works printed but not linked: 3
- Ignatowski AI. Influence of animal food on the organism of rabbits. S Peterb Izv Imp Voyenno-med Akad. 1908;16:154-176.
- Groen J, Tjiong BK, Kamminga CE, et al. Influence of nutrition, in- dividuality, and some other factors, including various forms of stress, on serum cholesterol. Voeding. 1952;13:556-587.
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- Authors
- Dalen, J. E., & Devries, S.
- Affiliations
- University of Arizona (US)
- Northwestern University (US)
- Corresponding author
- Dalen, James E.
- ORCID
- Devries, Stephen
- Venue
- The American Journal of Medicine
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 127
- Issue
- 5
- Pages
- 364-369
- ISSN
- 0002-9343 (ISSN-L)
- OpenAlex
- W2076716913
- Cited by
- 94
- References
- 44
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 7 · 2020: 3 · 2019: 5 · 2018: 10 · 2017: 11 · 2016: 18 · 2015: 10 · 2014: 8 · 2013: 1
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The American Journal of Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- coronary heart disease prevention, dietary fat reduction, serum cholesterol, Mediterranean diet, dietary intervention, cardiovascular events, olive oil, statins, dietary recommendations
- MeSH terms
- Olive Oil, American Heart Association, Animals, Cholesterol, Coronary Artery Disease, Coronary Disease, Dietary Fats, Dietary Fats, Unsaturated, Feeding Behavior, Fishes, Fruit, Humans, Myocardial Infarction, Plant Oils, Primary Prevention, Risk Factors, United States, Vegetables, Randomized Controlled Trials as Topic, Treatment Outcome, Treatment Failure, Diet, Fat-Restricted, Diet, Mediterranean, Risk Reduction Behavior, Atherosclerosis, Secondary Prevention
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