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Cited by 34Pregnancy and Medication ImpactCardiovascular Issues in PregnancyAsthma and respiratory diseases

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Allergy Medications During Pregnancy

Gonzalez-Estrada, Alexei, Geraci, Stephen A.·2016·The American Journal of the Medical Sciences
DOI 10.1016/j.amjms.2016.05.030
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Abstract

Allergic diseases are common in women of childbearing age. Both asthma and atopic conditions may worsen, improve or remain the same during pregnancy. Primary care physicians commonly encounter women receiving multiple medications for pre-existing atopic conditions, who then become pregnant and require medication changes to avoid potential fetal injury or congenital malformations. Each medication should be evaluated; intranasal and inhaled steroids are relatively safe to continue during pregnancy (budesonide is the drug of choice), second-generation antihistamines of choice are cetirizine and loratadine, leukotriene receptor antagonists are safe, sparing use of oral decongestants during the first trimester and omalizumab may be used for both uncontrolled asthma and for antihistamine-resistant urticaria. Medications to avoid during pregnancy include intranasal antihistamines, first-generation antihistamines, mycophenolate mofetil, methotrexate, cyclosporine, azathioprine and zilueton. Common allergic diseases may develop de novo during pregnancy, such as anaphylaxis.

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Research works printed but not linked: 45

  1. Incaudo, 2006, The diagnosis and treatment of allergic rhinitis during pregnancy and lactation, Immunol Allergy Clin North Am, 1, 137, 10.1016/j.iac.2005.10.005 · DOI
  2. Kwon, 2003, Asthma prevalence among pregnant and childbearing-aged women in the United States: estimates from national health surveys, Ann Epidemiol, 13, 317, 10.1016/S1047-2797(03)00008-5 · DOI
  3. Lieberman, 2006, Epidemiology of anaphylaxis: findings of the American College of Allergy, Asthma and Immunology Epidemiology of Anaphylaxis Working Group, Ann Allergy Asthma Immunol, 97, 596, 10.1016/S1081-1206(10)61086-1 · DOI
  4. Bernstein, 2014, The diagnosis of acute and chronic urticaria: 2014 update, J Allergy Clin Immunol, 133, 1270, 10.1016/j.jaci.2014.02.036 · DOI
  5. Kircher, 2002, Variables affecting asthma course during pregnancy, Ann Allergy Asthma Immunol, 89, 463, 10.1016/S1081-1206(10)62082-0 · DOI
  6. Roth, 1964, The natural history of atopic dermatitis. A 20-year follow-up study, Arch Dermatol, 89, 209, 10.1001/archderm.1964.01590260047008 · DOI
  7. Wallace, 2008, The diagnosis and management of rhinitis: an update practice parameter, J Allergy Clin Immunol, 122, 1237
  8. Adusumalli, 1992, Pharmacokinetics of azelastine and its active metabolite, demethylazelastine, in guinea pigs, Drug Metab Dispos, 20, 530
  9. Bernstein, 2009, Double-Blind, placebo-controlled trial of reformulated azelastine nasal spray in patients with seasonal allergic rhinitis, Am J Rhinol Allergy, 23, 512, 10.2500/ajra.2009.23.3396 · DOI
  10. Blaiss, 2010, Allergic rhinitis: direct and indirect costs, Allergy Asthma Proc, 31, 375, 10.2500/aap.2010.31.3329 · DOI · Paper page
  11. Ratner, 2008, Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis, Ann Allergy Asthma Immunol, 100, 74, 10.1016/S1081-1206(10)60408-5 · DOI
  12. Gilbert, 2005, Fetal safety of drugs used in the treatment of allergic rhinitis: a critical review, Drug Saf, 28, 707, 10.2165/00002018-200528080-00005 · DOI
  13. Einarson, 1997, Prospective controlled study of hydroxyzine and cetirizine in pregnancy, Ann Allergy Asthma Immunol, 78, 183, 10.1016/S1081-1206(10)63385-6 · DOI
  14. Kallen, 2002, Use of antihistamine drugs in early pregnancy and delivery outcome, J Matern Fetal Neonatal Med, 11, 146, 10.1080/jmf.11.3.146.152 · DOI
  15. Moretti, 2003, Fetal safety of loratadine use in the first trimester of pregnancy: a multicenter study, J Allergy Clin Immunol, 111, 479, 10.1067/mai.2003.130 · DOI
  16. Diav-Citrin, 2003, Pregnancy outcome after gestational exposure to loratadine or antihistamines: a prospective controlled cohort study, J Allergy Clin Immunol, 111, 1239, 10.1067/mai.2003.1499 · DOI
  17. 2007, Expert Panel Report 3 (EPR-3): guidelines for the diagnosis and management of Asthma-Summary Report 2007, J Allergy Clin Immunol, 120, S94
  18. Zuberbier, 2014, The EAACI/GA(2) LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update, Allergy, 69, 868, 10.1111/all.12313 · DOI
  19. Einarson, 2000, The antiemetic effect of cetirizine during pregnancy, Ann Pharmacother, 34, 1486, 10.1345/aph.10160 · DOI
  20. Bakhireva, 2007, Effect of maternal asthma and gestational asthma therapy on fetal growth, J Asthma, 44, 71, 10.1080/02770900601180313 · DOI
  21. Koren, 2010, Safety of using montelukast during pregnancy, Can Fam Physician, 56, 881
  22. Lekas, 1992, Rhinitis during pregnancy and rhinitis medicamentosa, Otolaryngol Head Neck Surg, 107, 845, 10.1177/019459989210700606.2 · DOI
  23. Toll, 2006, Phenylpropanolamine׳s decongestive effect on the nasalmucosa of pregnant women with nasal stuffiness, Rhinology, 44, 274
  24. Gluck, 1976, The effects of pregnancy on asthma: a prospective study, Ann Allergy, 37, 164
  25. 2005, NAEPP expert panel report. Managing asthma during pregnancy: recommendation for pharmacologic treatment-2004 update, J Allergy Clin Immunol, 115, 34, 10.1016/j.jaci.2004.10.023 · DOI
  26. Bain, 2014, Interventions for managing asthma in pregnancy, Cochrane Database Syst Rev, 21, 10
  27. Murphy, 2013, The risk of congenital malformations, perinatal mortality and neonatal hospitalization among pregnant women with asthma: a systematic review and meta-analysis, BJOG, 120, 812, 10.1111/1471-0528.12224 · DOI
  28. Cossette, 2014, Relative perinatal safety of salmeterol vs formoterol and fluticasone vs budesonide use during pregnancy, Ann Allergy Asthma Immunol, 112, 459, 10.1016/j.anai.2014.02.010 · DOI
  29. Nelson, 2006, The Salmeterol Multicenter Asthma Research Trial: a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol, Chest, 129, 15, 10.1378/chest.129.1.15 · DOI
  30. Gur, 2004, Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study, Reprod Toxicol, 18, 93, 10.1016/j.reprotox.2003.10.007 · DOI
  31. Park-Wyllie, 2000, Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies, Teratology, 62, 385, 10.1002/1096-9926(200012)62:6<385::AID-TERA5>3.0.CO;2-Z · DOI
  32. Stenius-Aarniala, 1988, Asthma and pregnancy: a prospective study of 198 pregnancies, Thorax, 43, 12, 10.1136/thx.43.1.12 · DOI
  33. Hviid, 2011, Corticosteroid use during pregnancy and risk of orofacial clefts, CMAJ, 183, 796, 10.1503/cmaj.101063 · DOI
  34. Chi, 2011, Evidence-based (S3) guideline on topical corticosteroids in pregnancy, Br J Dermatol, 165, 943, 10.1111/j.1365-2133.2011.10513.x · DOI
  35. Namazy, 2015, The Xolair Pregnancy Registry (EXPECT): the safety of omalizumab use during pregnancy, J Allergy Clin Immunol, 135, 407, 10.1016/j.jaci.2014.08.025 · DOI
  36. Vieira Dos Santos, 2014, Effects of omalizumab in a patient with three types of chronic urticaria, Br J Dermatol, 170, 469, 10.1111/bjd.12628 · DOI
  37. Ghazanfar, 2015, Successful and safe treatment of chronic spontaneous urticaria with omalizumab in a woman during two consecutive pregnancies, Case Rep Med, 2015, 368053, 10.1155/2015/368053 · DOI
  38. Pitsios, 2015, Clinical contraindications to allergen immunotherapy: an EAACI position paper, Allergy, 70, 897, 10.1111/all.12638 · DOI
  39. Gani, 2003, Rhinitis in pregnancy, Eur Ann Allergy Clin Immunol, 35, 306
  40. Turnbull, 1996, Managing pregnancy-related nocturnal nasal congestion. The external nasal dilator, J Reprod Med, 41, 897
  41. Eccles, 2000, Nasal airflow in health and disease, Acta Otolaryngol, 120, 580, 10.1080/000164800750000388 · DOI
  42. Mulla, 2010, Anaphylaxis in the obstetric patient: analysis of a statewide hospital discharge database, Ann Allergy Asthma Immunol, 104, 55, 10.1016/j.anai.2009.11.005 · DOI
  43. Macy, 2006, Penicillin skin testing women with a history of penicillin allergy and group B streptococcus colonization, Ann Allergy Asthma Immunol, 97, 164, 10.1016/S1081-1206(10)60007-5 · DOI
  44. Venter, 2006, Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life, J Allergy clin Immunol, 117, 1118, 10.1016/j.jaci.2005.12.1352 · DOI
  45. Fonacier, 2015, Contact dermatitis: a practice parameter-update 2015, J Allergy Clin Immunol Pract, 3, S1, 10.1016/j.jaip.2015.02.009 · DOI

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Metadata

Authors
Gonzalez-Estrada, A., & Geraci, S. A.
Affiliations
East Tennessee State University (US)
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2016-09
Volume
352
Issue
3
Pages
326-331
ISSN
0002-9629 (ISSN-L)
DOI
10.1016/j.amjms.2016.05.030
OpenAlex
W2471531131
Cited by
34
References
5
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 4 · 2022: 9 · 2021: 4 · 2020: 5 · 2019: 5 · 2018: 1 · 2017: 3
FWCI
0.44
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
  • Digital Commons - East Tennessee State University (East Tennessee State University) (submittedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Pregnancy and Medication Impact
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Issues in Pregnancy
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords
asthma in pregnancy, atopic diseases, intranasal corticosteroids, budesonide, second-generation antihistamines, cetirizine, loratadine, leukotriene receptor antagonists, oral decongestants, omalizumab, drug safety in pregnancy, congenital malformations, mycophenolate mofetil, methotrexate, cyclosporine, azathioprine, zileuton, anaphylaxis
MeSH terms
Asthma, Female, Histamine Antagonists, Humans, Hypersensitivity, Pregnancy, Pregnancy Complications, Nasal Decongestants, Anti-Allergic Agents

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