Antibacterial activity of Lactobacillus spp. isolated from the feces of healthy infants against enteropathogenic bacteria
Abstract
Lactobacilli are normal microflora of the gastrointestinal (GI) tract and are a heterogeneous group of lactic acid bacteria (LAB). Lactobacillus strains with Probiotic activity may have health Benefits for human. This study investigates the probiotic potential of Lactobacillus strains obtained from the feces of healthy infants and also explores antibacterial activity of Lactobacillus strains with probiotic potential against enteropathogenic bacteria. Fecal samples were collected from 95 healthy infants younger than 18 months. Two hundred and ninety Lactobacillus strains were isolated and assessed for probiotic potential properties including ability to survive in gastrointestinal conditions (pH 2.0, 0.3% oxgall), adherence to HT-29 cells and antibiotic resistance. Six strains including Lactobacillus fermentum (4 strains), Lactobacillus paracasei and Lactobacillus plantarum showed good probiotic potential and inhibited the growth of enteropathogenic bacteria including ETEC H10407, Shigella flexneri ATCC 12022, Shigella sonnei ATCC 9290, Salmonella enteritidis H7 and Yersinia enterocolitica ATCC 23715. These Lactobacillus strains with probiotic potential may be useful for prevention or treatment of diarrhea, but further in vitro and in vivo studies on these strains are still required.
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It is essential for bacteria to possess defense systems to withstand harsh conditions like low pH, digestive enzymes, and bile.
“Therefore, it is essential for bacteria to possess defense systems to withstand the typical harsh conditions encountered in this environment, like low pH, different digestive enzymes, and bile [44,45].”
From The Biological Role of the S-Layer Produced by Lactobacillus helveticus 34.9 in Cell Protection and Its Probiotic Properties (2024) · cites this paper as [44]
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References 36 · Cited by 77
- Authors
- Davoodabadi, A., Soltan Dallal, M. M., Rahimi Foroushani, A., Douraghi, M., Sharifi Yazdi, M. K., & Amin Harati, F.
- Affiliations
- Tehran University of Medical Sciences (IR)
- ORCID
- Douraghi, Masoumeh
- Venue
- Anaerobe
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 34
- Pages
- 53-58
- ISSN
- 1075-9964 (ISSN-L)
- OpenAlex
- W2025925608
- Cited by
- 77
- References
- 36
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 3 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 14 · 2019: 8 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2
- FWCI
- 6.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Anaerobe (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Vice-Chancellor for Research grant (21491)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Immunology and Microbiology › Microbiology › Reproductive tract infections research
- Keywords
- Lactobacillus, probiotic potential, antibacterial activity, infant feces, enteropathogenic bacteria, Lactobacillus fermentum, Lactobacillus paracasei, Lactobacillus plantarum, enterotoxigenic Escherichia coli, Shigella, Salmonella Enteritidis, Yersinia enterocolitica, gastrointestinal survival, antibiotic resistance, diarrhea prevention
- MeSH terms
- Antibiosis, Bacterial Adhesion, Epithelial Cells, Feces, Humans, Hydrogen-Ion Concentration, Infant, Lactobacillus, Salmonella enteritidis, Shigella, Yersinia enterocolitica, Drug Resistance, Bacterial, Microbial Viability, Healthy Volunteers
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