Intranasal mometasone furoate therapy for allergic rhinitis symptoms and rhinitis-disturbed sleep
Abstract
Background Allergic rhinitis (AR) and related nasal congestion cause rhinitis-disturbed sleep (RDS). Intranasal corticosteroids reduce nasal congestion and improve sleep quality in AR but have not been extensively studied in RDS. Objective To evaluate the efficacy of mometasone furoate nasal spray (NS) on nasal symptoms, nasal patency, sleep variables, quality of life, and daytime functioning in perennial AR (PAR) and concomitant RDS. Methods In this double-blind 4-week study, 30 adults with PAR and moderate RDS were randomized 2:1 to receive mometasone furoate NS, 200 microg, or placebo each morning. The primary end point was the apnea-hypopnea index. Secondary outcome measures included changes in total nasal symptom score (TNSS), nighttime symptom score, daytime peak nasal inspiratory flow, nighttime flow limitation index, Rhinoconjunctivitis Quality of Life Questionnaire-Standardized (RQLQ-S) score, Epworth Sleepiness Scale score, and Work Productivity and Activities Impairment-Allergy Specific (WPAI-AS) questionnaire score. Analysis of covariance was used for all efficacy end points. Results The apnea-hypopnea index at study end was not statistically significantly different between groups. However, mometasone furoate NS therapy significantly improved morning (P = .04) and evening (P = .01) TNSSs, morning (P = .049) and evening (P = .03) nasal obstruction/blockage/congestion, daily peak nasal inspiratory flow (P = .03), flow limitation index (P = .02), Epworth Sleepiness S…
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Effective treatment of NO can reduce the daytime sleepiness resulting from sleep disturbances in allergic rhinitis.
“On the other hand, effective treatment of NO can reduce the daytime sleepiness resulting from sleep disturbances in AR [100].”
From Position Paper on Nasal Obstruction: Evaluation and Treatment (2018) · cites this paper as [100]
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- Authors
- Meltzer, E. O., Munafo, D. A., Chung, W., Gopalan, G., & Varghese, S. T.
- Affiliations
- Allergy and Asthma Medical Group and Research Center (US)
- University of California San Diego (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- Corresponding author
- Meltzer, Eli O.
- ORCID
- Varghese, Santosh T.
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 105
- Issue
- 1
- Pages
- 65-74
- ISSN
- 1081-1206 (ISSN-L)
- OpenAlex
- W2080151318
- Cited by
- 55
- References
- 3
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 2 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 6 · 2013: 4 · 2012: 8
- FWCI
- 2.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Allergy Asthma & Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Allergic Rhinitis and Sensitization
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Surgery › Nasal Surgery and Airway Studies
- Keywords
- allergic rhinitis, mometasone furoate, intranasal corticosteroids, nasal congestion, nasal obstruction, sleep apnea, daytime sleepiness, quality of life, labor productivity, perennial allergic rhinitis
- MeSH terms
- Mometasone Furoate, Activities of Daily Living, Administration, Intranasal, Adolescent, Adult, Female, Humans, Male, Middle Aged, Pregnadienediols, Quality of Life, Rhinitis, Allergic, Perennial, Sleep Apnea Syndromes, Nasal Obstruction, Anti-Allergic Agents
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