The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
The prevalence and persistence of atopic dermatitis in urban United States children
Abstract
Background Previous studies found that childhood atopic dermatitis (AD) and asthma are associated with residence in urban areas. However, little is known about the prevalence and determinants of AD in US urban populations and its impact on quality-of-life (QOL) and asthma.Objective To determine AD prevalence and persistence, sociodemographic predictors thereof, and association with QOL and atopic comorbidities in US urban children.Methods We analyzed data from The Fragile Families and Child Wellbeing Study, a prospective cohort study of 4898 women and their children born in 20 large US cities between 1998 and 2000. AD prevalence was determined at ages 5, 9, and 15 years, and stratified by sex, race/ethnicity, and household poverty income level.Results The prevalences (95% confidence interval [CI]) of childhood AD were 15.0% (11.0%-18.9%), 15.1% (11.5%-18.7%), and 14.5% (10.4%%-18.5%) at ages 5, 9, and 15 years, respectively. Female sex (multivariable repeated measures logistic regression; adjusted odds-ratio [95% CI]: 1.56 [1.02-2.37]) and black race (1.80 [1.07-3.01]) were associated with persistent AD across all 3 ages. Children with AD at ages 5 and 15 (2.63 [1.42-4.86]), 5, 8 and 15 (1.47 [1.02-2.12]) and 9 and 15 years (1.61 [1.00-2.60]) had higher odds of poor/fair/good overall health. Children with AD at ages 5 and 9 years had the highest odds of ever having asthma (adjusted odds ratio [95% confidence interval]: 6.05 [5.88-6.22]), followed by children with AD at ages 5, 9, and 15 years (3.17 [3.07%-3.27]).Conclusion Atopic dermatitis prevalence and persistence were highest in US urban children who were female or black. Urban children with persistent AD were more likely to have poor QOL and asthma.
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“It is noteworthy that the prevalence of AD in South Korea is nearly 30% compared with less than 20% in the United States (67, 68).”
From Particulate matter causes skin barrier dysfunction. (2021) · cites this paper as [68]
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Fragile Families: sample and design
Reichman, N. E., Teitler, J. O., Garfinkel, I., & McLanahan, S. (2001) · Children and Youth Services Review · doi:10.1016/s0190-7409(01)00141-4 · Cited by 1,616
Eczema Prevalence in the United States: Data from the 2003 National Survey of Children's Health
Shaw, T., Currie, G. P., Koudelka, C. W., & Simpson, E. L. (2010) · Journal of Investigative Dermatology · doi:10.1038/jid.2010.251 · Cited by 721
Patient burden and quality of life in atopic dermatitis in US adults
Silverberg, J. I., Gelfand, J. M., Margolis, D. J., Boguniewicz, M., Fonacier, L. S., Grayson, M. H., Simpson, E. L., Ong, P. Y., & Fuxench, Z. C. C. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.07.006 · Cited by 665
Self-citationThe Burden of Pediatric Asthma
Ferrante, G., & Grutta, S. L. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00186 · Cited by 485
Environmental risk factors and their role in the management of atopic dermatitis
Kantor, R. W., & Silverberg, J. I. (2016) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2016.1212660 · Cited by 387
Self-citationSilverberg, J. I., Garg, N. K., Paller, A. S., Fishbein, A. B., & Zee, P. C. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.325 · Cited by 346
Self-citationSilverberg, J. I., & Simpson, E. L. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12095 · Cited by 310
Self-citationPersistence of atopic dermatitis (AD): A systematic review and meta-analysis
Kim, J. P., Chao, L. X., Simpson, E. L., & Silverberg, J. I. (2016) · Journal of the American Academy of Dermatology · doi:10.1016/j.jaad.2016.05.028 · Cited by 275
Self-citationMortz, C. G., Andersen, K. E., Dellgren, C., Barington, T., & Bindslev‐Jensen, C. (2015) · Allergy · doi:10.1111/all.12619 · Cited by 267
Burden of skin pain in atopic dermatitis
Vakharia, P. P., Chopra, R., Sacotte, R. M., Patel, K. R., Singam, V., Patel, N., Immaneni, S., White, T., Kantor, R. W., Hsu, D. Y., et al. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.09.076 · Cited by 222
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Atopic Dermatitis and Emotional and Behavioral Outcomes in Urban U.S. Children: A Birth Cohort Study
Schneiderman, M., & Derrick, K. M. (2025) · Dermatitis · doi:10.1177/17103568251368268
Chen, Y., Wang, S.-H., Tai, C., & Chi, C. (2025) · JDDG Journal der Deutschen Dermatologischen Gesellschaft · doi:10.1111/ddg.15823_g
Rams, A. R., Baldasaro, J., Bunod, L., Delbecque, L., Strzok, S., Meunier, J., Elmaraghy, H., Sun, L., & Pierce, E. J. (2024) · Figshare · doi:10.6084/m9.figshare.26353316
Pápulas en los codos y las rodillas como hallazgo clínico en la dermatitis atópica
López, J. V. (2026) · Piel · doi:10.1016/j.piel.2025.07.006
Narla, S., & Silverberg, J. I. (2026) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2026.04.010
Self-citationSingh, A. M. (2026) · ImmPort · doi:10.21430/m3kh6o4auw
Metadata
- Authors
- McKenzie, C., & Silverberg, J. I.
- Affiliations
- Northwestern University (US)
- Corresponding author
- Silverberg, Jonathan I.
- Venue
- Annals of Allergy, Asthma & Immunology
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 123
- Issue
- 2
- Pages
- 173-178.e1
- ISSN
- 1081-1206 (ISSN-L)
- OpenAlex
- W2946322933
- Cited by
- 105
- References
- 25
- Citations by year
- 2026: 2 · 2025: 10 · 2024: 22 · 2023: 10 · 2022: 21 · 2021: 24 · 2020: 13 · 2019: 3
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Allergy Asthma & Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Dermatology Foundation
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Keywords
- atopic dermatitis, pediatric atopic dermatitis, prevalence, disease persistence, urban children, quality of life, asthma comorbidity, sociodemographic predictors, sex differences, racial disparities, Fragile Families and Child Wellbeing Study, household poverty, urban-rural differences, childhood asthma risk factors
- MeSH terms
- Adolescent, Asthma, Black or African American, Child, Child, Preschool, Dermatitis, Atopic, Female, Health Status, Hispanic or Latino, Humans, Male, Prospective Studies, Quality of Life, Surveys and Questionnaires, United States, Urban Population, White People
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