Predictive value of neutrophil to lymphocyte ratio in first-time and recurrent idiopathic sudden sensorineural hearing loss
Abstract
Objective To determine if the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) in patients with recurrent idiopathic sudden sensorineural hearing loss (ISSNHL) differ from those in healthy people and non-recurrent ISSNHL patients. Methods A retrospective review of 16 patients with recurrent ISSNHL was performed with strict exclusion criteria. Independent variables were NLR and PLR, which yielded four groups (control, non-recurrent, recurrent-first attack, and recurrent-second attack groups). Results Compared with the control group, non-recurrent and recurrent attack groups showed significantly higher NLR values (p Conclusion Evidence of increased NLR and PLR is shown in recurrent ISSNHL and non-recurrent ISSNHL, and these increased levels are shown in the second attack of recurrent ISSNHL. Clinicians are advised to monitor the NLR and PLR at the clinic to predict recurrent ISSNHL even after hearing is restored.
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Seo et al. reported increased neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with recurrent SSNHL compared to controls.
“Seo et al. reported increased neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in patients with recurrent SSNHL compared to controls. 9”
From Recurrent sudden sensorineural hearing loss—A literature review (2022) · cites this paper as [9]
Four studies reported the improvement rate in patients with their first episode of SSNHL to be 58%-79%.
“Four studies 6,8 -10 reported the improvement rate in patients with their first episode of SSNHL to be 58% -79%.”
From Recurrent sudden sensorineural hearing loss—A literature review (2022) · cites this paper as [9]
The improvement rate of the recurrent SSNHL episode ranged from 21% to 86% across five studies.
“As for the improvement rate of the recurrent SSNHL episode, five studies, 8,9,11 -13 from 21% to 86%.”
From Recurrent sudden sensorineural hearing loss—A literature review (2022) · cites this paper as [9]
Both NLR and PLR were found to be higher in patients experiencing both the first and recurrent episodes of ISSNHL than in a normal control group.
“Both the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were found to be higher in patients experiencing both the first and recurrent episodes of ISSNHL than in a normal control group [9].”
From Prognostic Factors Associated with Recovery from Recurrent Idiopathic Sudden Sensorineural Hearing Loss: Retrospective Analysis and Systematic Review (2022) · cites this paper as [9]
Cited by
Sorted by citations
Jeon, S. Y., Kang, D. W., Kim, S. H., Byun, J. Y., & Yeo, S. G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051453 · Cited by 9 · see citing works
Recurrent sudden sensorineural hearing loss—A literature review
Zhang, B., Wang, Y., & Chan, K. (2022) · Laryngoscope Investigative Otolaryngology · doi:10.1002/lio2.828 · Cited by 9 · see citing works
- Authors
- Seo, Y. J., Park, Y. A., Bong, J. P., Park, D.-J., & Park, S. Y.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Park, Sang Yoo
- Venue
- Auris Nasus Larynx
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 42
- Issue
- 6
- Pages
- 438-442
- ISSN
- 0385-8146 (ISSN-L)
- OpenAlex
- W1592623817
- Cited by
- 32
- References
- 0
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 6 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 1
- FWCI
- 1.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Auris Nasus Larynx (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Keywords
- neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, idiopathic sudden sensorineural hearing loss, inflammatory markers, risk prediction, hearing restoration
- MeSH terms
- Adult, Blood Platelets, Hearing Loss, Sudden, Female, Hearing Loss, Sensorineural, Humans, Lymphocytes, Male, Middle Aged, Neutrophils, Platelet Count, Predictive Value of Tests, Recurrence, Retrospective Studies, Cohort Studies, Odds Ratio, Lymphocyte Count
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