Short Sleep Duration is Associated with the Development of Impaired Fasting Glucose: The Western New York Health Study
Open accessAbstract
Purpose To examine whether sleep duration was associated with incident-impaired fasting glucose (IFG) over 6 years of follow-up in the Western New York Health Study.Methods Participants (N = 1,455, 68% response rate) who were free of type 2 diabetes and known cardiovascular disease at baseline (1996-2001) were reexamined in the period 2003-2004. A nested case-control study was conducted. Cases had fasting plasma glucose (FPG) less than 100 mg/dL at baseline and 100 to 125 mg/dL at follow-up: controls (n = 272) had FPG less than 100 mg/dL at both exams. Cases (n = 91) were individually matched to three controls (n = 272) on sex, race, and year of study enrollment. Average sleep duration was categorized as short (<6 hours), mid-range (6 to 8 hours), and long (>8 hours).Results In multivariate conditional logistic regression after adjustment for several diabetes risk factors, the odds ratio (OR) of IFG among short sleepers was 3.0 (95% confidence limit [CL]: 1.05, 8.59) compared to mid-range sleepers. There was no association between long sleep and IFG: OR 1.6 (95% CL: 0.45, 5.42). Adjustment for insulin resistance attenuated the association only among short sleepers: OR 2.5 (95% CL: 0.83, 7.46).Conclusions Short sleep duration was associated with an elevated risk of IFG. Insulin resistance appears to mediate this association.
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Prospective epidemiologic studies indicate that insufficient sleep is associated with a higher risk of insulin resistance, obesity, and type 2 diabetes.
“Insufficient sleep increases the risk for insulin resistance, type 2 diabetes, and obesity, suggesting that sleep restriction may impair peripheral metabolic pathways.”
From Impaired Insulin Signaling in Human Adipocytes After Experimental Sleep Restriction: A Randomized, Crossover Study (2012) · cites this paper as [10]
The Introduction (page unavailable) reports prospective evidence linking short sleep with incident type 2 diabetes and observational evidence linking inadequate sleep with obesity. The Results and Discussion (page unavailable) link short sleep to incident impaired fasting glucose and discuss insulin resistance as a possible mediator, but do not establish a higher risk of developing insulin resistance. The paper does not present prospective evidence for all three outcomes. (LLM, conf=0.88)
Experimental — accuracy not yet measuredThere is strong evidence that short sleep duration is associated with greater insulin resistance and disrupted glucose metabolism.
“Taken together, there is strong evidence that short sleep duration is associated with greater insulin resistance and disrupted glucose metabolism.”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [11]
Short sleep duration is associated with impaired insulin sensitivity and glucose metabolism.
“Data from both small and large cohort studies suggest that short sleep duration is associated with impaired insulin sensitivity and glucose metabolism (Table 1).”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [11]
Individuals who sleep fewer than 6 h per night are 3 times more likely to have impaired fasting glucose compared with those who sleep 6-8 h per night.
“Rafalson et al. reported that those who sleep fewer than 6 h per night are 3 times more likely to have impaired fasting glucose compared with those who sleep 6-8 h per night.11”
From The effects of sleep disruption on metabolism, hunger, and satiety, and the influence of psychosocial stress and exercise: A narrative review (2024) · cites this paper as [11]
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References 30 · Cited by 118
- Authors
- Rafalson, L., Donahue, R. P., Stranges, S., Lamonte, M. J., Dmochowski, J., Dorn, J., & Trevisan, M.
- Affiliations
- University at Buffalo, State University of New York (US)
- University of Warwick (GB)
- University of North Carolina at Charlotte (US)
- Corresponding author
- Rafalson, Lisa
- Venue
- Annals of Epidemiology
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 20
- Issue
- 12
- Pages
- 883-889
- ISSN
- 1047-2797 (ISSN-L)
- PMC
- PMC2962429
- OpenAlex
- W2031663866
- Cited by
- 118
- References
- 30
- Citations by year
- 2026: 4 · 2024: 6 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 8 · 2016: 12 · 2015: 11 · 2014: 9 · 2013: 10 · 2012: 11
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK060587, R01 DK60587)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Keywords
- sleep duration, impaired fasting glucose, prediabetes, type 2 diabetes risk, insulin resistance, long sleep, short sleep duration
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Type 2, Fasting, Female, Follow-Up Studies, Glucose Tolerance Test, Humans, Insulin Resistance, Male, Middle Aged, New York, Surveys and Questionnaires, Risk Factors, Sleep Deprivation, Logistic Models, Case-Control Studies
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